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|Author(s):||Carl G. Simon Jr.; Sapun Parekh; Marcus T. Cicerone; Sheng Lin-Gibson; Kaushik Chatterjee; Marian F. Young;|
|Title:||Effect of 3D Hydrogel Scaffold Stiffness on Human Bone Marrow Stromal Cell Differentiation|
|Published:||November 01, 2010|
|Abstract:||There is growing recognition cells can sense and respond to the mechanical properties of tissue scaffolds and that these interactions are critical in optimizing scaffold design [1-4]. Previous studies in planar 2D culture format have shown that human bone marrow stromal cell (hBMSC) differentiation and proliferation change in response to change in stiffness of the underlying substrate. Herein, the effect of matrix modulus on differentiation of hBMSC within three-dimensional (3D) polyethylene glycol tetramethacrylate (PEGTM) hydrogel scaffolds is examined.|
|Proceedings:||RESBIO Cells on Polymeric Biomaterials|
|Dates:||October 26-29, 2010|
|Keywords:||tissue engineering, hydrogel scaffold, stem cell, cell differentiation, modulus|
|Research Areas:||Polymers, Materials Science, Biomaterials, Biomaterials, Bioscience & Health|
|PDF version:||Click here to retrieve PDF version of paper (243KB)|