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Publication Citation: Engineering and Analysis of Surface Interactions in a Microfluidic Herringbone Micromixer

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Author(s): Thomas P. Forbes; Jason G. Kralj;
Title: Engineering and Analysis of Surface Interactions in a Microfluidic Herringbone Micromixer
Published: May 18, 2012
Abstract: We developed a computational model and theoretical framework to investigate the geometrical optimization of particle-surface interactions in a herringbone micromixer. The enhancement of biomolecule- and particle-surface interactions in microfluidic devices through mixing and streamline disruption holds promise for a variety of applications. This analysis provides guidelines for optimizing the frequency and specific location of surface interactions based on the flow pattern and relative hydraulic resistance between a groove and the effective channel. The channel bottom, i.e., channel surface between grooves, was identified as the dominant location for surface contact. In addition, geometries that decrease the groove-to-channel hydraulic resistance improve contact with the channel top. Thus, herringbone mixers appear useful for a variety of surface-interaction applications; yet, they have largely not been employed in an optimized fashion.
Citation: Lab on A Chip
Volume: 12
Issue: 15
Pages: pp. 2634 - 2637
Keywords: Microfluidics; Surface Interactions; Numerical Analysis; Herringbone Mixer;
Research Areas: Microfluidics
DOI: http://dx.doi.org/10.1039/c2lc40356k  (Note: May link to a non-U.S. Government webpage)