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Author: Karen Phinney

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1. Analysis of Deamidation Artifacts Induced by Microwave-Assisted Tryptic Digestion of a Monoclonal Antibody
Published: 7/31/2014
Authors: Catherine A Formolo, Nathanael A Heckert, Karen W Phinney
Abstract: The thorough characterization of biopharmaceuticals is essential for ensuring their quality and safety, since many potential variations can cause changes to a drug‰s properties that may be detrimental to the patient. Prior to approval and release, p ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=914894

2. Multiplexed LC-MS/MS Assay for Urine Albumin
Published: 7/24/2014
Authors: Ashley Beasley Green, David M Bunk, Karen W Phinney
Abstract: Targeted Multiplexed Assay for Urinary Albumin Quantification Ashley Beasley-Green, Nijah M. Burris, David Bunk, Karen Phinney Biomolecular Measurement Division National Institute of Standards and Technology, Gaithersburg, MD ABSTRACT Uri ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=915346

3. Quantitative bottom-up proteomics depends on digestion conditions
Published: 12/2/2013
Authors: Mark S Lowenthal, Yuxue Liang, Karen W Phinney, Stephen E Stein
Abstract: Accurate quantification is a fundamental requirement in the fields of proteomics and biomarker discovery, and for clinical diagnostic assays. To demonstrate the extent of quantitative variability in measurable peptide concentrations due to differenc ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=914393

4. Development of a Standard Reference Material for Metabolomics Research
Published: 11/4/2013
Authors: Karen W Phinney, Guillaume Ballihaut, Mary Bedner, Johanna Camara, Steven J Christopher, William C Davis, Nathan G. Dodder, Brian E Lang, Stephen E Long, Mark S Lowenthal, Elizabeth A. McGaw, Karen E Murphy, Bryant C Nelson, Jocelyn L. Prendergast, Jessica L Reiner, Catherine A Rimmer, Lane C Sander, Michele M Schantz, Katherine E Sharpless, Lorna Tregoning Sniegoski, Susan Shu Cheng Tai, Jeanice M Brown Thomas, Thomas W Vetter, Michael James Welch, Stephen A Wise, Laura J Wood, William F Guthrie, Robert Charles Hagwood, Stefan D Leigh, James H Yen, Nien F Zhang, Madhu Chaurhary-Webb, Huiping Chen, Bridgette Haynes, Donna J LaVoie, Leslie F McCoy, Shahzad S Momin, Neelima Paladugula, Elizabeth C Pendergrast, Christine M Pfeiffer, Carissa D Powers, Zia Fazili-Qari, Daniel Rabinowitz, Michael E Rybak, Rosemary L Schleicher, Mary Xu, Mindy Zhang, Arthur L Castle, Brandi S Benford, Gauthier Eppe
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=912559

5. Metabolite Profiling of a NIST Standard Reference Material for Human Plasma (SRM 1950) ‹ GC/MS, LC/MS, NMR and Clinical Laboratory Analyses, Libraries and Web-based resources
Published: 10/22/2013
Authors: Yamil Simon, Mark S Lowenthal, Lisa Ervin Kilpatrick, Maureen L Sampson, Kelly H Telu, Paul A Rudnick, William Gary Mallard, Daniel W Bearden, Tracey Beth Schock Schock, Dmitrii V Tchekhovskoi, Niksa Blonder, Xinjian Yan, Yuxue Liang, Yufang Zheng, William E Wallace III, Pedatsur Neta, Karen W Phinney, Alan T. Remaley, Stephen E Stein
Abstract: Recent progress in metabolomics and the development of increasingly sensitive analytical techniques have renewed interest in global profiling, i.e., semi-quantitative monitoring of all chemical constituents of biological fluids. In this work, we have ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=913835

6. Quantification of transferrin in human serum using both QconCAT and synthetic internal standards
Published: 9/27/2013
Authors: Tyler A. (Tyler) Zimmerman, Meiyao M. Wang, Mark S Lowenthal, Illarion V Turko, Karen W Phinney
Abstract: Transferrin, an iron transport protein, is a clinically-important biomarker in diseases such as iron-deficiency anemia. Current diagnostic methods for transferrin levels lack quantitative accuracy, suggesting the need for alternative approaches ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=914041

7. Evaluation of Vitamin D Standardization Program protocols for standardizing serum 25-hydroxyvitamin D data: a case study of the program's potential for national nutrition and health surveys
Published: 6/3/2013
Authors: Karen W Phinney, Kevin Cashman, Mairead Kiely, Michael Kinsella, Ramon Durazo-Arvizu, Lu Tian, Yue Zhang, Alice Lucey, Albert Flynn, Michael Gibney, Mary Frances Picciano, Christopher T. Sempos
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=915282

8. The Development and Implementation of Quality Assurance Programs to Support Nutritional Measurements
Published: 5/24/2013
Authors: Lane C Sander, Mary Bedner, David Lee Duewer, Katrice A Lippa, Melissa Meaney Phillips, Karen W Phinney, Catherine A Rimmer, Michele M Schantz, Katherine E Sharpless, Susan Shu Cheng Tai, Jeanice M Brown Thomas, Stephen A Wise, Laura J Wood, J. M. Betz, Paul M Coates
Abstract: The National Institute of Standards and Technology administers quality assurance programs devoted to improving measurements of nutrients and related metabolites in foods, dietary supplements, and serum and plasma samples. These programs have been de ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=912409

9. Universal Proteolysis and MSn for N- and O- Glycan Branching Analysis
Published: 4/20/2013
Authors: John E Schiel, Karen W Phinney, Nicholas J Smith
Abstract: The continually growing list of critical glycosylation-related processes has made analytical methodology for detailed glycan characterization an area of increasing interest. Glycosylation is a post translational modification of unsurpassed comple ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=912398

10. Determination of fortified and endogenous folates in food-based Standard Reference Materials by liquid chromatography-tandem mass spectrometry
Published: 1/26/2013
Authors: Johanna Camara, Mark S Lowenthal, Karen W Phinney
Abstract: The National Institute of Standards and Technology (NIST) is developing a wide variety of Standard Reference Materials (SRMs) to support measurements of vitamins and other nutrients in foods. Previously, NIST has provided SRMs with values assigned f ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=912489



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