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|Author(s):||Zachary H. Levine; Adam L. Pintar; John G. Hagedorn; Charles D. Fenimore; Claus P. Heussel;|
|Title:||Uncertainty in RECIST as a measure of volume for lung nodules and liver malignoma|
|Published:||April 27, 2012|
|Abstract:||The authors investigate the extent to which the RESPONSE Evaluation Criateria in Solid Tumors (RECIST) can predict tumor volumes and changes in volume using clinical data. The data presented are a reanalysis of data acquired in other studies, including the public database from the Lung Image Database Consortium (LID) and from a study of liver malignoma. The principal conclusion is that a given RECIST diameter predicts volume to a factor of 17 or 10 respectively with 95 % confidence and that changes in volume are predicted only a little better: to within a factor of 8 for the liver data. Additionally, we show the RECIST threshold of 10 mm to follow a nodule corresponds to a transition zone of a factor fo 10 in volume for the nodules in the LIDC database.|
|Pages:||pp. 2628 - 2637|
|Keywords:||RECIST , LIDC , nodule , volumetrics|
|Research Areas:||Bioscience & Health, Medical Devices|
|PDF version:||Click here to retrieve PDF version of paper (1MB)|