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You searched on: Topic Area: Life Sciences Research

Displaying records 61 to 70 of 139 records.
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61. Comparison of Reagents for Shape Analysis of Fixed Cells by Automated Fluorescence Microscopy
Topic: Life Sciences Research
Published: 4/1/2003
Authors: John T Elliott, Alessandro Tona, Anne L Plant
Abstract: Background: Cell size and shape have been implicated as potentiators intracellular signaling events and as indicator of abnormal cell behavior. Automated microscopy and image analysis can provide quantitative information about the size and shape of ...

62. Primary Fibroblasts of Cockayne Syndrome Patients Are Defective in Cellular Repair of 8-Hydroxyguanine and 8-Hydroxyadenine Resulting From Oxidative Stress
Topic: Life Sciences Research
Published: 4/1/2003
Authors: J Tuo, Pawel Jaruga, H Rodriguez, V. Bohr, M Miral Dizdar
Abstract: Cockayne Syndrome (CS) is a genetic human disease with clinical symptoms that include neurodegeneration and premature aging. We show that primary fibroblasts from CS patients lack the ability to efficiently repair oxidative DNA damage. Primary fibr ...

63. Arabidopsis Thaliana Ogg1 Protein Excises 8-Hydroxyguanine and 2,6- Diamino-4-hydroxy-5-formamidopyrimidine from Oxidative Damaged DNA Containing Multiple Lesions
Topic: Life Sciences Research
Published: 3/18/2003
Authors: T Morales-Ruiz, M Birincioglu, Pawel Jaruga, H Rodriguez, T. Roldan-Arjona, M Miral Dizdar
Abstract: A functional homologue of eukaryotic Ogg1 proteins in the model plant Arabidopsis thaliana has recently been cloned, isolated, and characterized [Garcia-Ortiz, M.V., Ariza, R.R., and Roldan-Arjona, T. (2001) Plant Mol. Biol. 47, 795-804]. This enzym ...

64. Thin Films of Collagen Affect Smooth Muscle Cell Morphology
Topic: Life Sciences Research
Published: 3/4/2003
Authors: John T Elliott, Alessandro Tona, John Taylor Woodward IV, P L Jones, Anne L Plant
Abstract: The purpose of this study was to provide a reproducible method for applying collagen to surfaces on which cells can be grown, and to characterize the resulting thin films of collagen protein with respect to molecular structure and cellular response.C ...

65. Oxidative DNA Damage Biomarkers Used in Tissue Engineered Skin
Topic: Life Sciences Research
Published: 1/1/2003
Authors: H Rodriguez, Pawel Jaruga, M Birincioglu, Peter E. Dr. Barker, C D O'Connell, M. Dizdaroglu
Abstract: To assure that tissue engineered medical products are free of genetic changes that might occur from inflammation during the development phase of the product, our laboratory is responding to the need for test methods used to assess the safety and perf ...

66. Design and Use of a Peptide Nucleic Acid for Detection of the Heteroplasmic Low-Frequency Mitochondrial Encephalomyopathy, Lactic Acidosis, and Stroke-Like Episodes (MELAS) Mutation in Human Mitochondrial DNA
Topic: Life Sciences Research
Published: 12/1/2002
Authors: Diane K. Hancock, Frederick P. Schwarz, F H Song, L J Wong, Barbara C. Levin
Abstract: Most pathogenic human mitochondrial DNA (mtDNA) mutations are Heteroplasmic and are difficult to detect when present at very low levels in a population of normal mtDNA molecules. This paper describes a simple methodology to detect low levels of the s ...

67. Reaction Mechanism of Chorismate Mutase Studied by the Combined Potentials of Quantum Mechanics and Molecular Mechanics
Topic: Life Sciences Research
Published: 11/21/2002
Authors: Y. S. Lee, S. E. Worthington, Morris Krauss, B R Brooks
Abstract: The reaction path for the rearrangement of chorismate to prephenate has been determined in a QM/MM study including the entire protein environment while treating the reaction with ab initio quantum chemistry. In addition to the reactant, chorismate, t ...

68. Importance of Product Inhibition in the Kinetics of the Acylase Hydrolysis Reaction by Differential Stopped Flow Microcalorimetry
Topic: Life Sciences Research
Published: 9/15/2002
Authors: M Stodeman, Frederick P. Schwarz
Abstract: The hydrolysis of N-acetyl-L-methionine, N-acetylglycine, N-acetyl-L-phenylalanine, and N-acetyl-L-alanine at 298.35 K by porcine kidney acylase I (EC was monitored by the heat released upon mixing of the substrate and enzyme in a different ...

69. The Cockayne Syndrome Group B Gene Product is Involved in Cellular Repair of 8-Hydroxyadenine in DNA
Topic: Life Sciences Research
Published: 8/23/2002
Authors: J Tuo, Pawel Jaruga, H Rodriguez, M Miral Dizdar, V. Bohr
Abstract: Cockayne syndrome (CS) is a human disease characterized by sensitivity to sunlight, severe neurological abnormalities and accelerated aging. CS has two complementation groups, CS-A and CS-B. The CSB gene encodes the CSB protein with 1493 amino acid ...

70. Crystal Structure of the YjeE Protein from Haemophilus Influenzae: A Putative Atpase Involved in Cell Wall Synthesis
Topic: Life Sciences Research
Published: 8/1/2002
Authors: A Teplyakov, G Obmolova, M Tordova, N Thanki, N Bonander, E Eisenstein, A J Howard, G L. Gilliland
Abstract: A hypothetical protein encoded by the gene YjeE of Haemophilus influenzae was selected as part of a structural genomics project, for X-ray analysis to assist with the functional assignment. The protein is considered essential to bacteria since the ge ...

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