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Topic Area: Drugs/Pharmaceuticals

Displaying records 21 to 30 of 54 records.
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21. Evaluation of viability and proliferation profiles on macrophages treated with silica nanoparticles in vitro via plate-based, flow cytometry, and Coulter counter assays
Topic: Drugs/Pharmaceuticals
Published: 9/3/2012
Authors: Simona Bancos, De-Hao D. Tsai, Vincent A Hackley, J L Weaver, Katherine M Tyner
Abstract: Nanoparticles (NPs) are known to interfere with many high throughput cell viability and cell proliferation assays, which complicates the assessment of their potential toxic effects. The aim of this study was to compare viability and proliferation res ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=911765

22. Thermal Analysis of Refrigeration Systems Used for Vaccine Storage
Topic: Drugs/Pharmaceuticals
Published: 8/2/2012
Authors: Michal J Chojnacky, Gregory F Strouse
Abstract: The CDC administers over $3 billion worth of vaccines per year through the Vaccines for Children program. Vaccine storage temperature is critical to maintaining drug potency, and as much as one-third of delivered vaccines are wasted due to thermal e ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=906174

23. Thermal Analysis of Refrigeration Systems Used for Vaccine Storage: Report on Pharmaceutical Grade Refrigerator and Household Refrigerator/Freezer
Series: NIST Interagency/Internal Report (NISTIR)
Topic: Drugs/Pharmaceuticals
Published: 8/2/2012
Authors: Michal J Chojnacky, W Wyatt Miller
Abstract: Each year, billions of dollars of vaccines are stored in refrigerators at the facilities of a variety of medical providers. Many vaccines must be maintained in the range 2 °C to 8 °C to retain product potency. We have tested the performance of two ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=907377

24. Monte Carlo and dynamics simulations of cdk5 Kinase inhibitor peptides p5 in aqueous solution
Topic: Drugs/Pharmaceuticals
Published: 7/20/2012
Authors: Antonio Cardone, Sergio Hassan, Mary C Brady, Ram D Sriram, Harish C. Pant
Abstract: Protein function depends on shape changes that are triggered by interactions with other molecules. Insights into protein dynamics and interactions enable the understanding of certain pathologies, which may be caused by the deregulation of protein ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=911466

25. Protein Particles: What We Know and What We Don‰t Know
Topic: Drugs/Pharmaceuticals
Published: 6/26/2012
Authors: Dean C Ripple, Mariana Dimitrova
Abstract: All therapeutic protein products contain particles formed by the aggregation of protein monomers. There is a growing interest in the understanding of particles in biopharmaceutical products, which has been fostered on the one hand by significant ad ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=910991

26. Probing the Nature of Ibuprofen Confined in Mesoporous Media by Neutron Vibrational Spectroscopy and First-Principles Calculations
Topic: Drugs/Pharmaceuticals
Published: 5/15/2012
Author: Ken Kangyi Qian
Abstract: {B}Purpose{/B}: In this paper, the nature of ibuprofen incorporated into both mesoporous silicon dioxide and magnesium aluminometasilicate by sublimation and adsorption was investigated using neutron vibrational spectroscopy. {B}Methods{/B}: Crystall ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=910370

27. A Lectin-Based Gold Nanoparticle Assay for Probing Glycosylation of Glycoproteins
Topic: Drugs/Pharmaceuticals
Published: 4/17/2012
Authors: Germarie Sanchez-Pomales, Todd A. Morris, James Falabella, Michael J Tarlov, Rebecca A Zangmeister
Abstract: We report a glycoanalysis method in which lectins are used to probe the glycans of glycoproteins that are adsorbed on gold nanoparticles. A model mannose-presenting glycoprotein, ribonuclease B (RNase B), and the therapeutic monoclonal antibody (mAb) ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=909549

28. Tumor Necrosis Factor Interaction with Gold Nanoparticles
Topic: Drugs/Pharmaceuticals
Published: 3/14/2012
Authors: De-Hao D. Tsai, Sherrie R. Elzey, Frank W DelRio, Robert I. MacCuspie, Suvajyoti S. Guha, Michael Russel Zachariah, Athena M Keene, Jeffrey D Clogston, Vincent A Hackley
Abstract: We report on a systematic investigation of molecular conjugation of tumor necrosis factor protein-α (TNF) onto gold nanoparticles (AuNPs) and the subsequent binding behavior to its antibody (anti-TNF). We employ a combination of physical and spe ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=909899

29. Standards for the Optical Detection of Protein Particulates
Topic: Drugs/Pharmaceuticals
Published: 1/23/2012
Authors: Dean C Ripple, Michael J Carrier, Joshua R. Wayment
Abstract: Particulates in protein therapeutics, composed of agglomerated protein monomers, may cause an immunogenic response in patients. Consequently, industry and the FDA desire more accurate methods for counting and characterizing particulates. Unlike lik ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=908731

30. Predictive Gold Nanocluster Formation Controlled by Metal-Ligand Complexes
Topic: Drugs/Pharmaceuticals
Published: 1/9/2012
Authors: John M Pettibone, Jeffrey W Hudgens
Abstract: The formation of ligand-protected transition metal nanoclusters in size-selective syntheses is driven by the inherent properties of the protecting ligands. We have previously reported the selective, monodisperse product formation of phosphine protect ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=908225



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