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Publication Citation: DNA ENTROPOPHORESIS: A BALANCE OF ENTROPY AND DIFFUSION IN COMPLEX NANOCONFINEMENT

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Author(s): Samuel M. Stavis; Jon C. Geist; Michael Gaitan; Laurie E. Locascio; Elizabeth A. Strychalski;
Title: DNA ENTROPOPHORESIS: A BALANCE OF ENTROPY AND DIFFUSION IN COMPLEX NANOCONFINEMENT
Published: October 03, 2011
Abstract: Entropophoresis ‹ motion caused by an entropy gradient ‹ is a novel nanofluidic method to direct the self-transport of biopolymers that established a new paradigm of nanofluidic functionality with broad relevance to lab-on-a-chip technol-ogy. Here, the entropic effects on size variation of DNA molecules descending a nanofluidic staircase by entropophoresis are studied. A simple numerical model provides insight into the behavior of confined biopolymers ‹ a controversial topic of basic importance in many lab-on-a-chip applications ‹ and informs the rational design and self-operation of nanofluidic devices for future entropophoretic applications, such as the directed self-separation of biomolecular mixtures and directed self-patterning of biomolecular concentration gradients.
Conference: The 15th International Conference on Miniaturized Systems for Chemistry and Life sciences
Proceedings: DNA ENTROPOPHORESIS: A BALANCE OF ENTROPY AND DIFFUSION IN COMPLEX NANOCONFINEMENT
Location: Seattle, WA
Dates: October 2-6, 2011
Keywords: Nanofluidics; DNA; Entropophoresis; Ideal chain; Polymer
Research Areas: Single Molecule Biophysics