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Publication Citation: Effect of 3D Hydogel Scaffold Modulus and Topology on Human Bone Marrow Stromal Cell Fate

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Author(s): Kaushik Chatterjee; Sheng Lin-Gibson; Sapun Parekh; Nicole M. Moore; Marcus T. Cicerone; marian F. young; Carl G. Simon Jr;
Title: Effect of 3D Hydogel Scaffold Modulus and Topology on Human Bone Marrow Stromal Cell Fate
Published: September 01, 2010
Abstract: There is growing recognition that cells can sense and respond to the physical cues from their environment, such as stiffness, mechanical loading and topology. Physical properties of the matrix can direct cellular response and are critical in the design of scaffolds for tissue engineering. In this work we examined the effect of matrix modulus on differentiation of human bone marrow stromal cells (hBMSCs) encapsulated within three-dimensional (3D) photo-polymerizable polyethylene glycol (PEG) hydrogels. Further, to investigate the topological effects of the hydrogel scaffolds on cellular differentiation we studied the response of hBMSCs on the gel surface (2D) and those encapsulated within the hydrogel (3D).
Proceedings: American Chemical Society
Pages: 2 pp.
Location: boston, MA
Dates: August 22-26, 2010
Keywords: hydrogel; scaffold; tissue engineering; stem cell
Research Areas: Biomaterials, Materials Science
PDF version: PDF Document Click here to retrieve PDF version of paper (1MB)