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Author: M Miral Dizdar

Displaying records 1 to 10 of 65 records.
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1. Significant disparity in base and sugar damage in DNA by neutron and electron irradiation
Published: 7/1/2014
Authors: Pawel Jaruga, Jeffrey S Nico, Lisa R Karam, Olga Timofeeva, William Blakely, M Miral Dizdar, D Pang
Abstract: In this study a comparison of the effects of high-LET neutrons with low-LET electrons on irradiation of aqueous DNA solutions was investigated to characterize for potential neutron signatures on DNA damage induction. Ionizing radiations generate ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=915234

2. Quantitative Assessment of Nanoparticle Induced Oxidative Damage to DNA Using Isotope Dilution Mass Spectrometry
Published: 6/16/2014
Authors: Elijah J Petersen, Pawel Jaruga, M Miral Dizdar, Bryant C Nelson
Abstract: Mass spectrometry techniques have been employed as one of the primary analytical tools for investigating the effects of oxygen-derived free radicals on the induction and subsequent repair of oxidatively-induced DNA damage in living systems. The Natio ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=915778

3. Clemens von Sonntag and the early history of radiation-induced sugar damage in DNA
Published: 6/2/2014
Author: M Miral Dizdar
Abstract: This article reviews the early history of radiation-induced sugar damage in DNA in dedication to Prof. Clemens von Sonntag, who recently passed away. It covers the ten years between 1968 and 1978, during which most of the work on the ionizing radiati ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=915276

4. Inhibition of DNA glycosylases via small molecule purine analogs
Published: 12/9/2013
Authors: M Miral Dizdar, Aaron C. Jacobs, Ajit Jadhav, Dorjbal Dorjsuren, David Maloney, Anton Simeonov, Pawel Jaruga, Amanda K. McCullough, R. Stephen Lloyd
Abstract: Following the formation of oxidatively-induced DNA damage, several DNA glycosylases are required to initiate repair of the base lesions that are formed. Recently, NEIL1 and other DNA glycosylases, including OGG1 and NTH1 were identified as potent ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=914071

5. Identification and Quantification of DNA Repair Protein Apurinic/Apyrimidinic Endonuclease 1 (APE1) in Human Cells by Liquid Chromatography/Isotope-Dilution Tandem Mass Spectrometry
Published: 7/29/2013
Authors: Guldal Kirkali, Pawel Jaruga, Prasad T Reddy, Alessandro Tona, Li Mengxia, David M. Wison III, M Miral Dizdar, Bryant C Nelson
Abstract: Unless repaired, DNA damage can drive mutagenesis or cell death. DNA repair proteins may therefore be used as biomarkers in disease detection or therapeutic response estimation. Thus, the accurate measurement of DNA repair protein expression is of fu ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=913457

6. Oxidatively Induced Damage to DNA: Potential Role of Single-Wall Carbon Nanotubes at the Molecular Level
Published: 5/13/2013
Authors: Elijah J Petersen, Xiaomin X. Tu, M Miral Dizdar, Ming Zheng, Bryant C Nelson
Abstract: Ultrasonication is a physical process known to generate abundant levels of oxygen-derived species such as hydroxyl radicals, hydrogen atoms, and hydrogen peroxide. When used to process DNA solutions, these highly reactive hydroxyl radicals can react ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=913561

7. Tools and Approaches for the Assessment of Nanomaterial Induced Oxidative DNA Damage
Published: 5/13/2013
Authors: Elijah J Petersen, Bryce Marquis, Pawel Jaruga, M Miral Dizdar, Bryant C Nelson
Abstract: Hyphenated mass spectrometry techniques have been employed as one of the primary analytical tools for investigating the effects of ionizing radiation, chemical/biological carcinogens, and oxygen derived free radicals on the induction and subsequent r ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=913562

8. Oxidatively Induced DNA Damage and Cancer
Published: 12/31/2012
Author: M Miral Dizdar
Abstract: Endogenous and exogenous sources cause oxidatively induced DNA damage in living organisms by a variety of mechanisms. Resulting DNA lesions are mutagenic and, unless repaired, lead to a variety of mutations and consequently to genetic instability, wh ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=909458

9. Identification and Quantification of Human DNA Repair Protein NEIL1 by Liquid Chromatography/Isotope-Dilution Tandem Mass Spectrometry
Published: 12/26/2012
Authors: M Miral Dizdar, Pawel Jaruga, Guldal Kirkali, Bryant C Nelson, Gamze Tuna, Prasad T Reddy
Abstract: Accumulated evidence points to DNA repair capacity as an important factor in cancer and other diseases. DNA repair proteins are promising drug targets and are emerging as prognostic and therapeutic biomarkers. Thus, the knowledge of the overexpressio ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=913458

10. Protective roles of single-wall carbon nanotubes in ultrasonication-induced DNA base damage
Published: 8/27/2012
Authors: Elijah J Petersen, Xiaomin X. Tu, M Miral Dizdar, Ming Zheng, Bryant C Nelson
Abstract: Ultrasonication is a physical process known to generate abundant levels of oxygen-derived species such as hydroxyl radicals, hydrogen atoms, and hydrogen peroxide. Highly reactive hydroxyl radicals can react with DNA to generate strand breaks and a m ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=911310



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