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Author: Daniel Bearden
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1. Probing the intracellular glutathione redox potential using in-cell NMR spectroscopy
Steve Y. Rhieu, Aaron A Urbas, Daniel W Bearden, John P Marino, Vytautas Reipa, Katrice A Lippa
Non-invasive and real-time analysis of cellular redox processes has been greatly hampered by lack of suitable measurement techniques. Here we describe an in-cell nuclear magnetic resonance (NMR)-based method for measuring the intracellular glutathion ...
2. Metabolite Profiling of a NIST Standard Reference Material for Human Plasma (SRM 1950) ‹ GC/MS, LC/MS, NMR and Clinical Laboratory Analyses, Libraries and Web-based resources
Yamil Simon, Mark S Lowenthal, Lisa Ervin Kilpatrick, Maureen L Sampson, Kelly H Telu, Paul A Rudnick, William Gary Mallard, Daniel W Bearden, Tracey Beth Schock Schock, Dmitrii V Tchekhovskoi, Niksa Blonder, Xinjian Yan, Yuxue Liang, Yufang Zheng, William E Wallace III, Pedatsur Neta, Karen W Phinney, Alan T. Remaley, Stephen E Stein
Recent progress in metabolomics and the development of increasingly sensitive analytical techniques have renewed interest in global profiling, i.e., semi-quantitative monitoring of all chemical constituents of biological fluids. In this work, we have ...
3. Evaluation of Pacific White Shrimp (Litopenaeus vannamei) Health During a Superintensive Aquaculture Growout using NMR-based Metabolomics
Tracey Beth Schock Schock, Daniel W Bearden, Jessica Duke, Abby Goodson, Daryl Weldon, Jeff Brunson, John Leffler
Success of the shrimp aquaculture industry requires technological advances that increase production and environmental sustainability. Indoor, superintensive, aquaculture systems have been developed that permit year-round production of farmed shrimp a ...
4. Metallofullerene with a Distorted Shape: Structural Investigation of Y3N@C78
Daniel W Bearden, Jianyuan Zhang, Fuhrer Tim, Wujun Fu, Tianming Zuo, Liaosa Xu, Harry C. Dorn
In recent decades, the trimetallic nitride template endohedral metallofullerenes (TNT-EMFs),1 which consist of a trimetallic nitride
cluster and a fullerene cage, have attracted extensive research interest due to their unique structural character ...
5. Biosynthesis of Athmu, a alpha,gamma-hydroxy-ß-amino acid of pahayokolides A-B
Li Liu, Daniel W Bearden, Juan C. Rodriguez, Kathleen S. Rein
Pahayokolides A-B are cyanobacteria derived non-ribosomal peptides which exhibit cytotoxicity against a number of cancer cell
lines. The biosynthetic origin of the 3-amino-2,5,7,8- tetrahydroxy-10-methylundecanoic acid (Athmu) moiety has been
6. Identification of Isethionic Acid and Other Small Molecule Metabolites of Fragilariopsis cylindrus with Nuclear Magnetic Resonance
Daniel W Bearden, Arezue F. B. Boroujerdi, Peter A. Lee, Giacomo R. DiTullio, Michael G. Janech, Sarah B. Vied
Nuclear magnetic resonance (NMR)-spectroscopy has been used to obtain metabolic profiles of the polar diatom Fragilariopsis
cylindrus, leading to the identification of a novel metabolite in this organism. Initial results from an ongoing metabolomic ...
7. Nanoscale Fullerene Compression of an Yttrium Carbide Cluster
Jianyuan Zhang, Fuhrer Tim, Wujun Fu, Jiechao Ge, Daniel W Bearden, Jerry Dallas, Duchamp James, Kenneth Walker, Hunter Champion, Hugo Azurmendi, Kim Harich, Harry C. Dorn
The encapsulation of clusters (or small molecules) in spheroidal fullerene cages provides a unique isolated environment that is
important in describing their shape, dynamics, and physical properties. For the case of yttrium carbide clusters, we fin ...
8. Environmental Metabolomics
Daniel W Bearden
The application of metabolomics in the field of environmental science or ecology, which has developed based substantially on
NMR spectroscopic approaches, is a fast paced, rapidly developing field which seems to be poised to help re-frame the discu ...
9. An NMR-based Metabolomic Assessment of Cultured Cobia Health in Response to Dietary Manipulation
Tracey Beth Schock Schock, Sarah Newton, Karl Brenkert, John Leffler, Daniel W Bearden
Aquaculture produces a significant source of protein for global human consumption. Commercial fish diets rely heavily on
fishmeal and fish oil, which can be costly. Alternative protein and lipid sources may provide nutritionally improved high
10. NMR Analysis of Metabolic Responses to Extreme Growing Conditions of the Temperature-Dependent Coral Pathogen Vibrio
Arezue Boroujerdi, Stephen S. Jones, Daniel W Bearden
Recent metabolomics research on the temperature-dependent coral pathogen Vibrio coralliilyticus has led to the discovery of
several compounds produced by the organism as a response to high-density, low nutrient growing conditions. Three compounds ...