This project is a collaborative effort between NCNR and a major pharmaceutical company.
We are looking for a highly motivated postdoctoral scientist to join us to study protein-protein
and protein-excipient interactions in concentrated protein formulations using scattering
techniques. The postdoc will have opportunities to work closely with industrial scientists as well
as collaborate with scientists on NIST campus. This position is open for US citizens only.
There is an urgent need to understand protein-protein and protein-excipient behavior in high-
concentration formulations sought in many pharmaceutical products. X-ray and neutron scattering
have been traditionally used to study long- and short-ranged interactions in a variety of polymer
and protein systems. Understanding interactions between monoclonal antibodies (mAbs) including
their anisotropic component is critical to accurately predict the properties of concentrated mAb
solutions, and model their stability and phase behavior. By closely working with industrial
scientists, this project aims to develop methods to extract anisotropic interaction models for
pharmaceutically relevant proteins. Combining the theoretical development, experimental efforts
using SANS and SAXS, and molecular simulation, we hope to significantly improve the accuracy
of anisotropic protein-protein interaction models used to understand mAb-based therapeutic
If interested, please feel free to contact Dr. Yun Liu (yun.liu [at] nist.gov ), Dr. Vincent Shen
(Vincent.shen [at] nist.gov ), Dr. Wick Hatch (harold.hatch [at] nist.gov) or Dr. Alexander Grishaev
(alexander.grishaev [at] nist.gov ).