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|Author(s):||John M. Butler; R Schoske; Peter M. Vallone;|
|Title:||Highly Multiplexed Assays for Measuring Polymorphisms on the Y-Chromosome|
|Published:||October 17, 2003|
|Abstract:||A multiplex PCR assay capable of amplifying 20 Y chromosome short tandem repeat (STR) markers simultaneously has been developed. These markers include all of the Y STRs that make up the extended haplotype used in Europe (DYS19, DYS385, DYS389I/II, DYS390, SYS391, DYS392, DYS393, and YCAII) plus additional polymorphic Y STRs DYS437, DYS438, DYS439, DYS447, DYS448, DYS388, DYSS426, GATA A7.1, and GATA H4. Single nucleotide polymorphism (SNP) assays that may be rapidly analyzed with time-of-flight mass spectrometry have also been developed using Y chromosome bi-allelic markers. With improved multiplexes and techniques for more rapid data collection such as mass spectrometry, Y chromosome haplotypes maybe more quickly generated for DNA databases and population studies and forensic cases may be solved more efficiently.|
|Conference:||19th International Congress of the International-Society-Forensic-Genetics|
|Proceedings:||International Congress Series: Progress in Forensic Genetics|
|Pages:||pp. 301 - 305|
|Dates:||August 28-September 1, 2001|
|Keywords:||DNA typing,Y chromosome testing,Y SNPs,Y STRs|
|Research Areas:||Gene Therapy, Homeland Security/Forensics/Human Identity, DNA, Bioscience & Health|