Take a sneak peek at the new NIST.gov and let us know what you think!
(Please note: some content may not be complete on the beta site.).
Bioimaging—A 21st-Century Toolbox for Medical Technology (+$4 million)
From X-ray and ultrasound images to cutting-edge 3D and 4D body images using CT scans, MRI, PET, or other advanced technologies, bioimaging is a powerful tool for viewing the internal workings of the body and its diseases.
Despite great strides in bioimaging, the field falls far short of its potential. Clinicians want to be able to treat these pictures quantitatively—to say, for example, by how much a tumor grew or shrank in response to treatment. About 40 percent of clinical trials use imaging this way.
But there is no strong measurement foundation to make those assessments accurate, reliable, and repeatable. In drug discovery, such “quantitative” imaging may be distributed among numerous test centers—and sometimes as much as 50 percent of the clinical data is useless because valid comparisons can’t be made between two sites due to the lack of adequate standards.
For similar reasons, bioimaging technology usually is incapable of diagnosis—distinguishing between aggressive and benign tumors, for example. Advances in bioimaging will turn pictures into reliable data that can be used by medical professionals for diagnosis and analysis, reducing the need for biopsies and other invasive procedures and improving early detection and treatment of cancers, targeted drug therapies, and the monitoring of joint, valve, and organ replacements.
Proposed NIST Program
Many of the current roadblocks in moving from simple observation to quantitative diagnosis are issues of measurement and standards. Such a complex field requires a broad, interdisciplinary approach, marrying the physical, chemical, biological, and information sciences. NIST has strengths in all those areas and a long tradition in multidisciplinary research. NIST will partner its expertise in the physical and information sciences with the experience and know-how of the National Institutes of Health (NIH) and the bioimaging industry to develop the needed measurement capabilities.
The initiative focuses on three key areas:
The initiative is expected to advance: