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Topic Area: Drugs/Pharmaceuticals

Displaying records 1 to 10 of 41 records.
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1. Microfluidic-Enabled of Liposomes Elucidate Size-Dependent Transdermal Transport
Topic: Drugs/Pharmaceuticals
Published: 3/21/2014
Authors: Wyatt N Vreeland, Renee R Hood, Eric Kendall, Don L. DeVoe, Julia Finkel, Mariana Junqueira, Zenaide Quezado
Abstract: Microfluidic synthesis of small and nearly-monodisperse liposomes is used to investigate the size-dependent passive transdermal transport of nanoscale lipid vesicles. While large liposomes with diameters above 105 nm are found to be excluded from dee ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=915017

2. Facile Smiles-type rearrangement in radical cations of N-acyl arylsulfonamides and analogs
Topic: Drugs/Pharmaceuticals
Published: 1/21/2014
Authors: Karl K Irikura, Nino Guram Todua
Abstract: RATIONALE: N-Alkylation of sulfonylbenzamides was reported recently to cause a dramatic and surprising change in electron ionization mass spectrometry (EIMS), leading to a closed-shell base peak. Only an incomplete, speculative mechanism was availabl ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=912656

3. Microfluidic preparation of liposomes to determine particle size influence on cellular uptake mechanisms
Topic: Drugs/Pharmaceuticals
Published: 10/3/2013
Authors: Wyatt N Vreeland, Abhay U Andar, Renee R Hood, Don L. DeVoe, Peter W Swaan
Abstract: Purpose: This study investigates the cellular uptake and trafficking of liposomes in Caco-2 cells, using vesicles with distinct average diameters ranging from 40 nm-276 nm. Liposomes were prepared by microfluidic hydrodynamic flow focusing, producing ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=913538

4. Quantitative Analysis of Dendron-Conjugated Cisplatin-Complexed Gold Nanoparticles Using Scanning Particle Mobility Mass Spectrometry
Topic: Drugs/Pharmaceuticals
Published: 5/8/2013
Authors: De-Hao D. Tsai, Tae Joon Cho, Sherrie R. Elzey, Julien C. Gigault, Vincent A Hackley
Abstract: We report a high-resolution and traceable method to quantify the drug loading on nanoparticle-based cancer therapeutics, and demonstrate this method using a model cisplatin functionalized dendron-gold nanoparticle (AuNP) conjugate. Electrospray diffe ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=912782

5. The Metrology of Counting Protein Particles
Topic: Drugs/Pharmaceuticals
Published: 3/18/2013
Authors: Dean C Ripple, Michael J Carrier, Richard E Cavicchi, Christopher B Montgomery, Zhishang Hu
Abstract: A common degradation pathway for protein-based drugs is the growth of protein aggregates or particles. Counting and characterization of these particles is needed to assure the quality, efficacy, and safety of this type of drug. The unusual physical ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=913322

6. Modification of tethered bilayers by phospholipid exchange with vesicles
Topic: Drugs/Pharmaceuticals
Published: 2/27/2013
Authors: David J Vanderah, Rima Budvytyte, Mindaugas Mickevicius, Gintaras Valincius, Frank Heinrich
Abstract: Phosphatidylcholine and cholesterol exchange between vesicles and planar tethered bilayer lipid membranes (tBLMs) was demonstrated from electrochemical impedance spectroscopy (EIS), fluorescence microscopy (FM), and neutron reflectometry (NR) data. ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=912490

7. Breast Cancer Biomarker Measurements and Standards
Topic: Drugs/Pharmaceuticals
Published: 1/24/2013
Authors: Kenneth D Cole, Lili Wang, Hua-Jun He
Abstract: Cancer is a heterogeneous disease characterized by changes in the levels and activities of important cellular proteins, including oncogenes and tumor suppressors. Genetic mutations cause changes in protein activity and protein expression levels that ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=912867

8. NIST/NIH Vitamin D Metabolites Quality Assurance Program Report of Participant Results: Summer 2011 Exercise (Exercise 4)
Series: NIST Interagency/Internal Report (NISTIR)
Report Number: 7893
Topic: Drugs/Pharmaceuticals
Published: 12/21/2012
Authors: Katrice A Lippa, Mary Bedner, Susan Shu Cheng Tai
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=911154

9. NIST/NIH Vitamin D Metabolites Quality Assurance Program Report of Participant Results:Summer 2010 (Exercise 2)
Series: NIST Interagency/Internal Report (NISTIR)
Report Number: 7891
Topic: Drugs/Pharmaceuticals
Published: 12/21/2012
Authors: Katrice A Lippa, Mary Bedner, Susan Shu Cheng Tai
Abstract: The National Institute of Standards and Technology (NIST) recently established a Vitamin D Metabolites Quality Assurance Program (VitDQAP) in collaboration with the National Institutes of Health (NIH) Office of Dietary Supplements. Participants ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=911153

10. Quantifying Dithiothreitol Displacement of Functional Ligands from Gold Nanoparticles
Topic: Drugs/Pharmaceuticals
Published: 10/27/2012
Authors: De-Hao D. Tsai, Frank W DelRio, Sherrie R. Elzey, Suvajyoti S. Guha, Michael Russel Zachariah, Vincent A Hackley, Melanie P Shelton
Abstract: Dithiothreitol (DTT)-based displacement is widely utilized for separating ligands from their gold nanoparticle (AuNP) conjugates, a critical step for differentiating and quantifying surface-bound functional ligands and therefore the effective surface ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=911354



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