Molecular characterization

News and Updates

A researcher stands on a boat reaching for a cable holding a grabber device.

NIST Releases Great Lakes Sediment Material for Measuring Organic Pollutants

November 23, 2021

People who live near the Great Lakes might go there to enjoy a swim or a boat ride. But if you’re visiting from the National Institute of Standards and

NIST Puts New Biopharmaceutical Quality Control Method to the Test

March 29, 2021

A new method for monitoring biopharmaceutical product quality was recently put to the test by The National Institute of Standards and Technology (NIST) and 28

NIST Publishes a Beginner’s Guide to DNA Origami

January 8, 2021

In a technique known as DNA origami, researchers fold long strands of DNA over and over again to construct a variety of tiny 3D structures, including miniature

Projects and Programs

NCNR DAC and CCUS efforts

Ongoing

Overview Capture of carbon dioxide from the air (direct air capture; DAC) combined with energy efficiency and carbon capture, utilization and storage (CCUS)

Platform for Realizing Integrated Molecule Experiments (PRIME)

Ongoing

PRIME (Platform for Realizing Integrated Molecule Experiments) aims to establish primary, quantum-based realizations for both the radiometric watt and kelvin

HDX-MS for Biopharmaceutical Analysis

Ongoing

This project applies hydrogen/deuterium exchange mass spectrometry (HDX-MS) for determining the dynamical structure of therapeutic antibodies, glycoproteins

Advanced Materials: Elemental and Chemical Analysis of Microstructured Materials

Ongoing

Electron, ion and photon-based microanalysis methods, instrumentation and protocols are developed to advance measurement science towards the elemental and

Publications

HDX-MS and MD simulations provide evidence for stabilization of the IgG1— FcγRIa (CD64a) immune complex through intermolecular glycoprotein bonds

December 8, 2021

Author(s)

Kyle Anderson, Kerry Scott, Christina Bergonzo, Ioannis Karageorgos, Elyssia Gallagher, Venkata Tayi, Michael Butler, Jeffrey W. Hudgens

Previous reports present different models for the stabilization of the Fc—FcγRI immune complex. Although accord exists on the importance of L235 in IgG1 and

Recommendation system to predict missing adsorption properties of nanoporous materials

September 7, 2021

Author(s)

Arni Sturluson, Ali Raza, Grant McConachie, Daniel Siderius, Xaioli Fern, Cory Simon

Nanoporous materials (NPMs) selectively adsorb and concentrate gases into their pores and thus could be used to store, capture, and sense many different gases

Representing and Comparing Site-Specific Glycan Abundance Distributions of Glycoproteins

July 30, 2021

Author(s)

Concepcion Remoroza, Meghan Burke, Yi Liu, Yuri Mirokhin, Dmitrii Tchekhovskoi, Xiaoyu Yang, Stephen Stein

A method for representing and comparing distributions of N-linked glycans located at specific sites in proteins is presented. The representation takes the form

Open port sampling interface mass spectrometry of wipe-based explosives, oxidizers, and narcotics for trace contraband detection

July 19, 2021

Author(s)

Thomas P. Forbes, Jeffrey Lawrence, Changtong Hao, J Greg Gillen

Rapid screening for chemical traces of explosives and narcotics is widely used to support homeland security and law enforcement. These target compounds span a

Tools and Instruments

Fourier Transform Infrared Spectroscopy

Fourier Transform Infrared (FTIR) Spectroscopy is a spectroscopic technique in which the vibrational modes of the molecules comprising a material of interest