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Publication Citation: Tools and Approaches for the Assessment of Nanomaterial Induced Oxidative DNA Damage

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Author(s): Elijah J. Petersen; Bryce J. Marquis; Pawel Jaruga; M Miral Dizdar; Bryant C. Nelson;
Title: Tools and Approaches for the Assessment of Nanomaterial Induced Oxidative DNA Damage
Published: June 20, 2012
Abstract: Hyphenated mass spectrometry techniques have been employed as one of the primary analytical tools for investigating the effects of ionizing radiation, chemical/biological carcinogens, and oxygen derived free radicals on the induction and subsequent repair of oxidatively-induced DNA damage (DNA lesions) in living systems. The National Institute of Standards and Technology has established a comprehensive research program focused on identifying mechanisms of DNA damage caused by commercially relevant engineered nanoparticles (NPs) using these techniques for the quantification of oxidatively-induced DNA damage. We present an overview of our recent findings from studies on metal (gold) and metal oxide (ultrafine superparamagnetic iron oxide) nanoparticles using isotope dilution liquid chromatography and gas chromatography/mass spectrometry analysis, respectively.
Proceedings: Nanotech 2012
Pages: pp. 307 - 310
Location: Santa Clara, CA
Dates: June 18-21, 2012
Keywords: nanotoxicology, Comet assay, genotoxicity, biomarker, toxicology
Research Areas: Nanotech/Environment, Health & Safety
PDF version: PDF Document Click here to retrieve PDF version of paper (802KB)