Molecular characterization

News and Updates

NIST Puts New Biopharmaceutical Quality Control Method to the Test

March 29, 2021

A new method for monitoring biopharmaceutical product quality was recently put to the test by The National Institute of Standards and Technology (NIST) and 28

NIST Publishes a Beginner’s Guide to DNA Origami

January 8, 2021

In a technique known as DNA origami, researchers fold long strands of DNA over and over again to construct a variety of tiny 3D structures, including miniature

Making the DNA Melt Curve More Accurate

August 18, 2020

DNA is not only the blueprint of life; it has become the backbone for making tiny structures that can be inserted into the human body to diagnose and treat

Projects and Programs

NCNR DAC and CCUS efforts

Overview Capture of carbon dioxide from the air (direct air capture; DAC) combined with energy efficiency and carbon capture, utilization and storage (CCUS)

Platform for Realizing Integrated Molecule Experiments (PRIME)

PRIME (Platform for Realizing Integrated Molecule Experiments) aims to establish primary, quantum-based realizations for both the radiometric watt and kelvin

Advanced Materials: X-ray Science for Standards and Analysis

Advanced experimental and theoretical methods are developed to increase the accuracy and precision of X-ray line energies and information derived from X-ray

Secondary Ion Mass Spectrometry Ion Source Development

The use of cluster sources such as C60 and argon gas cluster ion beams (Ar GCIB) allow for the analysis of the subsurface volume. It can also minimize the

Publications

Recommendation system to predict missing adsorption properties of nanoporous materials

September 7, 2021

Author(s)

Arni Sturluson, Ali Raza, Grant McConachie, Daniel Siderius, Xaioli Fern, Cory Simon

Nanoporous materials (NPMs) selectively adsorb and concentrate gases into their pores and thus could be used to store, capture, and sense many different gases

Representing and Comparing Site-Specific Glycan Abundance Distributions of Glycoproteins

July 30, 2021

Author(s)

Concepcion Remoroza, Meghan Burke, Yi Liu, Yuri Mirokhin, Dmitrii Tchekhovskoi, Xiaoyu Yang, Stephen Stein

A method for representing and comparing distributions of N-linked glycans located at specific sites in proteins is presented. The representation takes the form

Open port sampling interface mass spectrometry of wipe-based explosives, oxidizers, and narcotics for trace contraband detection

July 19, 2021

Author(s)

Thomas Forbes, Jeffrey Lawrence, Changtong Hao, J Greg Gillen

Rapid screening for chemical traces of explosives and narcotics is widely used to support homeland security and law enforcement. These target compounds span a

Comprehensive Analysis of Tryptic Peptides Arising from Disulfide Linkages in NISTmAb and Their Use for Developing a Mass Spectral Library

June 22, 2021

Author(s)

Qian Dong, Xinjian Yan, Yuxue Liang, Sanford Markey, Sergey L. Sheetlin, Concepcion Remoroza, William E. Wallace, Stephen Stein

This work presents methods for identifying and then creating a mass spectral library for disulfide-linked peptides originating from the NISTmAb. Analysis

Tools and Instruments

Fourier Transform Infrared Spectroscopy

Fourier Transform Infrared (FTIR) Spectroscopy is a spectroscopic technique in which the vibrational modes of the molecules comprising a material of interest