Molecular characterization

News and Updates

A researcher stands on a boat reaching for a cable holding a grabber device.

NIST Releases Great Lakes Sediment Material for Measuring Organic Pollutants

November 23, 2021

People who live near the Great Lakes might go there to enjoy a swim or a boat ride. But if you’re visiting from the National Institute of Standards and

NIST Puts New Biopharmaceutical Quality Control Method to the Test

March 29, 2021

A new method for monitoring biopharmaceutical product quality was recently put to the test by The National Institute of Standards and Technology (NIST) and 28

NIST Publishes a Beginner’s Guide to DNA Origami

January 8, 2021

In a technique known as DNA origami, researchers fold long strands of DNA over and over again to construct a variety of tiny 3D structures, including miniature

Projects and Programs

NCNR DAC and CCUS efforts

Ongoing

Overview Capture of carbon dioxide from the air (direct air capture; DAC) combined with energy efficiency and carbon capture, utilization and storage (CCUS)

Platform for Realizing Integrated Molecule Experiments (PRIME)

Ongoing

PRIME (Platform for Realizing Integrated Molecule Experiments) aims to establish primary, quantum-based realizations for both the radiometric watt and kelvin

HDX-MS for Biopharmaceutical Analysis

Ongoing

This project applies hydrogen/deuterium exchange mass spectrometry (HDX-MS) for determining the dynamical structure of therapeutic antibodies, glycoproteins

Advanced Materials: Elemental and Chemical Analysis of Microstructured Materials

Ongoing

Electron, ion and photon-based microanalysis methods, instrumentation and protocols are developed to advance measurement science towards the elemental and

Publications

Mass Spectral Library Methods for Analysis of Site-Specific N-Glycosylation: Application to Human Milk Proteins

September 16, 2022

Author(s)

Concepcion Remoroza, Meghan Burke Harris, Xiaoyu (Sara) Yang, Sergey Sheetlin, Yuri Mirokhin, Sanford Markey, Dmitrii V. Tchekhovskoi, Stephen E. Stein

We present a mass-spectral library-based method for analyzing site-specific N-linked protein glycosylation. Its operation and utility are illustrated by

Chromatography at -30 °C for Reduced Back-Exchange, Reduced Carryover, and Improved Dynamic Range for Hydrogen-Deuterium Exchange Mass Spectrometry

June 22, 2022

Author(s)

Kyle Anderson, Jeffrey W. Hudgens

For hydrogen-deuterium exchange mass spectrometry (HDX-MS) to have an increased role in quality control of biopharmaceuticals, H for D back-exchange occurring

Three-Dimensional Molecular Orientation Imaging of a Semicrystalline Polymer Film under Shear Deformation

March 31, 2022

Author(s)

Young Jong Lee, Shuyu Xu, Chad R. Snyder, Jeremy Rowlette

The 3D molecular orientations of polymer chains are imaged and compared for a quiescent spherulite region and a shear deformed region of a semicrystalline poly

Comprehensive Data via Spectroscopy and Molecular Dynamics of Chemically Treated Graphene Nanoplatelets

March 30, 2022

Author(s)

Olasunbo Farinre, Hawazin Alghamdi, Mathew Kelley, Adam Biacchi, Albert Davydov, Christina Hacker, Albert Rigosi, Prabhakar Misra

Tools and Instruments

Fourier Transform Infrared Spectroscopy

Fourier Transform Infrared (FTIR) Spectroscopy is a spectroscopic technique in which the vibrational modes of the molecules comprising a material of interest