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Drugs/Pharmaceuticals Programs & Projects

(showing 1 - 14 of 14)
HDX-MS for Biopharmaceutical Analysis
Last Updated Date: 12/08/2014

This project applies hydrogen/deuterium exchange mass spectrometry (HDX-MS) for determining the dynamical structure of therapeutic antibodies, … more

Web Force-Field (WebFF) - A Smart Force Field Repository for Soft Materials
Last Updated Date: 04/17/2014

As part of our mission to support the Materials Genome Initiative (MGI), we are developing data repositories and tools that support Integrated … more

Fluid Suspensions & Emulsions
Last Updated Date: 04/16/2014

Our primary interest is protein solution rheology and stability, involving bulk and interfacial properties and complemented by model solution … more

Storage stability of Freeze-Dried Proteins
Last Updated Date: 04/15/2014

We are resolving critical measurement issues that prevent researchers from reliably predicting the chemical and physical storage stability of … more

Monoclonal Antibody MS Libraries
Last Updated Date: 10/21/2013

The National Institute of Standards and Technology is developing a mass spectral library of all identifiable components derived from the digestion … more

Microcalorimetry of biopharmaceuticals
Last Updated Date: 09/19/2013

We are using calorimetry to probe several key aspects of biopharmaceuticals related to safety and efficacy. Microcalorimetry can be used to … more

Protein rheology measurements
Last Updated Date: 09/16/2013

Therapeutic protein solutions are highly concentrated during manufacturing purification processes and in finished dosage. At such concentrations, … more

Tandem Mass Spectral Library
Last Updated Date: 07/10/2013

The National Institute of Standards and Technology is responsible for an evaluated, tandem mass spectral library as an extension of the … more

Development of a Collagen Fibril Reference Material for Reproducible Cell Response
Last Updated Date: 01/11/2013

An important determinant of cellular response to drugs and toxins is the chemical and physical nature of the extracellular matrix (ECM) to which … more

Improved Benchtop Connectivity to Complex Microfluidic Devices
Last Updated Date: 10/10/2012

Despite their promise to enable high-throughput science and discovery, microfluidic devices have not yet been broadly adopted. An important … more

Chemical Characterization of Nanomaterial Formulations for Cancer Treatment in Support of the NCI Nanotechnology Characterization Laboratory
Last Updated Date: 10/02/2012

New generations of nanoparticles are being developed to provide early-stage detection and treatment of cancer. Much of the evaluative work on … more

Next-Generation Metrology for Drug Delivery Systems
Last Updated Date: 10/02/2012

A critical metrology issue for pharmaceutical industries is the application of analytical techniques to the characterization of drug delivery … more

Depth Profiling of Drug Eluting Stent Coatings with Cluster SIMS
Last Updated Date: 10/02/2012

There is much excitement in the cardiology community about drug eluting stents (DES), a promising new treatment for coronary artery disease. A … more

Structural Databases
Last Updated Date: 10/01/2012

We are witnessing the emergence of a web based "data rich" era on chemical and biological compounds. In order to make significant advances in this … more

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