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Publication Citation: Cold Chain Storage of Vaccines: A Brief Introduction to Thermometry

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Author(s): Dean C. Ripple;
Title: Cold Chain Storage of Vaccines: A Brief Introduction to Thermometry
Published: September 01, 2008
Abstract: To maintain the efficacy of vaccines requires maintaining the storage temperature within well-defined limits; vaccine failure due to improper storage results in large direct and indirect public health costs. In this presentation, I give a brief introduction to thermometry and related techniques in measurement science. Topics covered include: a description of the measurement problem; an overview of sensor types; a description of what it means to have traceability to NIST; methods for measurement assurance; measurement uncertainty and error allowances; the difference between certification and calibration; and the proper use of thermometers. At the end of the talk, I give answers to a number of common questions regarding temperature measurements and traceability within the vaccine cold chain.
Citation: NIST Interagency/Internal Report (NISTIR) -
Keywords: cold chain; freezer; ITS-90; refrigerator; storage; temperature; thermometer; traceability
Research Areas: Thermometry, Drugs/Pharmaceuticals
PDF version: PDF Document Click here to retrieve PDF version of paper (614KB)