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Topic Area: Life Sciences Research

Displaying records 1 to 10 of 266 records.
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1. Inward cholesterol gradient of the membrane system installed by malaria parasites in normal and sickle erythrocytes
Topic: Life Sciences Research
Published: 5/29/2014
Authors: Fuyuki Tokumasu, Georgeta Crivat, Hans Ackerman, Jeeseong Hwang, Thomas E. Wellems
Abstract: Plasmodium falciparum (Pf) infection remodels the human erythrocyte with new membrane systems, including a modified host erythrocyte membrane (EM), a parasitophorous vacuole membrane (PVM), a tubulovesicular network (TVN), and Maurer's clefts (MC ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=913652

2. Machine Learning Analysis for Identification of Cell Shape Metrics Associated with Stem Cell Differentiation in Nanofiber Scaffolds
Topic: Life Sciences Research
Published: 4/19/2014
Authors: Desu Chen, Sumona Sarkar, Stephen J Florczyk, Subhadip Bodhak, Carl George Simon Jr, Joy P Dunkers, Julian Candia, Wolfgang Losert
Abstract: Cell shape has been demonstrated to be closely related to cell function and may be an important predictor of cell fate. Many metrics are available to describe cell shape, however the relationship of these metrics to cell fate are not well understood ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=914971

3. Roles of Nanofiber Structure and Chemistry in Directing Stem Cell Morphology, Differentiation and Gene Expression
Topic: Life Sciences Research
Published: 4/19/2014
Authors: Sumona Sarkar, Bryan Alexander Baker, Desu Chen, Wolfgang Losert, Carl George Simon Jr, Joy P Dunkers
Abstract: Nanofiber technology has emerged as a promising tool to recapitulate the native extracellular matrix (ECM) environment for tissue engineering and regenerative medicine strategies. Cell-material interactions in the nanofiber system are largely de ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=914988

4. A Novel Mechanism for Regulating the Activity of Proliferating Cell Nuclear Antigen by a Small Protein
Topic: Life Sciences Research
Published: 3/10/2014
Authors: Zvi Kelman, Richard Y. Huang, Zhuo Li, Jerard Hurwitz, Santangelo J Thomas, Travis H Hileman, Yopp C Daniel, Jeffrey W Hudgens
Abstract: Chromosomal DNA replication requires the regulated activity of large number of proteins and complexes. Proliferating cell nuclear antigen (PCNA) protein forms a homotrimeric ring that associates with, and regulates the activity of, many proteins ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=914076

5. Improved Normalization of Systematic Biases Affecting Ion Current Measurements in Label-free Proteomics Data
Topic: Life Sciences Research
Published: 2/21/2014
Authors: Paul A Rudnick, Xinjian Yan, Stephen E Stein, Xia Wang, Nell Sedransk
Abstract: Systematic biases, or batch effects, in ,high-throughput‰ biological datasets can be described as obscuring variabilities introduced during experimental design or analytical processing. These biases, if left unresolved, can lead to misinterpreta ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=913822

6. Why human genome sequencing platforms differ: Integrating sequencing datasets to understand biases and form consensus variant calls
Topic: Life Sciences Research
Published: 2/16/2014
Authors: Justin M Zook, Brad Chapman, Winston Hide, Marc L Salit
Abstract: Hundreds of thousands of differences exist between human whole genome variant calls from different sequencing platforms and variant calling pipelines, but the reasons for these differences are poorly understood. Well-characterized whole genome Refer ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=912658

7. Airbrushed Nanofiber Scaffolds Support Bone Marrow Stromal Cell Differentiation
Topic: Life Sciences Research
Published: 11/1/2013
Authors: Carl George Simon Jr, Wojtek J Tutak, Sumona Sarkar, Tanya M. Farooque, Jyotsnendu (Jyotsnendu) Giri, Dongbo Wang, Sheng Lin-Gibson, Joachim Kohn, Durgadas Bolikal
Abstract: Nanofiber scaffolds are effective for tissue engineering since they emulate the fibrous nanostructure of native extracellular matrix (ECM). Although electrospinning has been the most common approach for fabricating nanofiber scaffolds, airbrushi ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=912293

8. Comprehensive analysis of protein digestion using six trypsins reveals the origin of trypsin as a significant source of variability in proteomics
Topic: Life Sciences Research
Published: 10/11/2013
Authors: Stephen E Stein, Paul A Rudnick, Scott J Walmsley, Qian Dong, Alexey I Nesvizhskii, Yuxue Liang
Abstract: Trypsin is an endoprotease commonly used for sample preparation in proteomics experiments. Importantly, protein digestion is dependent on multiple factors, including the trypsin origin and digestion conditions. In-depth characterization of tryp ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=914042

9. Total free energy governs cell morphology ‹ A possible solution to obtain intrinsic cell modulus
Topic: Life Sciences Research
Published: 9/26/2013
Authors: Martin Y Chiang, Yanzi Yangben , Nancy J Lin, Li Yang
Abstract: Cells adjust their morphology in response to physical and chemical interactions with their environment. In this report, we deem that the fundamental nature of free energies associated with cell/substrate interactions regulates adherent cell morpholog ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=909671

10. Measurement Uncertainty in Cell Image Segmentation Data Analysis
Series: NIST Interagency/Internal Report (NISTIR)
Report Number: 7954
Topic: Life Sciences Research
Published: 8/13/2013
Authors: Jin Chu Wu, Michael W Halter, Raghu N Kacker, John T Elliott, Anne L Plant
Abstract: Cell image segmentation is a part of quantitative studies regarding cell movement and cell behavior, and it plays a critical role in molecular biology and cellular biochemistry. Therefore, it is fundamentally important to evaluate the performance ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=914171



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