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|Author(s):||Kaushik Chatterjee; Marian F. Young; Carl G. Simon Jr.;|
|Title:||Combinatorial Screening of Hydrogel Scaffolds for 3D Cell Culture|
|Published:||May 02, 2011|
|Abstract:||Optimizing cell-material interactions is critical towards maximizing regeneration in tissue engineering. Combinatorial and high-throughput (CHT) methods can be used to systematically screen tissue scaffolds to identify optimal biomaterial properties. Previous CHT platforms in tissue engineering have involved a two-dimensional (2D) cell culture format where cells were cultured on material surfaces. However, these platforms are inadequate to predict cellular response in a three-dimensional (3D) tissue scaffold. We describe a simple CHT platform to screen cell-material interactions in 3D culture format that can be applied to screen hydrogel scaffolds. Herein we focus on a method to prepare gradients in elastic modulus of photopolymerizable hydrogels.|
|Citation:||Methods In Bioengineering|
|Publisher:||Artech House, Norwood, MA|
|Keywords:||combinatorial methods, high-throughput screening, hydrogels, elastic modulus, gradients, osteoblast, tissue engineering|
|Research Areas:||Polymers, Combinatorial Methods, Life Sciences Research, Biomaterials, Biomaterials|