Molecular characterization

News and Updates

Making the DNA Melt Curve More Accurate

August 18, 2020

DNA is not only the blueprint of life; it has become the backbone for making tiny structures that can be inserted into the human body to diagnose and treat

Atomic ‘Swiss Army Knife’ Precisely Measures Materials for Quantum Computers

July 6, 2020

It images single atoms. It maps atomic-scale hills and valleys on metal and insulating surfaces. And it records the flow of current across atom-thin materials

Probing the Origin of Alzheimer’s . . . with Transistors

August 7, 2019

A prime suspect in the onset of Alzheimer’s and Parkinson’s diseases is a normally benign enzyme that is essential to proper development of the nervous system

After 90 Years, a Better Way to Measure the Composition of Paper

February 14, 2019

Researchers at the National Institute of Standards and Technology (NIST), in collaboration with the U.S. Government Publishing Office (GPO), have developed a

Projects and Programs

Platform for Realizing Integrated Molecule Experiments (PRIME)

PRIME (Platform for Realizing Integrated Molecule Experiments) aims to establish primary, quantum-based realizations for both the radiometric watt and kelvin

HDX-MS for Biopharmaceutical Analysis

This project applies hydrogen/deuterium exchange mass spectrometry (HDX-MS) for determining the dynamical structure of therapeutic antibodies, glycoproteins

Advanced Materials: X-ray Science for Standards and Analysis

Advanced experimental and theoretical methods are developed to increase the accuracy and precision of X-ray line energies and information derived from X-ray

Secondary Ion Mass Spectrometry Ion Source Development

The use of cluster sources such as C60 and argon gas cluster ion beams (Ar GCIB) allow for the analysis of the subsurface volume. It can also minimize the

Publications

Conformational gating, dynamics and allostery in human monoacylglycerol lipase

October 28, 2020

Author(s)

Sergiy Tyukhtenko, Girija Rajarshi, Ioannis L. Karageorgos, Nikolai Zvonok, Kiran Vemuri, Jeffrey W. Hudgens, Xiaoyu Ma, Mahmoud L. Nasr, Alexandros Makriyannis, Kyle W. Anderson, Jason J. Guo, Gerhard Wagner

Inhibition of human Monoacylglycerol Lipase (hMGL) offers a novel approach for treating neurological diseases. The design of inhibitors, targeting active

Charge conductivity in donoracceptor polymer dispersions measured with time-resolved terahertz spectroscopy

October 5, 2020

Author(s)

Timothy J. Magnanelli, Edwin J. Heilweil

Ultrafast Time-Domain and Time-Resolved Terahertz (TDS/TRTS) spectroscopic methods are utilized to explore photoconductive properties of conjugated donor

Increasing the Coverage of a Mass Spectral Library of Milk Oligosaccharides Using a Hybrid- Search-Based Bootstrapping Method and Milks from a Wide Variety of Mammals

July 8, 2020

Author(s)

Concepcion A. Remoroza, Tytus D. Mak, Yuri A. Mirokhin, Sergey L. Sheetlin, Xiaoyu Yang, Stephen E. Stein, Power L. Michael, San Andres V. Joice, Yuxue Liang

This study significantly expands both the scope and method of identification for construction of a previously reported tandem mass spectral library of 74 human

Infrared and Raman chemical imaging and spectroscopy at the nanoscale

May 19, 2020

Author(s)

Dmitry Kurouski, Alexandre Dazzi, Renato Zenobi, Andrea Centrone

The advent of nanotechnology, and the need to understand the chemical composition at the nanoscale, has stimulated the convergence of IR and Raman spectroscopy

Tools and Instruments

Fourier Transform Infrared Spectroscopy

Fourier Transform Infrared (FTIR) Spectroscopy is a spectroscopic technique in which the vibrational modes of the molecules comprising a material of interest