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|Author(s):||Brian D. Cloteaux; Nadezhda Serova;|
|Title:||Matching Observed Alpha Helix Lengths to Predicted Secondary Structure|
|Published:||November 01, 2009|
|Abstract:||Because of the complexity in determining the 3D structure of a protein, the use of partial information determined from experimental techniques can greatly reduce the overall computational expense. We investigate the problem of matching experimentally observed lengths of helices to the predicted secondary structure of a protein. We give a simple and fast algorithm for producing a library of possible solutions. Then we test our algorithm by performing a series of computational experiments of predicting the alpha helix placement of proteins with an already known order. These tests seem to demonstrate that our method, if given a good prediction of the protein s secondary structure, can generate high quality lists of potential placements of the helix length onto the protein sequences.|
|Proceedings:||Computational Structural Bioinformatics Workshop|
|Pages:||pp. 113 - 119|
|Dates:||November 1-4, 2009|
|Keywords:||protein structure, randomized algorithm|
|Research Areas:||Scientific Computing|
|PDF version:||Click here to retrieve PDF version of paper (159KB)|