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Publication Citation: Uncertainty in RECIST as a measure of volume for lung nodules and liver malignoma

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Author(s): Zachary H. Levine; Adam L. Pintar; John G. Hagedorn; Charles D. Fenimore; Claus P. Heussel;
Title: Uncertainty in RECIST as a measure of volume for lung nodules and liver malignoma
Published: April 27, 2012
Abstract: The authors investigate the extent to which the RESPONSE Evaluation Criateria in Solid Tumors (RECIST) can predict tumor volumes and changes in volume using clinical data. The data presented are a reanalysis of data acquired in other studies, including the public database from the Lung Image Database Consortium (LID) and from a study of liver malignoma. The principal conclusion is that a given RECIST diameter predicts volume to a factor of 17 or 10 respectively with 95 % confidence and that changes in volume are predicted only a little better: to within a factor of 8 for the liver data. Additionally, we show the RECIST threshold of 10 mm to follow a nodule corresponds to a transition zone of a factor fo 10 in volume for the nodules in the LIDC database.
Citation: Medical Physics
Volume: 39
Issue: 5
Pages: pp. 2628 - 2637
Keywords: RECIST ; LIDC ; nodule ; volumetrics
Research Areas: Medical Devices, Bioscience & Health
PDF version: PDF Document Click here to retrieve PDF version of paper (1MB)