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You searched on: Topic Area: Drugs/Pharmaceuticals

Displaying records 1 to 10 of 33 records.
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1. Critical Examination of the Colloidal Particle Model of Globular Proteins
Topic: Drugs/Pharmaceuticals
Published: 2/3/2015
Authors: Prasad Srinivasan Sarangapani, Steven D Hudson, Ronald Leland Jones, Jack F Douglas, Jai Avinash Pathak
Abstract: Recent studies of globular protein solutions have uniformly adopted a colloidal view of proteins as particles, a perspective that neglects the polymeric primary structure of these biological macromolecules, their intrinsic flexibility and their abi ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=915903

2. An interlaboratory comparison of sizing and counting of subvisible particles mimicking protein aggregates
Topic: Drugs/Pharmaceuticals
Published: 11/24/2014
Authors: Dean C Ripple, Christopher B Montgomery, Zhishang Hu
Abstract: Accurate counting and sizing of protein particles has been limited by discrepancies of counts obtained by different methods. To understand the bias and repeatability of techniques in common use in the biopharmaceutical community, the National Institu ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=915231

3. Membrane protein resistance of oligo(ethylene oxide) self-assembled monolayers
Topic: Drugs/Pharmaceuticals
Published: 7/31/2014
Authors: David J Vanderah, Marlon L Walker, David Travis Gallagher, Ryan Vierling, Fay Crawshaw
Abstract: Spectroscopic ellipsometry was used to evaluate the resistance to protein adsorption (RPA) of self- assembled monolayers (SAMs) of HS(CH2)3O(CH2CH2O)6M and [HS(CH2)3CH]2O-(CH2CH2O)6M, where M = CH3 or H, on Au. The SAMs were exposed to fibrinogen ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=913472

4. Microfluidic Remote Loading for Rapid Single-Step Liposomal Drug Preparation
Topic: Drugs/Pharmaceuticals
Published: 7/29/2014
Authors: Wyatt N Vreeland, Renee R Hood, Don L. DeVoe
Abstract: Here we report a microfluidic system that enables rapid and efficient remote loading of amphipathic drugs into nanoscale liposomes, combining liposome synthesis and remote drug loading in a continuous integrated process. Unlike established bulk m ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=915563

5. Microfluidic-Enabled of Liposomes Elucidate Size-Dependent Transdermal Transport
Topic: Drugs/Pharmaceuticals
Published: 3/21/2014
Authors: Wyatt N Vreeland, Renee R Hood, Eric Kendall, Don L. DeVoe, Julia Finkel, Mariana Junqueira, Zenaide Quezado
Abstract: Microfluidic synthesis of small and nearly-monodisperse liposomes is used to investigate the size-dependent passive transdermal transport of nanoscale lipid vesicles. While large liposomes with diameters above 105 nm are found to be excluded from dee ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=915017

6. Facile Smiles-type rearrangement in radical cations of N-acyl arylsulfonamides and analogs
Topic: Drugs/Pharmaceuticals
Published: 1/21/2014
Authors: Karl K Irikura, Nino Guram Todua
Abstract: RATIONALE: N-Alkylation of sulfonylbenzamides was reported recently to cause a dramatic and surprising change in electron ionization mass spectrometry (EIMS), leading to a closed-shell base peak. Only an incomplete, speculative mechanism was availabl ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=912656

7. Microfluidic preparation of liposomes to determine particle size influence on cellular uptake mechanisms
Topic: Drugs/Pharmaceuticals
Published: 10/3/2013
Authors: Wyatt N Vreeland, Abhay U Andar, Renee R Hood, Don L. DeVoe, Peter W Swaan
Abstract: Purpose: This study investigates the cellular uptake and trafficking of liposomes in Caco-2 cells, using vesicles with distinct average diameters ranging from 40 nm-276 nm. Liposomes were prepared by microfluidic hydrodynamic flow focusing, producing ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=913538

8. Effects of Desialylation on Human alpha1-Acid Glycoprotein-Ligand Interactions
Topic: Drugs/Pharmaceuticals
Published: 9/16/2013
Authors: Richard Y. Huang, Jeffrey W Hudgens
Abstract: Human α1-Acid Glycoprotein (AGP), an acute phase glycoprotein, exists predominantly in blood. With its ability to bind basic, lipophilic, and acidic drugs, AGP has served as a drug carrier. It has been shown that the carbohydrate composition of ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=914495

9. Quantitative Analysis of Dendron-Conjugated Cisplatin-Complexed Gold Nanoparticles Using Scanning Particle Mobility Mass Spectrometry
Topic: Drugs/Pharmaceuticals
Published: 5/8/2013
Authors: De-Hao D. Tsai, Tae Joon Cho, Sherrie R. Elzey, Julien C. Gigault, Vincent A Hackley
Abstract: We report a high-resolution and traceable method to quantify the drug loading on nanoparticle-based cancer therapeutics, and demonstrate this method using a model cisplatin functionalized dendron-gold nanoparticle (AuNP) conjugate. Electrospray diffe ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=912782

10. Breast Cancer Biomarker Measurements and Standards
Topic: Drugs/Pharmaceuticals
Published: 1/24/2013
Authors: Kenneth D Cole, Lili Wang, Hua-Jun He
Abstract: Cancer is a heterogeneous disease characterized by changes in the levels and activities of important cellular proteins, including oncogenes and tumor suppressors. Genetic mutations cause changes in protein activity and protein expression levels that ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=912867



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