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Publication Citation: Self-Assembled Monolayers of an Oligo(ethylene oxide) Disulfide and its Corresponding Thiol Assembled From Water: Characterization and Protein Resistance

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Author(s): David J. Vanderah; Marlon L. Walker; Mark A. Rocco; Kenneth A. Rubinson;
Title: Self-Assembled Monolayers of an Oligo(ethylene oxide) Disulfide and its Corresponding Thiol Assembled From Water: Characterization and Protein Resistance
Published: February 05, 2008
Abstract: The self-assembled monolayers (SAMs) of the ?-methyl oligo(ethylene oxide) disulfide [S(CH2CH2O)6CH3]2, [S(EO)6]2 {OEO disulfide}, on Au from 95 % ethanol and from water are described. Spectroscopic ellipsometry and reflection-absorption infrared spectroscopy data indicate the [S(EO)6]2 films are similar to the disordered films of HS(CH2CH2O)6CH3, (EO)6, and HS(CH2)3O(CH2CH2O)5CH3, C3EO5, at their protein adsorption minima. However, unlike the (EO)6 and C3EO5 thiols, the [S(EO)6]2 films are self-limiting in their surface packing density and sustain film thickness of 1.0 nm to 1.3 nm, corresponding to 50 % to 65 % coverage, over extended periods of time. As a result, OEO disulfides offer an attractive motif for the generation of thin, protein rejecting surfaces.
Citation: Langmuir
Volume: 24
Issue: 3
Pages: pp. 826 - 829
Keywords: Oligo(ethylene oxide) disulfides;self-assembled monolayers (SAMs)
Research Areas: Organic Analytical Chemistry