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Topic Area: Drugs/Pharmaceuticals
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Displaying records 1 to 10 of 48 records.
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1. Structural Basis for Inactivation of Giardia lamblia Carbamate Kinase by Disulfiram
Topic: Drugs/Pharmaceuticals
Published: 4/11/2014
Authors: Andrey Galkin, Liudmila Kulakova, Kap Lim, Catherine Chen, Wei Zhang, Illarion V Turko, Osnat Herzberg
Abstract: Carbamate kinase from Giardia lamblia is an essential enzyme for the survival of the organism. The enzyme catalyzes the final step in the arginine dihydrolase pathway converting ADP and carbamoyl phosphate to ATP and carbamate. We previously repo ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=915235

2. Microfluidic-Enabled of Liposomes Elucidate Size-Dependent Transdermal Transport
Topic: Drugs/Pharmaceuticals
Published: 3/21/2014
Authors: Wyatt N Vreeland, Renee R Hood, Eric Kendall, Don L. DeVoe, Julia Finkel, Mariana Junqueira, Zenaide Quezado
Abstract: Microfluidic synthesis of small and nearly-monodisperse liposomes is used to investigate the size-dependent passive transdermal transport of nanoscale lipid vesicles. While large liposomes with diameters above 105 nm are found to be excluded from dee ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=915017

3. Facile Smiles-type rearrangement in radical cations of N-acyl arylsulfonamides and analogs
Topic: Drugs/Pharmaceuticals
Published: 1/21/2014
Authors: Karl K Irikura, Nino Guram Todua
Abstract: RATIONALE: N-Alkylation of sulfonylbenzamides was reported recently to cause a dramatic and surprising change in electron ionization mass spectrometry (EIMS), leading to a closed-shell base peak. Only an incomplete, speculative mechanism was availabl ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=912656

4. Determining carbapenemase activity with 18O labeling and targeted mass spectrometry
Topic: Drugs/Pharmaceuticals
Published: 10/16/2013
Authors: Meiyao Wang, Yang Shen, Illarion V Turko, Daniel Nelson, Shuwei Li
Abstract: Carbapenems are broad spectrum antibiotics considered as last resort drugs to treat bacterial infections. Carbapenem-hydrolyzing β-lactamases (also called carbapenemases), however, can confer bacterial resistance and represent a serious health t ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=914525

5. Microfluidic preparation of liposomes to determine particle size influence on cellular uptake mechanisms
Topic: Drugs/Pharmaceuticals
Published: 10/3/2013
Authors: Wyatt N Vreeland, Abhay U Andar, Renee R Hood, Don L. DeVoe, Peter W Swaan
Abstract: Purpose: This study investigates the cellular uptake and trafficking of liposomes in Caco-2 cells, using vesicles with distinct average diameters ranging from 40 nm-276 nm. Liposomes were prepared by microfluidic hydrodynamic flow focusing, producing ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=913538

6. Effects of Desialylation on Human alpha1-Acid Glycoprotein-Ligand Interactions
Topic: Drugs/Pharmaceuticals
Published: 9/16/2013
Authors: Richard Y. Huang, Jeffrey W Hudgens
Abstract: Human α1-Acid Glycoprotein (AGP), an acute phase glycoprotein, exists predominantly in blood. With its ability to bind basic, lipophilic, and acidic drugs, AGP has served as a drug carrier. It has been shown that the carbohydrate composition of ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=914495

7. TLR stimulation initiates a CD39-based autoregulatory mechanism that limits macrophage inflammatory responses
Topic: Drugs/Pharmaceuticals
Published: 9/12/2013
Authors: John P Marino, Katharine Therese Briggs, Heather Cohen, Katya Ravid, Simon C. Robson, David M. Mosser
Abstract: Sepsis is a highly fatal disease caused by an initial hyperinflammatory response followed by a state of profound immunosuppression. Although it is well appreciated that the initial production of proinflammatory cytokines by macrophages accompanies th ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=912870

8. Multicomponent Chemical Imaging of Pharmaceutical Solid Dosage Forms with Broadband CARS Microscopy
Topic: Drugs/Pharmaceuticals
Published: 7/15/2013
Authors: Christopher Michael Hartshorn, Marcus T Cicerone, Young Jong Lee, Charles H Camp, John Heddleston, Patrick Marsac, Tim Rhodes, Zhen Liu, Nicole Canfield
Abstract: We compare broadband coherent anti-Stokes Raman scattering (BCARS) microscopy with spontaneous Raman microscopy for quantitative and qualitative assessment of multicomponent pharmaceuticals. Indomethacin was used as a model active pharmaceutical ingr ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=913135

9. Microfluidic Synthesis of Nano-Liposomal Anesthetics
Topic: Drugs/Pharmaceuticals
Published: 5/12/2013
Authors: Wyatt N Vreeland, Renee R Hood, Eric Kendall, Mariana Junqueira, Julia Finkel, Don L. DeVoe
Abstract: Topical anesthesia has the ability to provide painless application of pain management medications for minor procedures such as venipuncture, particularly in the pediatric population. Liposomes have been proposed as a highly advantageous nanocarrier f ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=913770

10. Quantitative Analysis of Dendron-Conjugated Cisplatin-Complexed Gold Nanoparticles Using Scanning Particle Mobility Mass Spectrometry
Topic: Drugs/Pharmaceuticals
Published: 5/8/2013
Authors: De-Hao D. Tsai, Tae Joon Cho, Sherrie R. Elzey, Julien C. Gigault, Vincent A Hackley
Abstract: We report a high-resolution and traceable method to quantify the drug loading on nanoparticle-based cancer therapeutics, and demonstrate this method using a model cisplatin functionalized dendron-gold nanoparticle (AuNP) conjugate. Electrospray diffe ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=912782



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