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Publication Citation: Tools and Approaches for the Assessment of Nanomaterial Induced Oxidative DNA Damage

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Author(s): Elijah J. Petersen; Bryce Marquis; Pawel Jaruga; M Miral Dizdar; Bryant C. Nelson;
Title: Tools and Approaches for the Assessment of Nanomaterial Induced Oxidative DNA Damage
Published: May 13, 2013
Abstract: Hyphenated mass spectrometry techniques have been employed as one of the primary analytical tools for investigating the effects of ionizing radiation, chemical/biological carcinogens, and oxygen derived free radicals on the induction and subsequent repair of oxidatively-induced DNA damage (DNA lesions) in living systems. The National Institute of Standards and Technology has established a comprehensive research program focused on identifying mechanisms of DNA damage caused by commercially relevant engineered nanoparticles (NPs) using high resolution mass spectrometry for the quantification of oxidatively-induced DNA damage. We present results from a recently published study on the genotoxicity of National Institute of Standards and Technology (NIST) standard reference material (SRM) gold nanoparticles using isotope dilution liquid chromatography /mass spectrometry analysis.
Proceedings: Nanotech 2013
Location: Washington, DC
Dates: May 12-16, 2013
Research Areas: Nanotech/Environment, Health & Safety
PDF version: PDF Document Click here to retrieve PDF version of paper (236KB)