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Topic Area: Nanobiotechnology

Displaying records 1 to 10 of 39 records.
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1. Synapsable quadruplex-mediated fibers
Topic: Nanobiotechnology
Published: 5/3/2013
Authors: Veronika A Szalai, Miguel Angel Mendez
Abstract: We have fabricated and characterized a novel DNA based nanofiber created by synergistic self-assembly of guanine quadruplex (Hoogsteen base pairing) and double-stranded DNA (Watson-Crick base pairing). The assembly of our nanofibers occurs in several ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=907622

2. Theory of Polymer-Nanopore Interactions Refined Using Molecular Dynamics Simulations
Topic: Nanobiotechnology
Published: 4/30/2013
Author: Arvind Kumar Balijepalli
Abstract: Molecular dynamics (MD) simulations were used to refine and extend a theoretical model that describes the interactions of single polyethylene glycol molecules (PEGs) with an α-hemolysin nanopore. A previously developed analytical model assumed ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=913514

3. Surface chemistry and size independently influence the release of model therapeutic nanoparticles from poly(ethylene glycol) hydrogels
Topic: Nanobiotechnology
Published: 4/21/2013
Authors: Stephanie L. Hume, Kavita M Jeerage
Abstract: Nanoparticles have emerged as promising therapeutic and diagnostic tools, due to their unique physicochemical properties. The specific core and surface chemistries, as well as nanoparticle size,all play critical roles in particle transport and inte ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=912443

4. Temperature sculpting in yoctoliter volumes
Topic: Nanobiotechnology
Published: 2/14/2013
Authors: Joseph E Reiner, Joseph William Robertson, Daniel L Burden, Lisa K Burden, Arvind Kumar Balijepalli, John J Kasianowicz
Abstract: The ability to perturb large ensembles of molecules from equilibrium led to major advances in understanding reaction mechanisms in chemistry and biology. Here, we demonstrate the ability to control, measure, and make use of rapid temperature changes ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=910990

5. Disease Detection and Management via Single Nanopore-Based Sensors
Topic: Nanobiotechnology
Published: 12/15/2012
Authors: Joseph E Reiner, Arvind Kumar Balijepalli, Joseph William Robertson, Jason P Campbell, John S Suehle, John J Kasianowicz
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=912356

6. Quantifying Dithiothreitol Displacement of Functional Ligands from Gold Nanoparticles
Topic: Nanobiotechnology
Published: 10/27/2012
Authors: De-Hao Tsai, Frank W DelRio, Sherrie R. Elzey, Suvajyoti S. Guha, Michael Russel Zachariah, Vincent A Hackley, Melanie P Shelton
Abstract: Dithiothreitol (DTT)-based displacement is widely utilized for separating ligands from their gold nanoparticle (AuNP) conjugates, a critical step for differentiating and quantifying surface-bound functional ligands and therefore the effective surface ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=911354

7. Disentangling the effects of polymer coatings on silver nanoparticle agglomeration, dissolution, and toxicity to determine mechanisms of nanotoxicity
Topic: Nanobiotechnology
Published: 9/1/2012
Authors: Justin M Zook, Melissa Danielle Halter, Danielle Cleveland, Stephen E Long
Abstract: Silver nanoparticles (AgNPs) are frequently coated by a variety of polymers, which may affect various intertwined mechanisms of toxicity, including agglomeration and dissolution rate. Here, we measure how citrate, dextran, poly(ethylene glycol) (PEG ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=908497

8. A Lectin-Based Gold Nanoparticle Assay for Probing Glycosylation of Glycoproteins
Topic: Nanobiotechnology
Published: 4/17/2012
Authors: Germarie Sanchez-Pomales, Todd A. Morris, James Falabella, Michael J Tarlov, Rebecca A Zangmeister
Abstract: We report a glycoanalysis method in which lectins are used to probe the glycans of glycoproteins that are adsorbed on gold nanoparticles. A model mannose-presenting glycoprotein, ribonuclease B (RNase B), and the therapeutic monoclonal antibody (mAb) ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=909549

9. Tumor Necrosis Factor Interaction with Gold Nanoparticles
Topic: Nanobiotechnology
Published: 3/14/2012
Authors: De-Hao Tsai, Sherrie R. Elzey, Frank W DelRio, Robert I MacCuspie, Suvajyoti S. Guha, Michael Russel Zachariah, Athena M Keene, Jeffrey D Clogston, Vincent A Hackley
Abstract: We report on a systematic investigation of molecular conjugation of tumor necrosis factor protein-α (TNF) onto gold nanoparticles (AuNPs) and the subsequent binding behavior to its antibody (anti-TNF). We employ a combination of physical and spe ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=909899

10. Through-focus Scanning Optical Microscopy
Topic: Nanobiotechnology
Published: 12/31/2011
Author: Ravikiran Attota
Abstract: Through-focus scanning optical microscopy (TSOM) method provides three-dimensional information (i.e. the size, shape and location) about micro- and nanometer-scale structures. TSOM, based on a conventional optical microscope, achieves this by acquiri ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=908493