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Publication Citation: Frictional properties of native and functionalized type I collagen thin films

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Author(s): Koo-hyun Chung; Antony Chen; Christopher Anderton; Kiran Bhadriraju; Anne L. Plant; Brian G. Bush; Robert F. Cook; Frank W. DelRio;
Title: Frictional properties of native and functionalized type I collagen thin films
Published: October 02, 2013
Abstract: Frictional properties of native and fibronectin (FN)-functionalized type I collagen (COL) thin films were studied via atomic force microscopy. The COL lateral contact stiffness was dependent only on the hydration state, indicating that shear deformation was invariant with FN. In contrast, the COL coefficient of friction and shear strength varied with both functionalization and hydration state. The changes in shear strength were found to correlate well with changes in mean cell spread area on the same thin films, suggesting that shear strength is a better indicator of cell spreading than heretofore considerations of film, and thus extracellular matrix, stiffness alone.
Citation: Applied Physics Letters
Keywords: atomic force microscopy; friction; collagen; fibronectin; cell behavior
Research Areas: Characterization
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