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You searched on: Topic Area: Biomanufacturing Sorted by: date

Displaying records 1 to 10 of 13 records.
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1. Rheology of clustering protein solutions
Topic: Biomanufacturing
Published: 7/5/2016
Authors: Vishnu L Dharmaraj, P. Douglas Godfrin, Yun Liu, Steven D Hudson
Abstract: High viscosity is a major challenge with protein therapeutics at extremely high concentration. Understanding the relationship between the concentration of a protein solution and its viscosity as a function of shear rate and temperature is theref ...

2. Strategies for Achieving Measurement Assurance for Cell Therapy Products
Topic: Biomanufacturing
Published: 6/1/2016
Authors: Carl George Simon Jr., Anne L Plant, Sumona Sarkar, John T Elliott, Sheng Lin-Gibson
Abstract: Cell therapy products (CTPs) need quantitative, validated, and robust assays to support informed decision making during their development, manufacturing, and regulation. These products, the materials involved in their production and the methods f ...

3. Comparison of traditional 2-AB Fluorescence LC-MS/MS and automated microscale LC-MS for the comparative glycan analysis of monoclonal antibodies
Topic: Biomanufacturing
Published: 6/5/2015
Authors: John E Schiel, Michael T Boyne, Sarah M Rogstad
Abstract: Monoclonal antibody therapeutics are a heterogeneous mixture of glycoforms. Multiple methods exist for defining the glycan composition and relative abundance of species present. In the current report, two MS-based methods were compared for their ab ...

4. Monoclonal Antibody Therapeutics: The Need for Biopharmaceutical Reference Materials
Topic: Biomanufacturing
Published: 12/16/2014
Authors: John E Schiel, Anthony Mire-Sluis, Darryl Davis
Abstract: The use of naturally derived substances for therapeutic use has a longstanding history of success. Therapeutic monoclonal antibodies can be thought of in a similar light as they harness the highly evolved specificity of adaptive immunity to fight di ...

5. An interlaboratory comparison of sizing and counting of subvisible particles mimicking protein aggregates
Topic: Biomanufacturing
Published: 11/24/2014
Authors: Dean C Ripple, Christopher B Montgomery, Zhishang Hu
Abstract: Accurate counting and sizing of protein particles has been limited by discrepancies of counts obtained by different methods. To understand the bias and repeatability of techniques in common use in the biopharmaceutical community, the National Institu ...

6. Effects of Desialylation on Human alpha1-Acid Glycoprotein-Ligand Interactions
Topic: Biomanufacturing
Published: 9/16/2013
Authors: Richard Y. Huang, Jeffrey W Hudgens
Abstract: Human α1-Acid Glycoprotein (AGP), an acute phase glycoprotein, exists predominantly in blood. With its ability to bind basic, lipophilic, and acidic drugs, AGP has served as a drug carrier. It has been shown that the carbohydrate composition of ...

7. Quantitative Analysis of Dendron-Conjugated Cisplatin-Complexed Gold Nanoparticles Using Scanning Particle Mobility Mass Spectrometry
Topic: Biomanufacturing
Published: 5/8/2013
Authors: De-Hao D. Tsai, Tae Joon Cho, Sherrie R. Elzey, Julien C. Gigault, Vincent A Hackley
Abstract: We report a high-resolution and traceable method to quantify the drug loading on nanoparticle-based cancer therapeutics, and demonstrate this method using a model cisplatin functionalized dendron-gold nanoparticle (AuNP) conjugate. Electrospray diffe ...

8. Carbohydrate-Functionalized Surfactant Vesicles for Controlling Glycan Density
Topic: Biomanufacturing
Published: 3/15/2012
Authors: Monique A Makos, Rebecca A Zangmeister
Abstract: We report on the development of a method for rapidly characterizing the glycan binding properties of lectins. Catanionic surfactant vesicles were prepared that spontaneously formed in water and remained stable at room temperature for months. By var ...

9. O2 A-band line parameters to support atmospheric remote sensing. Part II: The rare isotopologues
Topic: Biomanufacturing
Published: 7/21/2011
Authors: Joseph Terence Hodges, David A Long, Daniel K Havey, S. S. Yu, M Okumura, Charles E Miller
Abstract: Frequency-stabilized cavity ring-down spectroscopy (FS-CRDS) was employed to measure over 100 transitions in the R-branch of the b1Σg+←X3Σg-(0,0) band for the rare O2 isotopologues. The use of 17O- and 18O-enriched mixtures allowed fo ...

10. PDH-locked, frequency-stabilized cavity ring-down spectrometer
Topic: Biomanufacturing
Published: 6/16/2011
Authors: Joseph Terence Hodges, A. Cygan, Piotr Maslowski, Katarzyna Ewelina Bielska, S. Wojtewicz, J. Domyslawska, H Abe, R.S. Trawinski, R. Ciurylo
Abstract: We describe a high sensitivity and high spectral resolution laser absorption spectrometer based upon the frequency-stabilized cavity ring-down spectroscopy (FS-CRDS) technique. We used the Pound-Drever-Hall (PDH) method to lock the probe laser to th ...

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