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|Author(s):||Carl G. Simon Jr.; Kaushik Chatterjee; Limin Sun; Laurence C. Chow; Marian F. Young;|
|Title:||Combinatorial Screening of Osteoblast Response to 3D Nano-Composite Tissue Scaffolds Using Gradients and Arrays|
|Published:||April 24, 2011|
|Abstract:||Current methods for combinatorial and high-throughput (CHT) screening of cell-material interactions utilize a two-dimensional (2D) format where cells are presented on flat materials surfaces . However, cell response in 3D scaffolds is more representative of their behavior in vivo . Also, biomaterials must be fabricated into a 3D scaffold to generate a 3D tissue and cells are sensitive to topographical differences between 2D surfaces and 3D scaffolds. Thus, the objective in this work was to develop CHT methods to screen cell-material interactions in 3D. We used a bone tissue model to study osteoblast attachment and proliferation on porous poly(-caprolactone) (PCL) scaffolds containing amorphous calcium phosphate nanoparticles (nACP). nACP is highly soluble in water and releases calcium and phosphate ions that are known to enhance osteoblast response.|
|Conference:||Society for Biomaterials|
|Dates:||April 13-16, 2011|
|Keywords:||polymer scaffold, osteoblast, cell adhesion, cell proliferation,|
|Research Areas:||Ceramics, Ceramics, Polymers, Polymers, Materials Science, Biomaterials, Biomaterials, Biomaterials, Bioscience & Health, Advanced Materials|