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Publication Citation: Controlled Encapsulation of a Hydrophilic Drug Simulant in Nano-Liposomes Using Continuous Flow Microfluidics

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Author(s): Andreas Jahn; Joseph E. Reiner; Wyatt N. Vreeland; Don DeVoe; Laurie E. Locascio; Michael Gaitan;
Title: Controlled Encapsulation of a Hydrophilic Drug Simulant in Nano-Liposomes Using Continuous Flow Microfluidics
Published: June 04, 2008
Abstract: A new method to tailor the size and size distribution of nanometer scale liposomes and control loading of liposomes with a model drug in a continuous-flow microfluidic design is presented. Size and size dispersion are determined with tandem Asymmetric Flow Field Flow Fractionation (AF4) and Multi-Angle Laser Light Scattering (MALLS). Fluorescence Correlation Spectroscopy (FCS) combined with Fluorescence Cumulant Analyis (FCA) allow for determining the number of encapsulated molecules [1]. Results show that this system allows for control of loading efficiency as well as minimization of encapsulant consumption.
Proceedings: 11th Annual Nano Science and Technology Institute (NSTI) Nanotech 2008
Pages: 4 pp.
Location: Boston, MA
Dates: June 1-5, 2008
Keywords: liposomes; encapsulation; fluorescence spectroscopy; hydrodynamic focusing; microfluidics
Research Areas: Nanoelectronics and Nanoscale Electronics
PDF version: PDF Document Click here to retrieve PDF version of paper (214KB)