| Author(s): |
Samuel M. Stavis; Jon C. Geist; Michael Gaitan; Laurie E. Locascio; Elizabeth A. Strychalski; |
| Title: |
DNA ENTROPOPHORESIS: A BALANCE OF ENTROPY AND DIFFUSION IN COMPLEX NANOCONFINEMENT |
| Published: |
October 03, 2011 |
| Abstract: |
Entropophoresis – motion caused by an entropy gradient – is a novel nanofluidic method to direct the self-transport of biopolymers that established a new paradigm of nanofluidic functionality with broad relevance to lab-on-a-chip technol-ogy. Here, the entropic effects on size variation of DNA molecules descending a nanofluidic staircase by entropophoresis are studied. A simple numerical model provides insight into the behavior of confined biopolymers – a controversial topic of basic importance in many lab-on-a-chip applications – and informs the rational design and self-operation of nanofluidic devices for future entropophoretic applications, such as the directed self-separation of biomolecular mixtures and directed self-patterning of biomolecular concentration gradients. |
| Conference: |
The 15th International Conference on Miniaturized Systems for Chemistry and Life sciences |
| Proceedings: |
DNA ENTROPOPHORESIS: A BALANCE OF ENTROPY AND DIFFUSION IN COMPLEX NANOCONFINEMENT |
| Location: |
Seattle, WA |
| Dates: |
October 2-6, 2011 |
| Keywords: |
Nanofluidics; DNA; Entropophoresis; Ideal chain; Polymer |
| Research Areas: |
Single Molecule Biophysics |
