| Author(s): |
Andreas Jahn; Joseph E. Reiner; Wyatt N. Vreeland; Don DeVoe; Laurie E. Locascio; Michael Gaitan; |
| Title: |
Controlled Encapsulation of a Hydrophilic Drug Simulant in Nano-Liposomes Using Continuous Flow Microfluidics |
| Published: |
June 04, 2008 |
| Abstract: |
A new method to tailor the size and size distribution of nanometer scale liposomes and control loading of liposomes with a model drug in a continuous-flow microfluidic design is presented. Size and size dispersion are determined with tandem Asymmetric Flow Field Flow Fractionation (AF4) and Multi-Angle Laser Light Scattering (MALLS). Fluorescence Correlation Spectroscopy (FCS) combined with Fluorescence Cumulant Analyis (FCA) allow for determining the number of encapsulated molecules [1]. Results show that this system allows for control of loading efficiency as well as minimization of encapsulant consumption. |
| Proceedings: |
11th Annual Nano Science and Technology Institute (NSTI) Nanotech 2008 |
| Pages: |
4 pp. |
| Location: |
Boston, MA |
| Dates: |
June 1-5, 2008 |
| Keywords: |
liposomes; encapsulation; fluorescence spectroscopy; hydrodynamic focusing; microfluidics |
| Research Areas: |
Nanoelectronics and Nanoscale Electronics |
| PDF version: |
 Click here to retrieve PDF version of paper (209KB) |
