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1. A General Model for the Dynamics of Cell Volume, Global Stability, and Optimal Control
Topic: Life Sciences Research
Published: 2/11/2011
Author: James D. Benson
Abstract: Cell volume and concentration regulation in the presence of changing extracellular environments has been studied for centuries, and recently a general nondimensional model was introduced that encompassed solute and solvent transmembrane flux for a wi ...

2. A New Measure in Cell Image Segmentation Data Analysis
Series: NIST Interagency/Internal Report (NISTIR)
Report Number: 7871
Topic: Life Sciences Research
Published: 7/24/2012
Authors: Jin Chu Wu, Michael W Halter, Raghu N Kacker, John T Elliott
Abstract: Cell image segmentation (CIS) is critical for quantitative imaging in cytometric analyses. The data derived after segmentation can be used to infer cellular function. To evaluate CIS algorithms, first for dealing with comparisons of single cells trea ...

3. Ab Initio Structure of the Active Site of Phosphotriesterase
Topic: Life Sciences Research
Published: 2/1/2001
Author: Morris Krauss
Abstract: This research exploits two recent developments to obtain a fundamental understanding of the metalloenzyme active site using the bi-metallic enzyme phosphotriesterase as an example of this class. First, is the theoretical prediction that the structure ...

4. Accumulation of (5'S)-8,5'-cyclo-2'-deoxyadenosine in organs of Cockayne syndrome complementation group B gene knockout mice
Topic: Life Sciences Research
Published: 2/1/2009
Authors: Guldal Kirkali, N de Souza-Pinto, Pawel Jaruga, V. Bohr, M Miral Dizdar
Abstract: Cockayne syndrome (CS) is a human genetic disorder characterized by sensitivity to UV radiation, neurodegeneration, premature aging among other phenotypes. CS complementary group B (CS-B) gene (csb) encodes the CSB protein (CSB) that is involved in b ...

5. Active Site Structure and Mechanism of Human Glyoxalase I - An Ab Initio Theoretical Study
Topic: Life Sciences Research
Published: 7/25/2001
Authors: U Richter, Morris Krauss
Abstract: The structure of the active site of human glyoxalase I and the reaction mechanism of the enzyme-catalyzed conversion of the thiohemiacetal, formed from methylglyoxal and glutathione, to S-D-lactoylglutathione has been investigated by ab initio quantu ...

6. Acylation of beta-lactams by class A beta-lactamases: an ab initio theoretical study on the effects of the oxy-anion hole
Topic: Life Sciences Research
Published: 7/9/1997
Authors: B D Wladkowski, S A Chenoweth, J N Sanders, Morris Krauss, W J. Stevens

7. Airbrushed Nanofiber Scaffolds Support Bone Marrow Stromal Cell Differentiation
Topic: Life Sciences Research
Published: 11/1/2013
Authors: Carl George Simon Jr., Wojtek J Tutak, Sumona Sarkar, Tanya M. Farooque, Jyotsnendu J. Giri, Dongbo Wang, Sheng Lin-Gibson, Joachim Kohn, Durgadas Bolikal
Abstract: Nanofiber scaffolds are effective for tissue engineering since they emulate the fibrous nanostructure of native extracellular matrix (ECM). Although electrospinning has been the most common approach for fabricating nanofiber scaffolds, airbrushi ...

8. An analytical framework for optimizing variant discovery from personal genomes
Topic: Life Sciences Research
Published: 2/25/2015
Authors: Justin M Zook, Gareth Highnam, Jason Wang, Dean Kusler, Vinaya Vijayan, Nir Leibovich, David Mittelman
Abstract: The standardization and performance testing of analysis tools is a prerequisite to widespread adoption of high-throughput sequencing, particularly in the clinic. However, performance testing is currently complicated by the paucity of standards and co ...

9. Application of NMR-based Metabolomics for Environmental Assessment in the Great Lakes using Zebra Mussel (Dreissena polymorpha) polymorpha)
Topic: Life Sciences Research
Published: 2/21/2015
Authors: Miki Watanabe, Katherine Meyer, Tyler Jackson, Tracey Beth Schock Schock, Ed Johnson, Daniel W Bearden
Abstract: Zebra mussel, Dreissena polymorpha, in the Great Lakes is being monitored as a bio-indicator organism for environmental health effects by the National Oceanic and Atmospheric Administration‰s Mussel Watch program. In order to monitor the enviro ...

10. Arabidopsis Thaliana Ogg1 Protein Excises 8-Hydroxyguanine and 2,6- Diamino-4-hydroxy-5-formamidopyrimidine from Oxidative Damaged DNA Containing Multiple Lesions
Topic: Life Sciences Research
Published: 3/18/2003
Authors: T Morales-Ruiz, M Birincioglu, Pawel Jaruga, H Rodriguez, T. Roldan-Arjona, M Miral Dizdar
Abstract: A functional homologue of eukaryotic Ogg1 proteins in the model plant Arabidopsis thaliana has recently been cloned, isolated, and characterized [Garcia-Ortiz, M.V., Ariza, R.R., and Roldan-Arjona, T. (2001) Plant Mol. Biol. 47, 795-804]. This enzym ...

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