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A Standard for Quantifying Yohimbe in Dietary Supplements

SRM 3383 Yohimbe-Containing Solid Oral Dosage Form

SRM 3383
Credit: Lane Sanders

SRM 3383 Yohimbe-Containing Solid Oral Dosage Form is part of a continuing collaboration with NIH-Office of Dietary Supplements to develop dietary supplement reference materials.  Yohimbe bark and its extract are derived from a tree native to tropical West Africa.  These materials are popular herbal supplements used as a general tonic, performance enhancer, and as an aphrodisiac.  In 2017, the American Botanical Council reported that the mainstream market of herbal supplements in the United States in 2016 was 7.45 billion dollars. Yohimbe represents almost 21 million dollars of these sales and ranked 13th in their listing of the top 40 bestselling herbs/supplements in the US.  Yohimbine is the major and most active alkaloid present in yohimbe bark and yohimbine HCl is available in the United States as a prescription drug.  SRM 3383 was produced from multiple commercial dietary supplements containing yohimbe to replicate typical analytical challenges associated with the measurement of yohimbine in a finished product sample matrix. 

SRM 3383 is a finely ground powdered prepared from a mixture of four commercially available yohimbine containing finished products.  The material was prepared at NIST and packaged by High Purity Standards, an experienced contract manufacturer. 

A unit of SRM 3383 consists of 5 packets, each containing approximately 1.1 g of material.

Learn More:
Wilson WB, Coskun SH, Mulloor J, Nelson MA, Yen J (2023) Certification of Standard Reference Materials® 3389 Yohimbe‑Containing Solid Oral Dosage Form.  (National Institute of Standards and Technology, Gaithersburg, MD), NIST Special Publication (SP) 260-240.

Released April 17, 2024