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You searched on: Author: timothy quinn

Displaying records 11 to 20 of 28 records.
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11. Pulsed high intensity focused ultrasound mediated delivery: Mechanisms and efficacy in murine muscle
Published: 2/1/2009
Authors: B. O'Neill, Howard Vo, Mary Angstadt, Timothy P Quinn, Victor Frenkel
Abstract: High intensity focused ultrasound (HIFU) is generally thought to interact with biological tissues in two ways: hyperthermia (heat) and acoustic cavitation. Pulsed mode HIFU has recently been demonstrated to increase the efficacy of a variety of drug ...

12. Stiffening of the Extrapulmonary Arteries in Chronic Hypoxic Pulmonary Hypertension
Published: 7/1/2008
Authors: Elizabeth S Drexler, J. E. Bischoff, Christopher N McCowan, Andrew J Slifka, Timothy P Quinn, Robin Shandas, Dunbar Ivy, K. R. Stenmark
Abstract: It is increasingly appreciated that changes in the compliance properties of large blood vessels are critical determinants of ventricular afterload and ultimately dysfunction. Little is known of the mechanical properties of large vessels in the settin ...

13. Investigations into the potential contribution of a thermal mechanism for pulsed-high intensity focused ultrasound mediated delivery
Published: 12/3/2007
Authors: Brian E. O'Neill, Howard Vo, Mary Angstadt, Victor Frenkel, Bradford Wood, Timothy P Quinn
Abstract: The mechanism behind pulsed high intensity focused ultrasound (pHIFU) effects leading to increased drug delivery are currently poorly understood. In this work, the thermal dose and peak temperatures associated with a typical pHIFU treatment were meas ...

Published: 7/2/2007
Authors: Timothy P Quinn, Tammy L. Oreskovic, Forrest Andrew Landis, N. R. Washburn
Abstract: We investigate material models for a polymeric scaffold used for bone. The material was made by co-extruding poly(¿¿-caprolactone) (PCL), a biodegradable polyester, and poly(ethylene oxide) (PEO). The water soluble PEO was removed resulting in a poro ...

Published: 6/29/2007
Authors: Brian E. O'Neill, Timothy P Quinn, Victor Frenkel, King C. Li
Abstract: A biphasic model of soft tissue has been combined with a simple confined compression test to measure the hydraulic conductivity of soft tissues. The biphasic model treated the tissue as a mixture of an incompressible fluid and porous elastic solid. ...

16. A Multi-Phasic Continuum Damage Mechanics Model of Mechanically Induced Increased Permeability in Tissues
Published: 12/30/2005
Authors: Brian O'Neill, Timothy P Quinn, Victor F. Frankel, King C. Li
Abstract: Recently, we have reported enhanced permeability of tissues due to in vivo treatment with pulsed high intensity focused ultrasound (pHIFU). This new therapy has shown promise as a way of increasing the penetration of large drug molecules both out of ...

17. Dynamic Factors Contributing to Buckling and Birdnesting During GMAW Wire Feeding
Published: 6/1/2005
Authors: Toby Padilla, Timothy P Quinn, D. R. Munoz, R. A. Rorrer, John R. Berger
Abstract: This study provides experimental data for determining the factors affecting wire feeding performance. Full-scale experiments show that feeding performance, in terms of wire feed speed and wire feeding force, varies with the material system and with t ...

18. A Coupled Arc and Droplet Model of GMAW
Published: 1/8/2005
Authors: Timothy P Quinn, M Szanto, T Gilad, I Shai
Abstract: A model of gas metal arc welding was developed that solves the magneto-hydrodynamic equations for the flow and temperature fields of the molten electrode and the plasma simultaneously, to form a fully coupled model. A commercial finite element code ...

19. Constitutive Models for a Poly(e-caprolactone) Scaffold
Published: 10/1/2004
Authors: Timothy P Quinn, Tammy L. Oreskovic, Christopher N McCowan, N Washburn
Abstract: We investigate material models for a porous, polymeric scaffold used for bone. The material was made by co-extruding poly (e-caprolactone) (PCL), a biodegradable polyester, and poly(ethylene oxide)(PEO). The water soluble PEO was removed resulting in ...

20. A Mathematical Model of Wire Feeding Mechanisms in GMAW
Published: 7/1/2003
Authors: T M Padilla, D. R. Munoz, Timothy P Quinn, R. A. Rorrer
Abstract: A Hertzian based contact model of the friction between the welding wire and the wire liner has been developed to predict the wire pulling force for gas metal arc welding (GMAW). The model predicts a 2.5:1exponential increase in wire pulling force as ...

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