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Publication Citation: Effect of 3D Hydrogel Scaffold Stiffness on Human Bone Marrow Stromal Cell Differentiation

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Author(s): Carl G. Simon Jr; Sapun Parekh; Marcus T. Cicerone; Sheng Lin-Gibson; Kaushik Chatterjee; Marian F. Young;
Title: Effect of 3D Hydrogel Scaffold Stiffness on Human Bone Marrow Stromal Cell Differentiation
Published: November 01, 2010
Abstract: There is growing recognition cells can sense and respond to the mechanical properties of tissue scaffolds and that these interactions are critical in optimizing scaffold design [1-4]. Previous studies in planar 2D culture format have shown that human bone marrow stromal cell (hBMSC) differentiation and proliferation change in response to change in stiffness of the underlying substrate. Herein, the effect of matrix modulus on differentiation of hBMSC within three-dimensional (3D) polyethylene glycol tetramethacrylate (PEGTM) hydrogel scaffolds is examined.
Proceedings: RESBIO Cells on Polymeric Biomaterials
Pages: 1 pp.
Location: Piscataway, NC
Dates: October 26-29, 2010
Keywords: tissue engineering; hydrogel scaffold; stem cell; cell differentiation; modulus
Research Areas: Polymers, Materials Science, Biomaterials, Biomaterials, Bioscience & Health
PDF version: PDF Document Click here to retrieve PDF version of paper (243KB)