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|Author(s):||Andreas Jahn; Joseph E. Reiner; Wyatt N. Vreeland; Don DeVoe; Laurie E. Locascio; Michael Gaitan;|
|Title:||Controlled Encapsulation of a Hydrophilic Drug Simulant in Nano-Liposomes Using Continuous Flow Microfluidics|
|Published:||June 04, 2008|
|Abstract:||A new method to tailor the size and size distribution of nanometer scale liposomes and control loading of liposomes with a model drug in a continuous-flow microfluidic design is presented. Size and size dispersion are determined with tandem Asymmetric Flow Field Flow Fractionation (AF4) and Multi-Angle Laser Light Scattering (MALLS). Fluorescence Correlation Spectroscopy (FCS) combined with Fluorescence Cumulant Analyis (FCA) allow for determining the number of encapsulated molecules . Results show that this system allows for control of loading efficiency as well as minimization of encapsulant consumption.|
|Proceedings:||11th Annual Nano Science and Technology Institute (NSTI) Nanotech 2008|
|Dates:||June 1-5, 2008|
|Keywords:||liposomes, encapsulation, fluorescence spectroscopy, hydrodynamic focusing, microfluidics|
|Research Areas:||Nanoelectronics and Nanoscale Electronics|
|PDF version:||Click here to retrieve PDF version of paper (214KB)|