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|Author(s):||Elizabeth A. Strychalski; Laurie E. Locascio; Samuel M. Stavis; Michael Gaitan;|
|Title:||Nanoslinky: DNA Entropophoresis Down a Nanofluidic Staircase|
|Published:||October 04, 2010|
|Abstract:||Almost all nanofluidic devices for biopolymer analysis have been limited by one or two confining structural dimen-sions or the application of external forces for biopolymer manipulation, which has restricted the scope of related lab-on-a-chip technology. Here, a nanofluidic channel with a three dimensional (3D) ,staircaseŠ depth profile across its width was used to control and measure the behavior of individual DNA molecules, which ,descendedŠ the confining staircase via ,entropophoresisŠ effected by interactions between the DNA molecules and the nanofluidic step edges. Thus, the nanofabricated staircase enabled complex structural control over DNA transport and conformation without the applica-tion of external forces.|
|Proceedings:||The 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences|
|Dates:||October 3-7, 2010|
|Keywords:||3D, DNA, Entropophoresis, Nanofluidics, Polymer, Separation|
|Research Areas:||Bioscience & Health|