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|Author(s):||Thomas P. Forbes; Jason G. Kralj;|
|Title:||Engineering and Analysis of Surface Interactions in a Microfluidic Herringbone Micromixer|
|Published:||May 18, 2012|
|Abstract:||We developed a computational model and theoretical framework to investigate the geometrical optimization of particle-surface interactions in a herringbone micromixer. The enhancement of biomolecule- and particle-surface interactions in microfluidic devices through mixing and streamline disruption holds promise for a variety of applications. This analysis provides guidelines for optimizing the frequency and specific location of surface interactions based on the flow pattern and relative hydraulic resistance between a groove and the effective channel. The channel bottom, i.e., channel surface between grooves, was identified as the dominant location for surface contact. In addition, geometries that decrease the groove-to-channel hydraulic resistance improve contact with the channel top. Thus, herringbone mixers appear useful for a variety of surface-interaction applications; yet, they have largely not been employed in an optimized fashion.|
|Citation:||Lab on A Chip|
|Pages:||pp. 2634 - 2637|
|Keywords:||Microfluidics, Surface Interactions, Numerical Analysis, Herringbone Mixer,|
|DOI:||http://dx.doi.org/10.1039/c2lc40356k (Note: May link to a non-U.S. Government webpage)|