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Author: john kasianowicz
Displaying records 21 to 30 of 62 records.
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21. The Detection and Characterization of Ions, DNA and Proteins with Nanometer-Scale Pores
John J Kasianowicz, Jeffrey C. Lerman, Sarah E Henrickson, Martin Misakian, Rekha Panchal, Kelly Halverson, Sina Bavari, Tam Nguyen, Rick Gussio, Devanand K. Shenoy, Vincent M Stanford
Protein ion channels are nanometer-scale pores that are central to many biological processes, including the sensing of a wide variety of molecules. They have also demonstrated their potential for use in the sensitive and selective detection of ions, ...
22. Liposome Characterization with Fluorescence Cumulant Analysis
Joseph Earl Reiner, Andreas Jahn, Laurie E Locascio, Michael Gaitan, John J Kasianowicz
Liposomes are self-assembled spherical vesicles comprised of a lipid bilayer membrane that segregates an internal aqueous environment from an external aqueous environment. These nanometer-scale structures have demonstrated potential for targeted drug ...
23. Numerical Fluorescence Correlation Spectroscopy for Molecular Dynamics Analyses Under Non-Standard Conditions
Michael J Culbertson, Joshua T Williams, Wayland Cheng, Dee A Stults, Emily R Wiebrach, John J Kasianowicz, Daniel L Burden
A major concern in Fluorescence Correlation Spectroscopy (FCS) pertains to the accuracy of standard mathematical models that are used to extract kinetic information from correlated data. The standard equations used in FCS arise from a simple Gaussian ...
24. Single Molecule Mass Spectrometry in Solution Using a Solitary Nanopore
Joseph William Robertson, Claudio G Rodrigues, Oleg V Krasilnikov, Vincent M Stanford, Kenneth A. Rubinson, John J Kasianowicz
A solitary protein nanometer-scale pore provides the basis for single molecule mass spectrometry in solution. Individual poly(ethylene glycol) molecules of different mass that enter a nanopore cause distinct and statistically resolved conductance sta ...
25. Molecular-scale structural and functional characterization of sparsely tethered bilayer lipid membranes
Duncan J. McGillivray, Gintaras Valincius, David J. Vanderah, W. Febo-Ayala, John Taylor Woodward IV, Frank Heinrich, John J Kasianowicz, Mathias Losche
26. Enhancing molecular flux through nanopores via attractive interactions
John J Kasianowicz, Tam Nguyen, Vincent M Stanford
The classic experiments by Galvani and his colleagues in the 1790s led him to suggest that neural conduction and muscle contraction are governed by a form of animal electricity. Nearly 100 years later, Santiago Ramon y Cajal?s use of Golgi stains pro ...
27. Enhancing Molecular Flux Through Nanopores Via Attractive Interactions
John J Kasianowicz, T L Nguyen, Vincent M Stanford
28. Enzyme Activity to Augment the Characterization of Tethered Bilayer Membranes
Gintaras Valincius, Duncan J. McGillivray, W. Febo-Ayala, David J. Vanderah, John J Kasianowicz, Mathias Losche
The structural order of tethered lipid bilayers (tBLMs) on solid substrates, investigated with electrochemical impedance spectroscopy (EIS) and neutron reflectivity (NR), is further characterized by phospholipase activity. Whereas EIS and NR data in ...
29. Enzyme Activity to Augment the Characterization of Tethered Bilayer Membranes
G Valincius, D J. McGillivray, W Febo-Ayala, David J. Vanderah, John J Kasianowicz, M Losche
30. Conductance and Ion Selectivity of a Mesoscopic Protein Nanopore Probed with Cysteine Scanning Mutagenesis
P Merzlyak, Maria-Fatima P. Capistrano, Angela Valeva, John J Kasianowicz, Oleg V Krasilnikov