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In this issue, Griffith et al. present one of the most comprehensive genome-sequence data sets to date from a patient with myeloid leukemia, including sequencing of normal tissue, primary cancer, and a relapse. Their raw data from a variety of sequencing methods along with a set of validated somatic variant calls provide a valuable resource that can be used to benchmark somatic mutation calling. Benchmarking against resources such as this will let Next Generation Sequencing be used for clinical decision making with confidence.