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Displaying records 31 to 40 of 151 records.
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31. Cytochrome c at Model Membrane Surfaces: Exploration via Second Harmonic Generation - Circular Dichroism and Surface-Enhanced Resonance Raman Spectroscopy
Topic: Life Sciences Research
Published: 7/11/2000
Authors: T Petralli-Mallow, Anne L Plant, M Lewis, J Hicks
Abstract: The novel nonlinear optical method second harmonic generation-circular dichroism (SHG-CD) has been used to follow the adsorption and redox properties of a peripheral membrane protein horse heart cytochrome c, adsorbed at several model membrane surfac ...

32. Cytonectin Expression in Alzheimer's Disease
Topic: Life Sciences Research
Published: 3/1/2002
Authors: S J Anderson, Peter E. Dr. Barker, M G Hadfield
Abstract: Cytonectin is a novel 35,000 molecular weight protein that displays remarkable ion-independent adherence properties. This consigns it to a family of well-known adherence molecules essential for cell communication and the development of 3-dimensional ...

33. DNA Base Damage by the Antitumor Agent 3-Amino-1,2,4-Benzotriazine 1,4-Dioxide (Tirapazamine)
Topic: Life Sciences Research
Published: 9/24/2003
Authors: M Birincioglu, Pawel Jaruga, G Chowdhury, H Rodriguez, M Miral Dizdar, K Gates
Abstract: Tirapazamine is a bioreductively activated DNA-damaging agent that selectively kills the hypoxic cells found in solid tomors. This compound shows great clinical promise and is currently being examined in a variety of clinical trails, including sever ...

34. Damage, Repair and Mutagenesis in Nuclear Genes of the Brain after Forebrain Ischemia and Reperfusion
Topic: Life Sciences Research
Published: 12/1/1996
Authors: P K Liu, C Y Hsu, M Miral Dizdar, R A Floyd, Y W Kow, A Karakaya, L Rabow, J K Cui

35. Design and Use of a Peptide Nucleic Acid for Detection of the Heteroplasmic Low-Frequency Mitochondrial Encephalomyopathy, Lactic Acidosis, and Stroke-Like Episodes (MELAS) Mutation in Human Mitochondrial DNA
Topic: Life Sciences Research
Published: 12/1/2002
Authors: Diane K. Hancock, Frederick P. Schwarz, F H Song, L J Wong, Barbara C. Levin
Abstract: Most pathogenic human mitochondrial DNA (mtDNA) mutations are Heteroplasmic and are difficult to detect when present at very low levels in a population of normal mtDNA molecules. This paper describes a simple methodology to detect low levels of the s ...

36. Determination of Active Site Residues in Escherichia Coli Endonuclease VIII
Topic: Life Sciences Research
Published: 1/25/2002
Authors: S. M. Burgess, Pawel Jaruga, M L Dodson, M Miral Dizdar, R Stephen Lloyd
Abstract: Endonuclease VIII from Escherichia coli is a DNA glycosylase/lyase that removes oxidatively damaged bases. EndoVIII is a functional homologue of endonuclease III, but a sequence homologue of formamidopyrimidine DNA glycosylase (Fpg). Using multiple ...

37. Development of Standard Reference Materials for Diagnosis of P53 Mutations; Analysis by Slab Gel Single Strand Conformation Polymorphism
Topic: Life Sciences Research
Published: 2/1/1998
Authors: C D O'Connell, J Tian, A Juhasz, H M Wenz, Donald H Atha
Abstract: We have amplified by polymerase chain reaction (PCR) a 2.0 kbp region of the p53 gene containing exons 5-9 from seven cell lines reported in the literature to contain the majority of mutations reported for this gene. Sequence analysis of these produ ...

38. Differential Scanning Calorimetric Studies of the Glycoprotein, Winged Bean Acidic Lectin, Isolated from the Seeds of Psophocarpus Tetrogonolobus
Topic: Life Sciences Research
Published: 12/1/1998
Authors: V R Srinivasa, N C Singha, F P Schwarzm, A Surolia

39. Effect of Surface Chemistry on Stem Cell Response in 2-D vs. 3-D Cell Culture Niches
Topic: Life Sciences Research
Published: 4/19/2013
Authors: Sumona Sarkar, Carl George Simon Jr., Roberta I Lock, Joy P Dunkers
Abstract: To develop tissue engineered devices for regenerative medicine strategies, key scaffold properties for directing stem cell response must be identified. As focus shifts from 2-D to 3-D culture systems in an attempt to better recapitulate the na ...

40. Effect of the Distal C162S Mutation on the Energetics of Drug Binding to p38 alpha MAP Kinase
Topic: Life Sciences Research
Published: 1/15/2008
Authors: Niya Todorova, V Doseeva, Jayanthi Ramprakash, Frederick P. Schwarz
Abstract: The binding constant, Kb, and the binding enthalpy (DbHo) of the inhibitor drugs, SB 203580, SKF 86002, and p38 INH.1 binding to two splice variants of p38a MAP kinase and their C162S mutants in 5mM HEPES buffer at pH =7.4 were determined from isoth ...

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