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|Author(s):||Samuel M. Stavis; Jon C. Geist; Michael Gaitan; Laurie E. Locascio; Elizabeth A. Strychalski;|
|Title:||DNA ENTROPOPHORESIS: A BALANCE OF ENTROPY AND DIFFUSION IN COMPLEX NANOCONFINEMENT|
|Published:||October 03, 2011|
|Abstract:||Entropophoresis ‹ motion caused by an entropy gradient ‹ is a novel nanofluidic method to direct the self-transport of biopolymers that established a new paradigm of nanofluidic functionality with broad relevance to lab-on-a-chip technol-ogy. Here, the entropic effects on size variation of DNA molecules descending a nanofluidic staircase by entropophoresis are studied. A simple numerical model provides insight into the behavior of confined biopolymers ‹ a controversial topic of basic importance in many lab-on-a-chip applications ‹ and informs the rational design and self-operation of nanofluidic devices for future entropophoretic applications, such as the directed self-separation of biomolecular mixtures and directed self-patterning of biomolecular concentration gradients.|
|Conference:||The 15th International Conference on Miniaturized Systems for Chemistry and Life sciences|
|Proceedings:||DNA ENTROPOPHORESIS: A BALANCE OF ENTROPY AND DIFFUSION IN COMPLEX NANOCONFINEMENT|
|Dates:||October 2-6, 2011|
|Keywords:||Nanofluidics, DNA, Entropophoresis, Ideal chain, Polymer|
|Research Areas:||Single Molecule Biophysics|