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Publication Citation: In situ monitoring of enzyme-catalyzed (co)polymerizations by Raman spectroscopy

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Author(s): Matthew T. Hunley; Atul Bhangale; Santanu S. Kundu; Peter M. Johnson; Michael S. Waters; Richard Gross; Kathryn L. Beers;
Title: In situ monitoring of enzyme-catalyzed (co)polymerizations by Raman spectroscopy
Published: November 10, 2011
Abstract: In situ, fiber optic-based Raman spectroscopy provided real time monitoring of enzyme-catalyzed ring-opening homo- and copolymerizations of ε-caprolactone (ε-CL) and δ-valerolactone (δ-VL). A custom designed reactor equipped with in situ fiber optic probe was used to measure monomer conversion as a function of time. The results from the in situ technique were in good agreement with those determined by offline 1H NMR analysis. Monomer reactivity ratios for the lipase-catalyzed copolymerization of ε-CL and δ-VL were estimated using the Kelen-Tudos method as rε-CL = 0.38 and rδ-VL = 0.29.
Citation: Polymer Chemistry
Keywords: Raman spectroscopy, enzyme-catalyzed polymerization, ring-opening polymerization, copolymerization, reactivity ratios
Research Areas: Characterization, Polymers, Raman
PDF version: PDF Document Click here to retrieve PDF version of paper (273KB)