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Topic Area: Drugs/Pharmaceuticals
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Displaying records 31 to 40 of 41 records.
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31. Quantitative Analysis of Dendron-Conjugated Cisplatin-Complexed Gold Nanoparticles Using Scanning Particle Mobility Mass Spectrometry
Topic: Drugs/Pharmaceuticals
Published: 5/8/2013
Authors: De-Hao D. Tsai, Tae Joon Cho, Sherrie R. Elzey, Julien C. Gigault, Vincent A Hackley
Abstract: We report a high-resolution and traceable method to quantify the drug loading on nanoparticle-based cancer therapeutics, and demonstrate this method using a model cisplatin functionalized dendron-gold nanoparticle (AuNP) conjugate. Electrospray diffe ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=912782

32. Recent Advances in Electrochemical Glyco-biosensing
Topic: Drugs/Pharmaceuticals
Published: 4/8/2011
Authors: Rebecca A Zangmeister, Germarie Sanchez-Pomales
Abstract: Biosensors based on electrochemical transduction mechanisms have recently made advances into the field of glycan analysis. These glyco-biosensor assays offer simple, rapid, sensitive and economical approaches to the measurement need for rapid glycan ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=908197

33. Semantic Web for the Life Sciences Hype, Why, How and Use Case for AIDS Inhibitors
Topic: Drugs/Pharmaceuticals
Published: 7/1/2007
Authors: Talapady N Bhat, John Barkley
Abstract: There is considerable interest in the Semantic Web as a solution to the growing information technology needs of biological data and drug discovery. However, the progress towards this vision has been very limited. One reason for this slow progress is ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=830549

34. Solid State Chemistry of Proteins: II. The Correlation of Storage Stability of Freeze-Dried Human Growth Hormone (hGH) With Structure and Dynamics in the Glassy Solid
Topic: Drugs/Pharmaceuticals
Published: 12/1/2008
Authors: Michael Pikal, Daniel Rigsbee, Michael L Roy, Dawn Galreath, Karl J Kovach, Bingquan S. Wang, John F Carpenter, Marcus T Cicerone
Abstract: This research presents storage stability of human growth hormone, hGH, in a variety of lyophilized formulations, including systems of varying sugar:hGH weight ratios for both sucrose and trehalose. Stability was assessed at multiple time points durin ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=852769

35. Standards for the Optical Detection of Protein Particulates
Topic: Drugs/Pharmaceuticals
Published: 1/23/2012
Authors: Dean C Ripple, Michael J Carrier, Joshua R. Wayment
Abstract: Particulates in protein therapeutics, composed of agglomerated protein monomers, may cause an immunogenic response in patients. Consequently, industry and the FDA desire more accurate methods for counting and characterizing particulates. Unlike lik ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=908731

36. Structural Calcium (Trypsin, Subtilisin)
Topic: Drugs/Pharmaceuticals
Published: Date unknown
Authors: G L. Gilliland, A Teplyakov
Abstract: There are about 40 families of serine proteases defined by amino acid sequence similarities that can be further grouped into 7 clans on the basis of their tertiary structure and the order of the catalytic triad.^u1^ Members of clans SA and SB are c ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=830437

37. Study of interaction of the cyclin-dependent kinase 5 with its activator, p25 and with the p25-derived inhibitor, CIP
Series: NIST Interagency/Internal Report (NISTIR)
Report Number: 7552
Topic: Drugs/Pharmaceuticals
Published: 1/15/2009
Authors: Antonio Cardone, Ram D Sriram, Wayne Albers, Harish C. Pant
Abstract: A high-affinity inhibitor protein called CIP, which can be produced by small truncations of p35, was earlier identified by Amin, Albers, and Pant. P35 is one of the physiological activators of cdk5, a member of the cyclin-dependent kinase family. The ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=901184

38. Testing for the Antiphospholipid Syndrome: Importance of IgA Anti-beta 2-glycoprotein I
Topic: Drugs/Pharmaceuticals
Published: 12/17/2000
Authors: T.P. Greco, Michael D. Amos, A.M. Conti-Kelly, J.D. Naranjo, J.W. Ijdo
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=901236

39. The Metrology of Counting Protein Particles
Topic: Drugs/Pharmaceuticals
Published: 3/18/2013
Authors: Dean C Ripple, Michael J Carrier, Richard E Cavicchi, Christopher B Montgomery, Zhishang Hu
Abstract: A common degradation pathway for protein-based drugs is the growth of protein aggregates or particles. Counting and characterization of these particles is needed to assure the quality, efficacy, and safety of this type of drug. The unusual physical ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=913322

40. Tumor Necrosis Factor Interaction with Gold Nanoparticles
Topic: Drugs/Pharmaceuticals
Published: 3/14/2012
Authors: De-Hao D. Tsai, Sherrie R. Elzey, Frank W DelRio, Robert I. MacCuspie, Suvajyoti S. Guha, Michael Russel Zachariah, Athena M Keene, Jeffrey D Clogston, Vincent A Hackley
Abstract: We report on a systematic investigation of molecular conjugation of tumor necrosis factor protein-α (TNF) onto gold nanoparticles (AuNPs) and the subsequent binding behavior to its antibody (anti-TNF). We employ a combination of physical and spe ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=909899



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