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The Bioprocess Measurements Group develops measurement methods and standards that support a variety of application areas, particularly those relevant to biological industrial processes.
Areas of current active interest include:
Standards and new methods for counting and characterizing protein particles in biotherapeutics
Novel sensors for monitoring health and industrial manufacture of biological products
Innovative device platforms and signal processing methods
Affinity-based assays of the glycosylation (sugar decoration) patterns in biotherapeutic proteins
Protein conformation studies, in solution and adsorbed to surfaces.
We combine expertise in instrumentation science, nanomaterials, and chemical and physical characterization of surfaces, sensor materials, and biological molecules.
ROCKVILLE, Md. — The U.S. Department of Commerce’s National Institute of Standards and Technology (NIST), the National Institute for Innovation in Manufacturing
Understanding how proteins clump together is essential in modern pharmaceuticals. When these tiny particles aggregate, they can alter the effectiveness of both
Protein drugs are the top selling pharmaceuticals worldwide, a hundred billion dollar industry, but also the fastest growing category of health care costs. The
The Bioprocess Sensing Group at NIST is investigating a range of fundamental and technological issues related to next-generation chemical and biochemical
This project applies hydrogen/deuterium exchange mass spectrometry (HDX-MS) for determining the dynamical structure of therapeutic antibodies, glycoproteins
Advanced bonding and integration physically bring together components, devices, and materials that are produced separately. There are strong economic and
Chromatographic separations at subzero temperature significantly improve the precision of back-exchange corrected hydrogen−deuterium exchange mass spectrometry
Fei Liu, Alexander Greenwood, Yawei Xiong, Rebecca Miceli, Riqiang Fu, Kyle Anderson, Scott McCallum, Ella Mihailescu, Richard Gross, Myriam Cotten
Developing new antimicrobials as alternatives to conventional antibiotics has become an urgent race to eradicate drug-resistant bacteria and save human lives
Sean Lehman, Kurt D. Benkstein, Thomas Cleveland, Kyle Anderson, Michael J. Carrier, Wyatt N. Vreeland
Lipid nanoparticles are a type of nanomaterial with broad applicability in medicine as drug delivery vehicles. The lipid nanoparticle platform can be loaded
Zhishang Hu, Wei Mi, Chen Ye, Yun Zhao, Richard E. Cavicchi, Haiying Hang, Hongmei Li
Accurately quantifying the protein particles in both subvisible (1–100 μm) and submicron (≤1 μm) ranges remains a prominent challenge in the development and