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Publication Citation: Solid-Phase ATRP Synthesis of Peptide-Polymer Hybrids

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Author(s): Ying Mei; Kathryn L. Beers; H M. Byrd; David L. VanderHart; N. R. Washburn;
Title: Solid-Phase ATRP Synthesis of Peptide-Polymer Hybrids
Published: March 01, 2004
Abstract: A versatile methodology for preparing hybrid biomaterials by atom transfer radical polymerization from resin-supported peptides has been established. As an example, we have synthesized a GRGDS-functionalized poly(2-hydroxyethyl methacrylate). The peptide-polymer was characterized by 1H NMR and GPC and found to have a number average molecular weight of 3900 and a polydispersity of 1.47. These values are comparable to those obtained from solution-phase syntheses, suggesting it is possible to retain significant control over the polymerization from a peptide-conjugated solid support. Solid state 13C NMR was used to characterize multiple steps in the reaction and the synthesis was found to go to near-completion. We have performed cell adhesion experiments and observed the GRGDS sequence promoted cell adhesion.
Citation: Journal of the American Chemical Society
Volume: 126
Issue: No. 11
Keywords: biomaterials,polymers,synthesis
Research Areas: Hybrid Materials, Biomaterials
PDF version: PDF Document Click here to retrieve PDF version of paper (107KB)