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Publication Citation: Identification of a Highly-Specific Hydroxyapatite-Binding Peptide Using Phage Display

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Author(s): Matthew Becker; Marc Roy; Scott K. Stanley; Eric J. Amis;
Title: Identification of a Highly-Specific Hydroxyapatite-Binding Peptide Using Phage Display
Published: May 19, 2008
Abstract: Using a phage display approach we have identified a peptide sequence SVSVGMKPSPRP that selectively recognizes HA over amorphous calcium phosphate. Exploitation of the recognition properties of such peptidic species to specific polymorphs deposited during mineralization processes and in hydroxyapatite (HA)-derivatized composites may be useful in future studies for monitoring the progression of mineralization and potentially cell differentiation in situ as opposed to destructive endpoint measurements.
Citation: Advanced Materials
Keywords: biomineralization;hydroxyapatite;phage display;quartz crystal microbalance;tooth
Research Areas: Biomaterials