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Publication Citation: Maturation Stage Dependent Interaction of Mature Osteoblasts and Osteoprogenitor Cells with Microvascular Endothelial Cells

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Author(s): Erica Takai; Rocky Tuan; Steven D. Hudson;
Title: Maturation Stage Dependent Interaction of Mature Osteoblasts and Osteoprogenitor Cells with Microvascular Endothelial Cells
Published: February 14, 2007
Abstract: Angiogenesis is essential to the development, maintenance, and repair of bone tissue, as well as the survival of engineered tissues. Also, since osteoblasts (OB) are found in close proximity to endothelial cells in areas of new bone formation, it has been postulated that communication exists between these cell populations. Indeed, recent in vitro studies have shown that endothelial cells produce growth factors for OBs. In turn, OBs and osteoprogenitors have been found to produce angiogenic factors, while mature OBs also produce anti-angiogenic factors, suggesting that OBs are capable of modulating angiogenesis in bone in a maturation dependent manner. However, the cellular mechanisms behind OB-endothelial cell interactions during angiogenesis and bone formation remain unclear, particularly the influence of OB maturation.
Conference: Transactions of Annual Meeting of the Orthopaedic Research Society
Proceedings: Annual Meeting of the Orthopaedic Research Society | 53rd | | Orthopaedic Research Society
Pages: pp. 1 - 1
Location: San Diego, CA
Dates: February 11-14, 2007
Keywords: co-culture;endothelial cell;osteoblast;transwell
Research Areas: Biomaterials
PDF version: PDF Document Click here to retrieve PDF version of paper (120KB)