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Publication Citation: CONTINUOUS FLOW ENZYME-CATALYZED POLYMERIZATION IN A MICROREACTOR

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Author(s): Santanu S. Kundu; Atul S. Bhangale; William E. Wallace III; Kathleen M. Flynn; Charles M. Guttman; Richard Gross; Kathryn L. Beers;
Title: CONTINUOUS FLOW ENZYME-CATALYZED POLYMERIZATION IN A MICROREACTOR
Published: March 25, 2011
Abstract: Enzymes immobilized on solid supports are increasingly used for chemical transformation because the process is greener and sustainable. Here we use microreactors to study enzyme catalyzed ring opening polymerization of -caprolactone to polycaprolactone. A novel microreactor design enabled us to perform these heterogeneous reactions in continuous mode, in organic media, and at elevated temperatures. Using microreactors we achieved faster polymerization and higher molecular weight compared to those of batch reactors. This is the first demonstration of a solid supported enzyme-catalyzed polymerization reaction in continuous mode. While this study focused on polymerization reactions, it is evident that similar microreactor based platforms can readily be extended to other enzyme-based systems, for example, high throughput screening of new enzymes and to precision measurements of new processes where continuous flow mode is preferred.
Citation: Nature Chemistry
Volume: 133
Issue: 15
Pages: pp. 6006 - 6011
Keywords: microreactor; enzymatic catalysis; ring opening polymerization; lipase; polycaprolactone
Research Areas: Characterization, Mass Spectrometry, Polymers
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