Molecular characterization

News and Updates

A graphical representation of a DNA biosensor device for clinical diagnostics that is the size and shape of a smartphone.

New DNA Biosensor Could Unlock Powerful, Low-Cost Clinical Diagnostics

January 24, 2023

The biosensor, developed by researchers at NIST, Brown University and the French research institute CEA-Leti , identifies biomarkers by measuring how binding

Molecules Have an Orientation, and Scientists Have a New Way to Measure It

December 8, 2022

Molecular orientation is key to designing better materials.

Research on the Rocks: Combining Neutrons and X-Ray Imaging, NIST Scientists Study Meteorites to Explore the Mystery of How Earth Acquired Its Water

November 3, 2022

Each year, hundreds of meteorites — rocky bodies left over from the formation of the solar system — bombard Earth, delivering minerals, metals and water to our

Projects and Programs

NCNR DAC and CCUS efforts

Ongoing

Overview Capture of carbon dioxide from the air (direct air capture; DAC) combined with energy efficiency and carbon capture, utilization and storage (CCUS)

NIST Tools for Cannabis Laboratory Quality Assurance

Ongoing

NIST has developed an integrated measurement services program for forensic and cannabis testing laboratories to help ensure the quality of routine analysis

Platform for Realizing Integrated Molecule Experiments (PRIME)

Ongoing

PRIME (Platform for Realizing Integrated Molecule Experiments) aims to establish primary, quantum-based realizations for both the radiometric watt and kelvin

Micronutrients Measurement Quality Assurance Program (MMQAP)

Completed

The Micronutrients Measurement Quality Assurance Program (MMQAP) was initiated in 1984 by the National Cancer Institute Division of Cancer Prevention and

Publications

High-Resolution Structural Characterization of Biomacromolecules in Aqueous Solutions from Extended q-range X-ray Scattering Data

January 16, 2023

Author(s)

Igor Levin, Alexander Grishaev, Fan Zhang, Jiahui Chen, Uta Ruett, Olaf Borkiewicz, Mrenal Bera

The Proteomics Standards Initiative at Twenty Years: Current Activities and Future Work

January 10, 2023

Author(s)

Eric Deutsch, Juan Antonio Vizcaino, Andrew Jones, Pierre-Alain Binz, Henry Lam, Joshua Klein, Wout Bittremeieux, Yasset Perez-Riverol, David Tabb, Mathias Walzer, Sylvie Ricard-Blum, Henning Hermjakob, Steffen Neumann, Tytus Mak, Shin Kawano, Luis Mendoza, Tim Van Den Bossche, Ralf Gabriels, Nuno Bandeira, Jeremy Carver, Benjamin Pullman, Zhi Sun, Nils Hoffman, Jim Shofstahl, Yunping Zhu, Federica Quaglia, Silvio Tosatto, Sandra Orchard

The Human Proteome Organization (HUPO) Proteomics Standards Initiative (PSI) has been successfully developing guidelines, data formats, and controlled

3D Orientation Imaging of Polymer Chains with Polarization-Controlled Coherent Raman Microscopy

December 7, 2022

Author(s)

Shuyu Xu, Young Jong Lee

Despite the ubiquity of three-dimensional (3D) anisotropic materials, their 3D molecular alignment cannot be measured using conventional two-dimensional (2D)

Unsupervised pharmaceutical polymorph identification and multicomponent particle mapping of ToF-SIMS data by non-negative matrix factorization

November 15, 2022

Author(s)

Thomas P. Forbes, J Greg Gillen, Amanda Souna, Jeffrey Lawrence

Crystal polymorphism of pharmaceutical compounds directly impacts resulting physicochemical characteristics, a critical aspect in active pharmaceutical

Tools and Instruments

Fourier Transform Infrared Spectroscopy

Fourier Transform Infrared (FTIR) Spectroscopy is a spectroscopic technique in which the vibrational modes of the molecules comprising a material of interest