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Topic Area: Life Sciences Research

Displaying records 61 to 70 of 266 records.
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61. Measurement of formamidopyrimidines in DNA
Topic: Life Sciences Research
Published: 12/15/2008
Authors: Pawel Jaruga, Guldal Kirkali, M Miral Dizdar
Abstract: Formamidopyrimidines, 4,6-diamino-5-formamidopyrimidine (FapyAde) and 2,6-diamino-4-hydroxy-5-formamidopyrimidine (FapyGua), are among major lesions in DNA generated by hydroxyl radical attack, UV radiation or photosensitization in vitro and in vivo. ...

62. A New Protocol for Semi-Automatic Generation of Reference Data for High Resolution Biological Images
Topic: Life Sciences Research
Published: 11/30/2008
Authors: Adele P Peskin, Joe Chalfoun, Alden A Dima, James J Filliben
Abstract: We compare manually segmented masks of cell images that are independently hand-selected by several different people, with a new semi-automated method for estimating reference data for images of cells with very sharp clear edges. By quantifying the la ...

63. Soluble Amyloid beta-Oligomers Affect Dielectric Membrane Properties by Bilayer Insertion and Domain Formation: Implications for Cell Toxicity
Topic: Life Sciences Research
Published: 11/15/2008
Authors: Gintaras Valincius, Frank Heinrich, R Budvytye, David J Vanderah, Duncan J. McGillivray, Y Sokolov, J E Hall, Mathias Losche

64. Performance of mitochondrial DNA mutations detecting early stage cancer
Topic: Life Sciences Research
Published: 10/3/2008
Authors: J P. Jakupciak, Samantha D Maragh, Maura E Markowitz, Alissa K Greenberg, Mohammad O Hoque, A Maitra, Peter E. Dr. Barker, Paul D Wagner, William N Rom, Sudhir Srivastava, David Sidransky, Catherine D O'Connell

65. Thermodynamics of the hydrolysis reactions of 1,4-beta-D-xylobiose, 1,4-beta-D-xylotriose, D-cellobiose, and D maltose
Topic: Life Sciences Research
Published: 10/1/2008
Authors: Yadu D. Tewari, Brian E Lang, Stephen R. Decker, Robert Nathan Goldberg
Abstract: Microcalorimetry and high-performance liquid chromatography have been used to conduct a thermodynamic investigation of the following reactions: 1,4--D-xylobiose(aq) + H2O(l) = 2 D-xylose(aq), (1) 1,4--D-xylotriose + 2 H2O(l) = 3 ...

66. The Escherichia coli YdcF binds S-adenosyl-L-methionine and adopts an alpha/beta fold characteristic of nucleotide-utilizing enzymes
Topic: Life Sciences Research
Published: 7/1/2008
Authors: Kinlin L. Chao, Kap Lim, C Lehmann, V Doseeva, A J Howard, Frederick P. Schwarz, Osnat Herzberg
Abstract: The crystal structure of YdcF at a resolution of 0.18 nm reveals a fold of the adenine nucleotide α hydrolase-like family. Following the structural clues, a nucleotide binding screen was carried out employing isothermal titration calorimetry. Th ...

67. Effect of the Distal C162S Mutation on the Energetics of Drug Binding to p38 alpha MAP Kinase
Topic: Life Sciences Research
Published: 1/15/2008
Authors: Niya Todorova, V Doseeva, Jayanthi Ramprakash, Frederick P. Schwarz
Abstract: The binding constant, Kb, and the binding enthalpy (DbHo) of the inhibitor drugs, SB 203580, SKF 86002, and p38 INH.1 binding to two splice variants of p38a MAP kinase and their C162S mutants in 5mM HEPES buffer at pH =7.4 were determined from isoth ...

68. Epitope Selection of Monoclonal Antibodies for Interleukin-4 Quantification Using Suspension Arrays and Forward-Phase Protein Microarrays
Topic: Life Sciences Research
Published: 12/6/2007
Authors: Lili Wang, Kenneth D Cole, Hua-Jun He, Alexander W Peterson, Adolfas Kastytis Gaigalas, Y Zong
Abstract: A recombinant mouse interleukin-4 (IL-4) and three different purified rat anti-mouse IL-4 monoclonal antibodies (Mab) with different epitopes were employed as a model system. This system was used to examine monoclonal antibody effectiveness using bot ...

69. A Mycobacterium tuberculosis-derived Lipid Inhibits Membrane Fusion by Modulating Lipid Membrane Domains
Topic: Life Sciences Research
Published: 12/1/2007
Authors: E Hayakawa, F Tokumasu, G Nardone , A J Jin, Vincent A Hackley, J A Dvorak

70. Validation of Novel Optical Imaging Modalities: The Pathologists' View
Topic: Life Sciences Research
Published: 10/1/2007
Authors: W Wells, Peter E. Dr. Barker, C Macaulay, M Novelli, Richard Levenson, J Crawford
Abstract: Recent advances in optical imaging technology have the potential to improve the accuracy of disease detection and predict treatment response. The critical end-point for the success of any new imaging technology is clinical outcome. The following rev ...

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