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You searched on: Author: M Miral Dizdar

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1. Measurement of oxidatively induced DNA damage and its repair by mas spectrometric techniques
Published: 3/25/2015
Authors: M Miral Dizdar, Erdem Coskun, Pawel Jaruga
Abstract: Oxidatively induced damage caused by free radicals and other DNA-damaging agents generate a plethora of products in DNA of living organisms. There is mounting evidence for the involvement of this type of damage in the etiology of numerous diseases in ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=917824

2. Bisphenol A leads to oxidative DNA damage and alters the damage response in mouse fibroblasts
Published: 2/18/2015
Authors: Pawel Jaruga, Natalie R Gassman, Erdem Coskun, Donna F Stefanick, Julie K Horton, M Miral Dizdar, Samuel H Wilson
Abstract: Metabolism of bisphenol A (BPA) generates reactive oxygen species causing DNA strand breaks and damaged DNA bases. Base excision repair (BER) is responsible for removing oxidatively induced DNA base lesions and for repairing single strand breaks (SSB ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=916441

3. Oxidatively Induced DNA Damage and Its Repair in Cancer
Published: 2/2/2015
Author: M Miral Dizdar
Abstract: Oxidatively induced DNA damage is caused in living organisms by endogenous and exogenous reactive species. DNA lesions resulting from this type of damage are mutagenic and cytotoxic and, if not repaired, can cause genetic instability that may lead to ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=917052

4. Significant disparity in base and sugar damage in DNA by neutron and electron irradiation
Published: 7/1/2014
Authors: Pawel Jaruga, Jeffrey S Nico, Lisa R Karam, Olga Timofeeva, William Blakely, M Miral Dizdar, D Pang
Abstract: In this study a comparison of the effects of high-LET neutrons with low-LET electrons on irradiation of aqueous DNA solutions was investigated to characterize for potential neutron signatures on DNA damage induction. Ionizing radiations generate ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=915234

5. Quantitative Assessment of Nanoparticle Induced Oxidative Damage to DNA Using Isotope Dilution Mass Spectrometry
Published: 6/16/2014
Authors: Elijah J Petersen, Pawel Jaruga, M Miral Dizdar, Bryant C Nelson
Abstract: Mass spectrometry techniques have been employed as one of the primary analytical tools for investigating the effects of oxygen-derived free radicals on the induction and subsequent repair of oxidatively-induced DNA damage in living systems. The Natio ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=915778

6. Clemens von Sonntag and the early history of radiation-induced sugar damage in DNA
Published: 6/2/2014
Author: M Miral Dizdar
Abstract: This article reviews the early history of radiation-induced sugar damage in DNA in dedication to Prof. Clemens von Sonntag, who recently passed away. It covers the ten years between 1968 and 1978, during which most of the work on the ionizing radiati ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=915276

7. Inhibition of DNA glycosylases via small molecule purine analogs
Published: 12/9/2013
Authors: M Miral Dizdar, Aaron C. Jacobs, Ajit Jadhav, Dorjbal Dorjsuren, David Maloney, Anton Simeonov, Pawel Jaruga, Amanda K. McCullough, R. Stephen Lloyd
Abstract: Following the formation of oxidatively-induced DNA damage, several DNA glycosylases are required to initiate repair of the base lesions that are formed. Recently, NEIL1 and other DNA glycosylases, including OGG1 and NTH1 were identified as potent ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=914071

8. Identification and Quantification of DNA Repair Protein Apurinic/Apyrimidinic Endonuclease 1 (APE1) in Human Cells by Liquid Chromatography/Isotope-Dilution Tandem Mass Spectrometry
Published: 7/29/2013
Authors: Guldal Kirkali, Pawel Jaruga, Prasad T Reddy, Alessandro Tona, Li Mengxia, David M. Wison III, M Miral Dizdar, Bryant C Nelson
Abstract: Unless repaired, DNA damage can drive mutagenesis or cell death. DNA repair proteins may therefore be used as biomarkers in disease detection or therapeutic response estimation. Thus, the accurate measurement of DNA repair protein expression is of fu ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=913457

9. Oxidatively Induced Damage to DNA: Potential Role of Single-Wall Carbon Nanotubes at the Molecular Level
Published: 5/13/2013
Authors: Elijah J Petersen, Xiaomin X. Tu, M Miral Dizdar, Ming Zheng, Bryant C Nelson
Abstract: Ultrasonication is a physical process known to generate abundant levels of oxygen-derived species such as hydroxyl radicals, hydrogen atoms, and hydrogen peroxide. When used to process DNA solutions, these highly reactive hydroxyl radicals can react ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=913561

10. Tools and Approaches for the Assessment of Nanomaterial Induced Oxidative DNA Damage
Published: 5/13/2013
Authors: Elijah J Petersen, Bryce Marquis, Pawel Jaruga, M Miral Dizdar, Bryant C Nelson
Abstract: Hyphenated mass spectrometry techniques have been employed as one of the primary analytical tools for investigating the effects of ionizing radiation, chemical/biological carcinogens, and oxygen derived free radicals on the induction and subsequent r ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=913562



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