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You searched on: Topic Area: Life Sciences Research

Displaying records 1 to 10 of 149 records.
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1. Optimization of Next-Generation Sequencing Informatics Pipelines for Clinical Laboratory Practice
Topic: Life Sciences Research
Published: 7/8/2015
Authors: Justin M Zook, Amy Gargis, Lisa Kalman, Ira Lubin, Marc L Salit
Abstract: We direct your readers' attention to the principles and guidelines (see Supplementary Guidelines) developed by the Next-generation Sequencing: Standardization of Clinical Testing II (Nex-StoCT II) informatics workgroup, which was convened by the Cent ...

2. Best Practices for Evaluating Single Nucleotide Variant Calling Methods for Microbial Genomics
Topic: Life Sciences Research
Published: 7/7/2015
Authors: Nathanael D Olson, Steven P Lund, Rebecca Colman, Jeffery T. Foster, Jason W. Sahl, James M. Schupp, Paul Keim, Jayne B Morrow, Marc L Salit, Justin M Zook
Abstract: Innovations in sequencing technologies have allowed biologists to make incredible advances in understanding biological systems. As experience grows, researchers increasingly recognize that analyzing the wealth of data provided by these new sequen ...

3. Quantitative scheme for full-field polarization rotating fluorescence microscopy (PROM) using a liquid crystal variable retarder
Topic: Life Sciences Research
Published: 5/14/2015
Authors: John F. Lesoine, Ji Y. Lee, Hyeong Gon (Hyeonggon) Kang, Matthew Lawrence Clarke, Robert C. Chang, Ralph Nossal, Jeeseong Hwang
Abstract: We introduce real-time, full-field, polarization rotating fluorescence microscopy (PROM) to monitor the absorption dipole orientations of fluorescent molecules. A quarter-wave plate, in combination with a liquid crystal variable retarder (LCVR ...

4. Validated Open Source Nanofiber Diameter Measurement Tool
Topic: Life Sciences Research
Published: 4/30/2015
Authors: Nathan A Hotaling, Kapil Bharti, Haydn Kriel, Carl George Simon Jr.
Abstract: Despite the growing use of nanofiber scaffolds for tissue engineering applications, there is not a validated, readily available (commercial or open source) solution for rapid, automated analysis of nanofiber diameter from scanning electron microscope ...

5. Quantitative Mass Spectrometry Measurements Reveal Stoichiometry of Principal Postsynaptic Density Protein Components
Topic: Life Sciences Research
Published: 4/28/2015
Authors: Mark S Lowenthal, Sanford Philip Markey, Ayse Dosemeci
Abstract: Quantitative studies are presented of postsynaptic density (PSD) fractions from rat cerebral cortex with the ultimate goal of defining the average copy numbers of proteins in the PSD complex. Highly specific and selective isotope dilution mass spectr ...

6. The Art in Science of MicroTAS: the 2014 issue
Topic: Life Sciences Research
Published: 4/14/2015
Author: Darwin R Reyes-Hernandez
Abstract: For the 7th year in a row the Art in Science award competition, sponsored by Lab on a Chip and the National Institute of Standards and Technology (NIST), took place at the 18th International Conference of Miniaturized Systems for Chemistry and Life S ...

7. An analytical framework for optimizing variant discovery from personal genomes
Topic: Life Sciences Research
Published: 2/25/2015
Authors: Justin M Zook, Gareth Highnam, Jason Wang, Dean Kusler, Vinaya Vijayan, Nir Leibovich, David Mittelman
Abstract: The standardization and performance testing of analysis tools is a prerequisite to widespread adoption of high-throughput sequencing, particularly in the clinic. However, performance testing is currently complicated by the paucity of standards and co ...

8. Application of NMR-based Metabolomics for Environmental Assessment in the Great Lakes using Zebra Mussel (Dreissena polymorpha) polymorpha)
Topic: Life Sciences Research
Published: 2/21/2015
Authors: Miki Watanabe, Katherine Meyer, Tyler Jackson, Tracey Beth Schock Schock, Ed Johnson, Daniel W Bearden
Abstract: Zebra mussel, Dreissena polymorpha, in the Great Lakes is being monitored as a bio-indicator organism for environmental health effects by the National Oceanic and Atmospheric Administration‰s Mussel Watch program. In order to monitor the enviro ...

9. Rbm24a and Rbm24b are required for normal somitogenesis
Topic: Life Sciences Research
Published: 8/29/2014
Author: Samantha D Maragh
Abstract: We recently demonstrated that the gene encoding the RNA binding motif protein 24 (Rbm24)¬¬ is expressed during mouse cardiogenesis, and determined the developmental requirement for its zebrafish homologs Rbm24a and Rbm24b during cardiac developme ...

10. Polyelectrolyte Multilayers in Microfluidic Systems for Biological Applications
Topic: Life Sciences Research
Published: 7/31/2014
Authors: Saugandhika Sarma Minnikanti, Aveek Gangopadhyay, Darwin R Reyes-Hernandez
Abstract: The formation of polyelectrolyte multilayers (PEMs) for the first time two decades ago demonstrating the assembly on charged substrates in a very simple and efficient way have proven to be a reliable method to obtain structures tunable at the nanomet ...

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