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You searched on: Topic Area: Life Sciences Research

Displaying records 61 to 70 of 145 records.
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61. DNA Base Damage by the Antitumor Agent 3-Amino-1,2,4-Benzotriazine 1,4-Dioxide (Tirapazamine)
Topic: Life Sciences Research
Published: 9/24/2003
Authors: M Birincioglu, Pawel Jaruga, G Chowdhury, H Rodriguez, M Miral Dizdar, K Gates
Abstract: Tirapazamine is a bioreductively activated DNA-damaging agent that selectively kills the hypoxic cells found in solid tomors. This compound shows great clinical promise and is currently being examined in a variety of clinical trails, including sever ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=830363

62. Crystal Structure of the YchF Protein Reveals Binding Sites for GTP and Nucleic Acid
Topic: Life Sciences Research
Published: 7/1/2003
Authors: A Teplyakov, G Obmolova, S Y Chu, J Toedt, E Eisenstein, A J Howard, G L. Gilliland
Abstract: The bacterial protein encoded by the gene ychF is 1 of 11 universally conserved GTPases, and the only one whose function is unknown. The crystal structure determination of YchF was sought to help with the the functional assignment of the protein. ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=830360

63. Genomic DNA of Nostoc Commune (Cyanobacteria) Becomes Covalently Modified During Long-Term (Decades) Desiccation But Is Protected From Oxidative Damage and Degradation
Topic: Life Sciences Research
Published: 6/15/2003
Authors: B Shirkey, N J McMaster, Sue C Smith, D J Wright, H Rodriguez, Pawel Jaruga, M Birincioglu, R F Helm, M Potts
Abstract: Genomic DNA of Nostoc commume (Cyanobacteria) became covalently modified during decades of desiccation. Amplification of gene loci from desiccated cells required pretreatment of DNA with N-phenacylthiazolium bromide; a reagent that cleaves DNA- and ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=830392

64. Standard Reference Material for Her2 Testing: Report of a National Institute of Standards and Technology-Sponsored Consensus Workshop
Topic: Life Sciences Research
Published: 6/1/2003
Authors: M E Hammond, Peter E. Dr. Barker, S Taube, S Gutman
Abstract: A workshop was sponsored by National Institute of Standards and Technology (NIST) Cancer Diagnosis Program of National Cancer Institute (CDP NCI), Food and Drug Administration (FDA), and College of American Pathologists (CAP) to address the need for ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=830374

65. Specific Antibody-DNA Interaction: A Novel Strategy for Tight DNA Recognition
Topic: Life Sciences Research
Published: 5/27/2003
Authors: S M Di Pietro, J M Centeno, M L Cerutti, M F Lodeiro, D U Ferreiro, L G Alonso, Frederick P. Schwarz, F Goldbaum, G de Prat-Gay
Abstract: Taking advantage of the extreme stability of a protein-DNA complex, we obtained highly specific monoclonal antibodies against a predetermined palindromic double stranded DNA sequence, corresponding to the binding site of the E2 transcriptional regula ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=830182

66. Crystal Structure of the Escherichia Coli YcdX Protein Reveals a Trinuclear Zinc Active Site
Topic: Life Sciences Research
Published: 5/1/2003
Authors: A Teplyakov, G Obmolova, P P Khil, A J Howard, R D Camerini-Otero, G L. Gilliland
Abstract: The ycdX gene of Escherichia coli encodes the protein of 27 kDa molecular weight that belongs to the PHP superfamily of proteins that have diverse functions. This superfamily includes several types of DNA polymerases (namely the a-subunit of bacteria ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=830361

67. Comparison of Reagents for Shape Analysis of Fixed Cells by Automated Fluorescence Microscopy
Topic: Life Sciences Research
Published: 4/1/2003
Authors: John T Elliott, Alessandro Tona, Anne L Plant
Abstract: Background: Cell size and shape have been implicated as potentiators intracellular signaling events and as indicator of abnormal cell behavior. Automated microscopy and image analysis can provide quantitative information about the size and shape of ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=830369

68. Primary Fibroblasts of Cockayne Syndrome Patients Are Defective in Cellular Repair of 8-Hydroxyguanine and 8-Hydroxyadenine Resulting From Oxidative Stress
Topic: Life Sciences Research
Published: 4/1/2003
Authors: J Tuo, Pawel Jaruga, H Rodriguez, V. Bohr, M Miral Dizdar
Abstract: Cockayne Syndrome (CS) is a genetic human disease with clinical symptoms that include neurodegeneration and premature aging. We show that primary fibroblasts from CS patients lack the ability to efficiently repair oxidative DNA damage. Primary fibr ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=830324

69. Arabidopsis Thaliana Ogg1 Protein Excises 8-Hydroxyguanine and 2,6- Diamino-4-hydroxy-5-formamidopyrimidine from Oxidative Damaged DNA Containing Multiple Lesions
Topic: Life Sciences Research
Published: 3/18/2003
Authors: T Morales-Ruiz, M Birincioglu, Pawel Jaruga, H Rodriguez, T. Roldan-Arjona, M Miral Dizdar
Abstract: A functional homologue of eukaryotic Ogg1 proteins in the model plant Arabidopsis thaliana has recently been cloned, isolated, and characterized [Garcia-Ortiz, M.V., Ariza, R.R., and Roldan-Arjona, T. (2001) Plant Mol. Biol. 47, 795-804]. This enzym ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=830365

70. Thin Films of Collagen Affect Smooth Muscle Cell Morphology
Topic: Life Sciences Research
Published: 3/4/2003
Authors: John T Elliott, Alessandro Tona, John Taylor Woodward IV, P L Jones, Anne L Plant
Abstract: The purpose of this study was to provide a reproducible method for applying collagen to surfaces on which cells can be grown, and to characterize the resulting thin films of collagen protein with respect to molecular structure and cellular response.C ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=830341



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