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Author: Karen Phinney
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1. Quantitative bottom-up proteomics depends on digestion conditions
Mark S Lowenthal, Yuxue Liang, Karen W Phinney, Stephen E Stein
Accurate quantification is a fundamental requirement in the fields of proteomics and biomarker discovery, and for clinical diagnostic assays. To demonstrate the extent of quantitative variability in measurable peptide concentrations due to differenc ...
2. Development of a Standard Reference Material for Metabolomics Research
Karen W Phinney, Guillaume Ballihaut, Mary Bedner, Johanna Camara, Steven J Christopher, William C Davis, Nathan G. Dodder, Brian E Lang, Stephen E Long, Mark S Lowenthal, Elizabeth A. McGaw, Karen E Murphy, Bryant C Nelson, Jocelyn L. Prendergast, Jessica L Reiner, Catherine A Rimmer, Lane C Sander, Michele M Schantz, Katherine E Sharpless, Lorna Tregoning Sniegoski, Susan Shu Cheng Tai, Jeanice M Brown Thomas, Thomas W Vetter, Michael James Welch, Stephen A Wise, Laura J Wood, William F Guthrie, Robert Charles Hagwood, Stefan D Leigh, James H Yen, Nien F Zhang, Madhu Chaurhary-Webb, Huiping Chen, Bridgette Haynes, Donna J LaVoie, Leslie F McCoy, Shahzad S Momin, Neelima Paladugula, Elizabeth C Pendergrast, Christine M Pfeiffer, Carissa D Powers, Zia Fazili-Qari, Daniel Rabinowitz, Michael E Rybak, Rosemary L Schleicher, Mary Xu, Mindy Zhang, Arthur L Castle, Brandi S Benford, Gauthier Eppe
3. Metabolite Profiling of a NIST Standard Reference Material for Human Plasma (SRM 1950) ‹ GC/MS, LC/MS, NMR and Clinical Laboratory Analyses, Libraries and Web-based resources
Yamil Simon, Mark S Lowenthal, Lisa Ervin Kilpatrick, Maureen L Sampson, Kelly H Telu, Paul A Rudnick, William Gary Mallard, Daniel W Bearden, Tracey Beth Schock Schock, Dmitrii V Tchekhovskoi, Niksa Blonder, Xinjian Yan, Yuxue Liang, Yufang Zheng, William E Wallace III, Pedatsur Neta, Karen W Phinney, Alan T. Remaley, Stephen E Stein
Recent progress in metabolomics and the development of increasingly sensitive analytical techniques have renewed interest in global profiling, i.e., semi-quantitative monitoring of all chemical constituents of biological fluids. In this work, we have ...
4. Quantification of transferrin in human serum using both QconCAT and synthetic internal standards
Tyler A. (Tyler) Zimmerman, Meiyao M. Wang, Mark S Lowenthal, Illarion V Turko, Karen W Phinney
Transferrin, an iron transport protein, is a clinically-important biomarker in diseases such as
iron-deficiency anemia. Current diagnostic methods for transferrin levels lack quantitative
accuracy, suggesting the need for alternative approaches ...
5. The Development and Implementation of Quality Assurance Programs to Support Nutritional Measurements
Lane C Sander, Mary Bedner, David Lee Duewer, Katrice A Lippa, Melissa Meaney Phillips, Karen W Phinney, Catherine A Rimmer, Michele M Schantz, Katherine E Sharpless, Susan Shu Cheng Tai, Jeanice M Brown Thomas, Stephen A Wise, Laura J Wood, J. M. Betz, Paul M Coates
The National Institute of Standards and Technology administers quality assurance programs devoted to improving measurements of nutrients and related metabolites in foods, dietary supplements, and serum and plasma samples. These programs have been de ...
6. Universal Proteolysis and MSn for N- and O- Glycan Branching Analysis
John E Schiel, Karen W Phinney, Nicholas J Smith
The continually growing list of critical glycosylation-related processes has made analytical methodology for detailed glycan characterization an area of increasing interest. Glycosylation is a post translational modification of unsurpassed comple ...
7. Determination of fortified and endogenous folates in food-based Standard Reference Materials by liquid chromatography-tandem mass spectrometry
Johanna Camara, Mark S Lowenthal, Karen W Phinney
The National Institute of Standards and Technology (NIST) is developing a wide variety of Standard Reference Materials (SRMs) to support measurements of vitamins and other nutrients in foods. Previously, NIST has provided SRMs with values assigned f ...
8. Characterizing Vaccinium berry Standard Reference Materials using NIST Mass Spectral Libraries
Mark S Lowenthal, Nirina Rabe Andriamaharavo, Stephen E Stein, Karen W Phinney
A gas chromatography-mass spectrometry-based (GC-MS) method was developed for qualitative
characterization of metabolites found in Vaccinium-fruit (berry) dietary supplement Standard
Reference Materials (SRMs). Definitive identifications are pro ...
9. Quantifying CD4 Receptor Density on Human T Lymphocytes Using Multiple Reaction Monitoring Mass Spectrometry
Meiyao M. Wang, Hua-Jun He, Illarion V Turko, Karen W Phinney, Lili Wang
CD4 is an important glycoprotein containing a transmembrane portion and a short intracellular tail. It locates on the surface of various types of immune cells and performs critical role in multiple cellular functions such as signal amplification and ...
10. Developing qualitative LC-MS methods for characterization of Vaccinium berry Standard Reference Materials
Mark S Lowenthal, Melissa Meaney Phillips, Catherine A Rimmer, Paul A Rudnick, Yamil Simon, Stephen E Stein, Karen W Phinney