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Publication Citation: Highly Multiplexed Assays for Measuring Polymorphisms on the Y-Chromosome

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Author(s): John M. Butler; R Schoske; Peter M. Vallone;
Title: Highly Multiplexed Assays for Measuring Polymorphisms on the Y-Chromosome
Published: October 17, 2003
Abstract: A multiplex PCR assay capable of amplifying 20 Y chromosome short tandem repeat (STR) markers simultaneously has been developed. These markers include all of the Y STRs that make up the extended haplotype used in Europe (DYS19, DYS385, DYS389I/II, DYS390, SYS391, DYS392, DYS393, and YCAII) plus additional polymorphic Y STRs DYS437, DYS438, DYS439, DYS447, DYS448, DYS388, DYSS426, GATA A7.1, and GATA H4. Single nucleotide polymorphism (SNP) assays that may be rapidly analyzed with time-of-flight mass spectrometry have also been developed using Y chromosome bi-allelic markers. With improved multiplexes and techniques for more rapid data collection such as mass spectrometry, Y chromosome haplotypes maybe more quickly generated for DNA databases and population studies and forensic cases may be solved more efficiently.
Conference: 19th International Congress of the International-Society-Forensic-Genetics
Proceedings: International Congress Series: Progress in Forensic Genetics
Volume: 9
Issue: 1239
Pages: pp. 301 - 305
Location: Munster, -1
Dates: August 28-September 1, 2001
Keywords: DNA typing,Y chromosome testing,Y SNPs,Y STRs
Research Areas: Gene Therapy, Homeland Security/Forensics/Human Identity, DNA, Bioscience & Health