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You searched on: Author: pawel jaruga Sorted by: date

Displaying records 1 to 10 of 72 records.
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1. GC-MS/MS Measurement of Nanomaterial Induced Genotoxicity in Isolated DNA
Series: Special Publication (NIST SP)
Report Number: 1200-19
Published: 11/24/2015
Authors: Bryant C Nelson, Elijah J Petersen, Pawel Jaruga, M Miral Dizdar
Abstract: Making accurate measurements of the environmental fate and environmental and biological effects of engineered nanomaterials (ENMs) is critical for reliable risk assessment of these materials. ENM induced oxidative stress and/or direct binding of ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=919143

2. GC/MS Measurement of Nanomaterial Induced Genotoxicity in Isolated DNA
Series: Special Publication (NIST SP)
Report Number: 1200-18
Published: 11/24/2015
Authors: Bryant C Nelson, Elijah J Petersen, Pawel Jaruga, M Miral Dizdar
Abstract: Making accurate measurements of the environmental fate and environmental and biological effects of engineered nanomaterials (ENMs) is critical for reliable risk assessment of these materials. ENM induced oxidative stress and/or direct binding of ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=919142

3. LC-MS/MS Measurement of Nanomaterial Induced Genotoxicity in Isolated DNA
Series: Special Publication (NIST SP)
Report Number: 1200-20
Published: 11/24/2015
Authors: Bryant C Nelson, Elijah J Petersen, Pawel Jaruga, M Miral Dizdar
Abstract: Making accurate measurements of the environmental fate and environmental and biological effects of engineered nanomaterials (ENMs) is critical for reliable risk assessment of these materials. However, the unique behaviors of ENMs may cause artifa ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=919144

4. Extreme expression of DNA repair protein apurinic/apyrimi-dinic endonuclease I (APE1) in human breast cancer as measured by liquid-chromatography isotope-dilution tandem mass spectrometry
Published: 9/15/2015
Authors: Erdem Coskun, Pawel Jaruga, Prasad T Reddy, M Miral Dizdar
Abstract: Apurinic/apyrimidinic endonuclease 1 (APE1) is a DNA re-pair protein and plays other important roles. Increased lev-els of APE1 in cancer have been reported. However, avail-able methods to measure APE1 levels are indirect and not quantitative. We pre ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=919226

5. Measurement of oxidatively modified DNA bases and nucleosides by isotope-dilution mass spectrometry
Published: 9/1/2015
Author: Pawel Jaruga
Abstract: Among cellular structures, the genome is particularly prone to damage, which can result from spontaneous reactions, replication linked failures, or oxidative processes due to metabolic derivatives or to external agents. Damage to DNA causes more sev ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=918872

6. Small Molecule Inhibitors of 8-Oxoguanine DNA Glycosylase-1 (OGG1)
Published: 8/7/2015
Authors: Pawel Jaruga, Erdem Coskun, M Miral Dizdar, Nathan Donley, Stephen Lloyd, Amanda McCullough
Abstract: ABSTRACT The DNA base excision repair (BER) pathway, which utilizes DNA glycosylases to initiate repair of specific DNA lesions, is the major pathway for the repair of DNA damage induced by oxidation, alkylation, and deamination. Early results from ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=918829

7. Production, Purification and Characterization of 15N-Labeled DNA Repair Proteins as Internal Standards for Mass Spectrometric Measurements
Published: 7/26/2015
Authors: Prasad T Reddy, Pawel Jaruga, Bryant C Nelson, Mark S Lowenthal, Ann-Sofie Jemth, Olga Loseva, Erdem Coskun, Thomas Helleday, M Miral Dizdar
Abstract: Oxidatively induced DNA damage is caused in living organisms by a variety of damaging agents, resulting in the formation of a multiplicity of lesions, which are mutagenic and cytotoxic. Unless repaired by DNA repair mechanisms before DNA replication, ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=918645

8. Addiction to MTH1 protein results in intense expression in human breast cancer tissue as measured by liquid chromatography-isotope-dilution tandem mass spectrometry
Published: 6/23/2015
Authors: Erdem Coskun, Pawel Jaruga, Ann-Sofie Jemth, Olga Loseva, Leona Dance Scanlan, Alessandro Tona, Mark S Lowenthal, Thomas Helleday, M Miral Dizdar
Abstract: MTH1 protein sanitizes the nucleotide pool so that modified 2'-deoxynucleoside triphosphates (dNTPs) cannot be used in DNA replication. Cancer cells require MTH1 to avoid incorporation of modified dNTPs resulting in DNA damage mutations and cell ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=918110

9. Measurement of oxidatively induced DNA damage and its repair by mas spectrometric techniques
Published: 3/25/2015
Authors: M Miral Dizdar, Erdem Coskun, Pawel Jaruga
Abstract: Oxidatively induced damage caused by free radicals and other DNA-damaging agents generate a plethora of products in DNA of living organisms. There is mounting evidence for the involvement of this type of damage in the etiology of numerous diseases in ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=917824

10. Bisphenol A leads to oxidative DNA damage and alters the damage response in mouse fibroblasts
Published: 2/18/2015
Authors: Pawel Jaruga, Natalie R Gassman, Erdem Coskun, Donna F Stefanick, Julie K Horton, M Miral Dizdar, Samuel H Wilson
Abstract: Metabolism of bisphenol A (BPA) generates reactive oxygen species causing DNA strand breaks and damaged DNA bases. Base excision repair (BER) is responsible for removing oxidatively induced DNA base lesions and for repairing single strand breaks (SSB ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=916441



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