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Clinical Quality Assurance Program


The National Institute of Standards and Technology (NIST) has established a Clinical Quality Assurance Program (ClinQAP) to support the measurement needs of the clinical community. The ClinQAP currently provides three comparability improvement programs that focus on specific classes of analytes in human serum and plasma matrices.


The Micronutrients Measurement Quality Assurance Program (MMQAP) was established in 1984 and provides comparability studies for laboratories that measure vitamins and carotenoids. The Vitamin D Metabolites Quality Assurance Program (VitDQAP) was initiated in 2009 as a collaboration with the National Institutes of Health Office of Dietary Supplements (NIH-ODS). Interlaboratory comparison studies of the VitDQAP are currently directed toward the measurement of 25-hydroxyvitamin D2, 25-hydroxyvitamin D3, and 3-epi-25-hydroxyvitamin D3 in selected serum and plasma matrices as well as method-appropriate control materials. Finally, the Fatty Acids in Human Serum and Plasma Quality Assurance Program (FAQAP) was established in 2012 to improve the comparability of fatty acids measurements and is also a collaboration with the NIH-ODS. In addition to providing comparability improvement programs, the ClinQAP also interacts with the measurement community to determine the emerging measurement challenges and provides interlaboratory assessments, as needed, to evaluate additional analytes and matrices. For example, an interlaboratory study to assess inorganic constituents in a human urine material designed for the metabolomics community is currently being planned. Because the ClinQAP is a measurement service provided to the clinical measurement community, we are actively seeking feedback regarding our program. If you would like to provide comments or questions to us, please see below, 'How to Contact Us' and 'ClinQAP Questionnaire.'

ClinQAP Questionnaire

The ClinQAP has developed a questionnaire requesting program feedback from current and potential QAP participants. Specifically, the questionnaire will be used to learn about clinical measurement needs and to assess the utility of the current comparability improvement programs. To participate in the ClinQAP questionnaire, please click HERE.

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If you are interested in learning more about our programs or providing feedback, please send an e-mail to clinqap@nist.gov.