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You searched on: Topic Area: Medical Devices Sorted by: date

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1. Quantifying and Improving Clinical-grade Coverage and Accuracy using Augmented Exome Sequencing
Topic: Medical Devices
Published: 7/16/2015
Authors: Justin M Zook, Anil Patwardhan, Marc L Salit, Carlos Bustamante, Euan Ashley, Michael Snyder, John West, Richard Chen
Abstract: Exome sequencing is increasingly used for the clinical evaluation of genetic disease, yet accuracy and coverage in medically interpretable parts of the genome remains under-characterized. We evaluate recently developed exome sequencing platforms in t ...

2. Optimization of Next-Generation Sequencing Informatics Pipelines for Clinical Laboratory Practice
Topic: Medical Devices
Published: 7/8/2015
Authors: Justin M Zook, Amy Gargis, Lisa Kalman, Ira Lubin, Marc L Salit
Abstract: We direct your readers' attention to the principles and guidelines (see Supplementary Guidelines) developed by the Next-generation Sequencing: Standardization of Clinical Testing II (Nex-StoCT II) informatics workgroup, which was convened by the Cent ...

3. Validated Open Source Nanofiber Diameter Measurement Tool
Topic: Medical Devices
Published: 4/30/2015
Authors: Nathan A Hotaling, Kapil Bharti, Haydn Kriel, Carl George Simon Jr.
Abstract: Despite the growing use of nanofiber scaffolds for tissue engineering applications, there is not a validated, readily available (commercial or open source) solution for rapid, automated analysis of nanofiber diameter from scanning electron microscope ...

4. The Art in Science of MicroTAS: the 2014 issue
Topic: Medical Devices
Published: 4/14/2015
Author: Darwin R Reyes-Hernandez
Abstract: For the 7th year in a row the Art in Science award competition, sponsored by Lab on a Chip and the National Institute of Standards and Technology (NIST), took place at the 18th International Conference of Miniaturized Systems for Chemistry and Life S ...

5. Shape-changing magnetic assemblies as high-sensitivity NMR-readable nanoprobes
Topic: Medical Devices
Published: 4/2/2015
Authors: Gary Zabow, Stephen Dodd, Alan Koretsky
Abstract: Fluorescent and plasmonic probes have proven invaluable in the life sciences, but function poorly in optically inaccessible regions. Here we present radio-frequency addressable analogs that afford sensing opportunities similar to those of fluorescent ...

6. Genomic Reference Materials for Clinical Application
Topic: Medical Devices
Published: 11/21/2014
Authors: Justin M Zook, Marc L Salit
Abstract: Reference Materials are well-characterized, homogeneous, and stable samples that can be used to understand measurement performance. The Genome in a Bottle Consortium is developing whole human genome DNA Reference Materials from large batches of DNA ...

7. An Average Enumeration Method of Hyperspectral Imaging Data for Quantitative Evaluation of Medical Device Surface Contamination
Topic: Medical Devices
Published: 9/15/2014
Authors: Hanh Le, Moon Kim, Jeeseong Hwang, Yi Yang, Pawneena U-Thainual, Jin Kang, Do-Hyun Kim
Abstract: We propose a quantification method called Mapped Average Principal component analysis Score (MAPS) to enumerate the contamination coverage on common medical device surfaces. The method was adapted from conventional Principal Component Analysis (P ...

8. Machine Learning Analysis for Identification of Cell Shape Metrics Associated with Stem Cell Differentiation in Nanofiber Scaffolds
Topic: Medical Devices
Published: 4/19/2014
Authors: Desu Chen, Sumona Sarkar, Stephen J Florczyk, Subhadip Bodhak, Carl George Simon Jr., Joy P Dunkers, Julian Candia, Wolfgang Losert
Abstract: Cell shape has been demonstrated to be closely related to cell function and may be an important predictor of cell fate. Many metrics are available to describe cell shape, however the relationship of these metrics to cell fate are not well understood ...

9. Roles of Nanofiber Structure and Chemistry in Directing Stem Cell Morphology, Differentiation and Gene Expression
Topic: Medical Devices
Published: 4/19/2014
Authors: Sumona Sarkar, Bryan A. Baker, Desu Chen, Wolfgang Losert, Carl George Simon Jr., Joy P Dunkers
Abstract: Nanofiber technology has emerged as a promising tool to recapitulate the native extracellular matrix (ECM) environment for tissue engineering and regenerative medicine strategies. Cell-material interactions in the nanofiber system are largely de ...

10. Why human genome sequencing platforms differ: Integrating sequencing datasets to understand biases and form consensus variant calls
Topic: Medical Devices
Published: 2/16/2014
Authors: Justin M Zook, Brad Chapman, Winston Hide, Marc L Salit
Abstract: Hundreds of thousands of differences exist between human whole genome variant calls from different sequencing platforms and variant calling pipelines, but the reasons for these differences are poorly understood. Well-characterized whole genome Refer ...

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