| Author(s): |
Carl G. Simon Jr; Kaushik Chatterjee; Limin Sun; Laurence C. Chow; Marian F. Young; |
| Title: |
Combinatorial Screening of Osteoblast Response to 3D Nano-Composite Tissue Scaffolds Using Gradients and Arrays |
| Published: |
April 24, 2011 |
| Abstract: |
Current methods for combinatorial and high-throughput (CHT) screening of cell-material interactions utilize a two-dimensional (2D) format where cells are presented on flat materials surfaces [1]. However, cell response in 3D scaffolds is more representative of their behavior in vivo [2]. Also, biomaterials must be fabricated into a 3D scaffold to generate a 3D tissue and cells are sensitive to topographical differences between 2D surfaces and 3D scaffolds. Thus, the objective in this work was to develop CHT methods to screen cell-material interactions in 3D. We used a bone tissue model to study osteoblast attachment and proliferation on porous poly(-caprolactone) (PCL) scaffolds containing amorphous calcium phosphate nanoparticles (nACP). nACP is highly soluble in water and releases calcium and phosphate ions that are known to enhance osteoblast response. |
| Conference: |
Society for Biomaterials |
| Pages: |
1 pp. |
| Location: |
Orlando, FL |
| Dates: |
April 13-16, 2011 |
| Keywords: |
polymer scaffold; osteoblast; cell adhesion; cell proliferation; |
| Research Areas: |
Ceramics, Ceramics, Polymers, Polymers, Materials Science, Biomaterials, Biomaterials, Biomaterials, Bioscience & Health, Advanced Materials |
