Proteomics

News and Updates

Petri dish holds brown material with several different types of circular microbes.

Spotlight: Going With the Gut for the Future of Health

June 27, 2022

NIST researchers are developing a human gut microbiome reference material.

Woman uses gas analysis mass spectrometer at NBS for chemical analysis of gas or vapor mixtures

NIST Adds New 'Fingerprints' to Chemical Identification Database

June 17, 2020

The National Institute of Standards and Technology (NIST) has updated its database of chemical fingerprints, called mass spectra, that are used to identify

A Solution to a Hairy Problem in Forensic Science

November 5, 2019

In an effort to make hair comparison a more useful technique for investigating crimes, scientists at the National Institute of Standards and Technology (NIST)

Projects and Programs

Trusted AI framework for a new class of Standard Reference Materials and Data with exquisitely characterized uncertainty for billions of properties

Ongoing

A new collaboration between NIST's Human Genomics Team, Mass Spectrometry Data Center, and Information Technology Laboratory to use and develop artificial

Performance Metrics for Proteomics

Ongoing

In collaboration with the National Cancer Institute's Clinical Proteomic Technologies for Cancer (CPTC), NIST researchers are developing specific and

Comparative Serum Proteomics Project

Ongoing

Initially the Comparative Mammalian Proteome Aggregator Resource (CoMPARe) Program will generate proteomic data from sera from 25 different species that

Consistency Analysis and Uncertainty in ‘omic Data

Ongoing

As ‘omics moves into industrial and commercial applications, there is a need for quality and process control to ensure safety and efficacy of products and

Publications

Comprehensive Overview of Bottom-Up Proteomics using Mass Spectrometry

June 4, 2024

Author(s)

Yuming Jiang, Devasahayam Rex, Dina Schuster, Ben Neely, German Rosano, Norbert Volkmar, Amanda Momenzadeh, Trenton Peters-Clarke, Susan Egbert, Simion Kreimer, Emma Doud, Oliver Cook, Amit Yadav, Muralidharan Vanuopadath, Martin Mayta, Anna Duboff, Nicholas Riley, Robert Moritz, Jesse Meyer

Proteomics is the large scale study of protein structure and function from biological systems through protein identification and quantification. "Shotgun

Identification of Candidate Protein Biomarkers Associated with Domoic Acid Toxicosis in Cerebrospinal Fluid of California Sea Lions (Zalophus californianus)

May 28, 2024

Author(s)

Gautam Ghosh, Ben Neely, Alison Bland, Emily Whitmer, Cara Field, Pádraig Duignan, Michael Janech

Since 1998, California sea lion (Zalophus californianus) stranding events associated with domoic acid toxicosis have consistently increased. Currently there are

Reference Measurement Procedure for the Absolute Quantification of Albumin in Urine Using Isotope Dilution-Liquid Chromatography-Tandem Mass Spectrometry (ID-LC-MS/MS)

May 21, 2024

Author(s)

Ashley Beasley Green, N. Alan Heckert

Urinary excretion of albumin is a major diagnostic and prognostic marker of kidney disease; therefore, accurate measurement of urine albumin is essential to

Comparison of N-glycopeptide to released N-glycan abundances and the influence of glycopeptide mass and charge state on N-linked glycosylation of IgG antibodies

March 7, 2024

Author(s)

Concepcion Remoroza, Meghan Burke Harris, Tytus Mak, Sergey Sheetlin, Yuri Mirokhin, Zachary Goecker, Brian T. Cooper, Mark Lowenthal, Xiaoyu (Sara) Yang, Guanghui Wang, Dmitrii V. Tchekhovskoi, Stephen E. Stein

We report the comparison of mass-spectral-based abundances of tryptic glycopeptides to fluorescence abundances of released labeled glycans and the effects of

Awards

John Marino Honored with Hillebrand Prize

John Marino is recognized for his groundbreaking contributions to the field of biophysical characterization by high-resolution NMR and