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|Author(s):||Koo-hyun Chung; Antony Chen; Christopher Anderton; Kiran Bhadriraju; Anne L. Plant; Brian G. Bush; Robert F. Cook; Frank W. DelRio;|
|Title:||Frictional properties of native and functionalized type I collagen thin films|
|Published:||October 02, 2013|
|Abstract:||Frictional properties of native and fibronectin (FN)-functionalized type I collagen (COL) thin films were studied via atomic force microscopy. The COL lateral contact stiffness was dependent only on the hydration state, indicating that shear deformation was invariant with FN. In contrast, the COL coefficient of friction and shear strength varied with both functionalization and hydration state. The changes in shear strength were found to correlate well with changes in mean cell spread area on the same thin films, suggesting that shear strength is a better indicator of cell spreading than heretofore considerations of film, and thus extracellular matrix, stiffness alone.|
|Citation:||Applied Physics Letters|
|Keywords:||atomic force microscopy, friction, collagen, fibronectin, cell behavior|
|PDF version:||Click here to retrieve PDF version of paper (1MB)|