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Topic Area: Biomaterials
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Displaying records 51 to 60 of 91 records.
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51. Freeform Fabricated Scaffolds with Roughened Struts that Enhance both Stem Cell Proliferation and Differentiation by Controlling Cell Shape
Topic: Biomaterials
Published: 3/1/2012
Authors: Girish Kumar, Carl George Simon Jr, Michael S. (Michael Stephan) Waters, Tanya M. Farooque, Marian F Young
Abstract: We demonstrate that imparting freeform fabricated (FFF) scaffolds with surface roughness on their struts enhances osteogenic differentiation of primary human bone marrow stromal cells (hBMSCs) by controlling cell shape. Previous work showed that hBM ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=910664

52. Morphological Changes Driven by Nanofibrous Scaffolds Induce Marrow Stromal Cell Osteogenesis
Topic: Biomaterials
Published: 10/11/2011
Authors: Carl George Simon Jr, Kaushik Chatterjee, Christopher K. Tison, Girish Kumar, Patrick S Pine, Marc L Salit, Jennifer H McDaniel, Marian F Young
Abstract: Cells are sensitive to tissue scaffold architecture and these cell-material interactions drive cell functions critical in tissue regeneration. Results presented here demonstrate that nanofiber scaffolds force primary human bone marrow stromal cells ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=908027

53. Hybrid Cell Adhesive Material for Instant Dielectrophoretic Cell Trapping and Long Term Cell Function Assessment
Topic: Biomaterials
Published: 8/16/2011
Authors: Darwin R Reyes-Hernandez, Jennifer S. Hong, John T Elliott, Michael Gaitan
Abstract: We present the development and evaluation of an engineered hybrid cell adhesive surface for instant dielectrophoretic trapping and patterning of cells in a microfluidic device. This work demonstrates that a hybrid cell adhesive material (hCAM) prepar ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=906647

54. Combinatorial Screening of Osteoblast Response to 3D Nano-Composite Tissue Scaffolds Using Gradients and Arrays
Topic: Biomaterials
Published: 4/24/2011
Authors: Carl George Simon Jr, Kaushik Chatterjee, Limin Sun, Laurence Chung Lung Chow, Marian F Young
Abstract: Current methods for combinatorial and high-throughput (CHT) screening of cell-material interactions utilize a two-dimensional (2D) format where cells are presented on flat materials surfaces [1]. However, cell response in 3D scaffolds is more represe ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=907330

55. Effect of 3D Scaffold Structure on Osteogenic Differentiation of Human Bone Marrow Stromal Cells
Topic: Biomaterials
Published: 4/24/2011
Authors: Carl George Simon Jr, Girish Kumar, Marian F Young
Abstract: Structural properties of polymeric scaffolds for tissue engineering play a key role in directing osteogenesis. These properties depend on the chemical nature and the fabrication process of biomaterial. There are many protocols for fabricating scaff ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=907329

56. NIST Reference Material Scaffolds Characterized for Cell Response
Topic: Biomaterials
Published: 4/24/2011
Authors: Carl George Simon Jr, Jeff M Coles
Abstract: Reference scaffolds characterized for cell response are being developed for use as a standard for biological characterization of new scaffolds. The need for reference scaffolds to serve as a calibration standard between labs has been identified as c ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=907327

57. Nanofiber Scaffolds Induce Morphological Changes in hBMSCs Critical for Osteogenic Differentiation
Topic: Biomaterials
Published: 4/24/2011
Authors: Carl George Simon Jr, Girish Kumar, Christopher K. Tison
Abstract: Utilizing tissue scaffold architecture to induce stem cell differentiation is of tremendous importance to the regenerative medicine community. To this end, we have investigated the effect of nanofiber scaffold structure on primary human bone marrow s ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=907328

58. Osteoblast Response to Protein Adsorption to 3D Polymer Scaffolds Through Pre-Ageing in Cell Medium
Topic: Biomaterials
Published: 4/24/2011
Authors: Carl George Simon Jr, Kaushik Chatterjee, Stevephen Hung
Abstract: Protein adsorption mediates biological responses to materials. When a biodegradable polymer scaffold is placed in aqueous, physiological medium, proteins adsorb onto the scaffold surface. The total amount, composition and structure of the adsorbed pr ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=907331

59. Modulus-Driven Differentiation of Marrow Stromal Cells in 3D Is Independent of Cytoskeletal Integrity
Topic: Biomaterials
Published: 4/11/2011
Authors: Carl George Simon Jr, Kaushik Chatterjee, Sapun Parekh, Sheng Lin-Gibson, Nicole M. Moore, Marcus T Cicerone, Marian F Young
Abstract: Cell functions such as proliferation, migration, and differentiation are key physiological processes that are influenced by the physiochemical extracellular environment. We report on the effect of three-dimensional (3D) scaffold modulus on human bon ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=907017

60. Effect of 3D Hydrogel Scaffold Stiffness on Human Bone Marrow Stromal Cell Differentiation
Topic: Biomaterials
Published: 11/1/2010
Authors: Carl George Simon Jr, Sapun Parekh, Marcus T Cicerone, Sheng Lin-Gibson, Kaushik Chatterjee, Marian F Young
Abstract: There is growing recognition cells can sense and respond to the mechanical properties of tissue scaffolds and that these interactions are critical in optimizing scaffold design [1-4]. Previous studies in planar 2D culture format have shown that human ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=906309



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