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You searched on: Author: john kasianowicz

Displaying records 21 to 30 of 64 records.
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21. Nanoscopic Porous Sensors
Published: 7/1/2008
Authors: John J Kasianowicz, Joseph William Robertson, Elaine Chan, Joseph E. Reiner, Vincent M Stanford
Abstract: There are thousands of different nanometer-scale pores in biology,many of which act as sensors for specific chemical agents. Recent work suggests that protein and solid-state nanopores have many potential uses in a wide variety of analytical applicat ...

22. Single molecule measurements within individual membrane-bound ion channels using a polymer-based bilayer lipid membrane chip
Published: 2/29/2008
Authors: Louis P Hromada, Brian Joseph Nablo, Michael Gaitan, John J Kasianowicz, Don DeVoe
Abstract: A polymer microfluidic platform for electrophysiological ion channel measurements is presented. The system includes an open-well bilayer lipid membrane formation site, integrated Ag/AgCl reference electrodes for on-chip electrical measurements, and m ...

23. The Detection and Characterization of Ions, DNA and Proteins with Nanometer-Scale Pores
Published: 12/1/2007
Authors: John J Kasianowicz, Jeffrey C. Lerman, Sarah E Henrickson, Martin Misakian, Rekha Panchal, Kelly Halverson, Sina Bavari, Tam Nguyen, Rick Gussio, Devanand K. Shenoy, Vincent M Stanford
Abstract: Protein ion channels are nanometer-scale pores that are central to many biological processes, including the sensing of a wide variety of molecules. They have also demonstrated their potential for use in the sensitive and selective detection of ions, ...

24. Liposome Characterization with Fluorescence Cumulant Analysis
Published: 6/8/2007
Authors: Joseph E. Reiner, Andreas Jahn, Laurie E Locascio, Michael Gaitan, John J Kasianowicz
Abstract: Liposomes are self-assembled spherical vesicles comprised of a lipid bilayer membrane that segregates an internal aqueous environment from an external aqueous environment. These nanometer-scale structures have demonstrated potential for targeted drug ...

25. Numerical Fluorescence Correlation Spectroscopy for Molecular Dynamics Analyses Under Non-Standard Conditions
Published: 6/1/2007
Authors: Michael J Culbertson, Joshua T Williams, Wayland Cheng, Dee A Stults, Emily R Wiebrach, John J Kasianowicz, Daniel L Burden
Abstract: A major concern in Fluorescence Correlation Spectroscopy (FCS) pertains to the accuracy of standard mathematical models that are used to extract kinetic information from correlated data. The standard equations used in FCS arise from a simple Gaussian ...

26. Single Molecule Mass Spectrometry in Solution Using a Solitary Nanopore
Published: 5/15/2007
Authors: Joseph William Robertson, Claudio G Rodrigues, Oleg V Krasilnikov, Vincent M Stanford, Kenneth Alan Rubinson, John J Kasianowicz
Abstract: A solitary protein nanometer-scale pore provides the basis for single molecule mass spectrometry in solution. Individual poly(ethylene glycol) molecules of different mass that enter a nanopore cause distinct and statistically resolved conductance sta ...

27. Molecular-scale structural and functional characterization of sparsely tethered bilayer lipid membranes
Published: 3/1/2007
Authors: Duncan J. McGillivray, Gintaras Valincius, David J. Vanderah, W. Febo-Ayala, John Taylor Woodward IV, Frank Heinrich, John J Kasianowicz, Mathias Losche

28. Enhancing molecular flux through nanopores via attractive interactions
Published: 11/1/2006
Authors: John J Kasianowicz, Tam Nguyen, Vincent M Stanford
Abstract: The classic experiments by Galvani and his colleagues in the 1790s led him to suggest that neural conduction and muscle contraction are governed by a form of animal electricity. Nearly 100 years later, Santiago Ramon y Cajal?s use of Golgi stains pro ...

29. Enhancing Molecular Flux Through Nanopores Via Attractive Interactions
Published: 8/1/2006
Authors: John J Kasianowicz, T L Nguyen, Vincent M Stanford

30. Enzyme Activity to Augment the Characterization of Tethered Bilayer Membranes
Published: 6/1/2006
Authors: Gintaras Valincius, Duncan J. McGillivray, W. Febo-Ayala, David J. Vanderah, John J Kasianowicz, Mathias Losche
Abstract: The structural order of tethered lipid bilayers (tBLMs) on solid substrates, investigated with electrochemical impedance spectroscopy (EIS) and neutron reflectivity (NR), is further characterized by phospholipase activity. Whereas EIS and NR data in ...

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