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Displaying records 51 to 60 of 66 records.
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51. Combinatorial Screening of Osteoblast Response to 3D Nano-Composite Tissue Scaffolds Using Gradients and Arrays
Topic: Biomaterials
Published: 4/24/2011
Authors: Carl George Simon Jr., Kaushik Chatterjee, Limin Sun, Laurence Chung Lung Chow, Marian F Young
Abstract: Current methods for combinatorial and high-throughput (CHT) screening of cell-material interactions utilize a two-dimensional (2D) format where cells are presented on flat materials surfaces [1]. However, cell response in 3D scaffolds is more represe ...

52. Effect of 3D Scaffold Structure on Osteogenic Differentiation of Human Bone Marrow Stromal Cells
Topic: Biomaterials
Published: 4/24/2011
Authors: Carl George Simon Jr., Girish Kumar, Marian F Young
Abstract: Structural properties of polymeric scaffolds for tissue engineering play a key role in directing osteogenesis. These properties depend on the chemical nature and the fabrication process of biomaterial. There are many protocols for fabricating scaff ...

53. NIST Reference Material Scaffolds Characterized for Cell Response
Topic: Biomaterials
Published: 4/24/2011
Authors: Carl George Simon Jr., Jeff M Coles
Abstract: Reference scaffolds characterized for cell response are being developed for use as a standard for biological characterization of new scaffolds. The need for reference scaffolds to serve as a calibration standard between labs has been identified as c ...

54. Nanofiber Scaffolds Induce Morphological Changes in hBMSCs Critical for Osteogenic Differentiation
Topic: Biomaterials
Published: 4/24/2011
Authors: Carl George Simon Jr., Girish Kumar, Christopher K. Tison
Abstract: Utilizing tissue scaffold architecture to induce stem cell differentiation is of tremendous importance to the regenerative medicine community. To this end, we have investigated the effect of nanofiber scaffold structure on primary human bone marrow s ...

55. Osteoblast Response to Protein Adsorption to 3D Polymer Scaffolds Through Pre-Ageing in Cell Medium
Topic: Biomaterials
Published: 4/24/2011
Authors: Carl George Simon Jr., Kaushik Chatterjee, Stevephen Hung
Abstract: Protein adsorption mediates biological responses to materials. When a biodegradable polymer scaffold is placed in aqueous, physiological medium, proteins adsorb onto the scaffold surface. The total amount, composition and structure of the adsorbed pr ...

56. Modulus-Driven Differentiation of Marrow Stromal Cells in 3D Is Independent of Cytoskeletal Integrity
Topic: Biomaterials
Published: 4/11/2011
Authors: Carl George Simon Jr., Kaushik Chatterjee, Sapun Parekh, Sheng Lin-Gibson, Nicole M. Moore, Marcus T Cicerone, Marian F Young
Abstract: Cell functions such as proliferation, migration, and differentiation are key physiological processes that are influenced by the physiochemical extracellular environment. We report on the effect of three-dimensional (3D) scaffold modulus on human bon ...

57. Effect of 3D Hydrogel Scaffold Stiffness on Human Bone Marrow Stromal Cell Differentiation
Topic: Biomaterials
Published: 11/1/2010
Authors: Carl George Simon Jr., Sapun Parekh, Marcus T Cicerone, Sheng Lin-Gibson, Kaushik Chatterjee, Marian F Young
Abstract: There is growing recognition cells can sense and respond to the mechanical properties of tissue scaffolds and that these interactions are critical in optimizing scaffold design [1-4]. Previous studies in planar 2D culture format have shown that human ...

58. Fine-tuning of polymeric resins and their interfaces with amorphous calcium phosphate. A strategy for designing effective remineralizing dental composites
Topic: Biomaterials
Published: 9/29/2010
Authors: Joseph M Antonucci, Drago Skrtic
Abstract: For over a decade our group has been designing, preparing and evaluating bioactive, remineralizing composites based on amorphous calcium phosphate (ACP) fillers embedded in polymerized methacrylate resin matrices. In these studies a major focus has b ...

59. Combinatorial Screening of Hydrogels for 3-D Cell Culture: Osteoblasts in Stiffness Gradients Yield Graded Tissues
Topic: Biomaterials
Published: 7/1/2010
Authors: Kaushik Chatterjee, Sheng Lin-Gibson, William E Wallace III, Marian F Young, Carl George Simon Jr.
Abstract: A combinatorial library approach was used to demonstrate that hydrogel scaffold modulus can enhance osteoblast differentiation driving formation of a 3-D graded tissue construct. Though many previous studies have focused on screening cell-material i ...

60. Tooth chipping can reveal bite forces and diets of fossil hominins
Topic: Biomaterials
Published: 6/16/2010
Authors: Paul Constantino, James J. Lee, H Chai, Bernhard Zipfel, Charles Ziscovici, Brian Ronald Lawn, Peter Lucas
Abstract: Fossil hominin tooth enamel often exhibits antemortem edge chipping (Robinson 1954; Tobias 1967; Wallace 1973). Here we apply a simple fracture equation to estimate peak bite forces from the sizes of such chips. This equation, previously validated ...

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