Joseph DeSimone, Director
Institutes of Nanomedicine and Advanced Materials, Nanoscience, and Technology
University of North Carolina (Chapel Hill)
To translate promising molecular discoveries into benefits for patients, we are taking a pharmaco-engineering systems approach to develop the next generation of delivery systems with programmable multi-functional capability. Our laboratory has pioneered the development of a technique called PRINT (Particle Replication in Non-wetting Templates). PRINT is a top-down particle synthesis method that extends the nano-fabrication techniques from the semiconductor industry to a high throughput, continuous roll-to-roll process. PRINT enables the fabrication of precisely defined micro- and nano-particles with control over particle size (20 nm to >20 micron), shape, chemical composition, cargo (proteins, adjuvants, therapeutics, oligonucleotides, siRNA, imaging agents), modulus (stiff, deformable - RBC mimics) and surface chemistries (antibodies, PEG chains, metal chelators), including the spatial distribution of proteins on the particle. In the history of delivery, particles have never had the uniformity, precision and chemical and shape control afforded by PRINT.
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